Overview
Next-generation sequencing technology is most extensively applied in cancer and rare disease studies. In basic cancer research, basic studies aiming to elucidate its molecular mechanisms and clinical application to pinpoint gene mutations to optimize treatment strategies have made enormous progress. In rare disease study areas, it has successfully been applied to pinpoint the causative mutation in Mendelian diseases. However, the diagnostic rate still stays as low as 30~40% of the patients, and further bioinformatics development is required to increase the rate. We are still searching for analysis methods to pick up disease-related genes in “oligogenic disease” efficiently.
Modern biology has transitioned into a new dimension. Classical biochemistry, molecular biology and cell biology can no longer be pursued without sophisticated instrumentation technologies. Huge amounts of heterogeneous omics data produced by machines, including DNA/RNA sequences, mass spectrometry readouts, image analysis and FACS sorting, have to be weaved together in conjunction with biological phenotypes.
Similarly, the linkage between large scale information and clinical phenotypes requires these advanced information-producing technologies and the ability to reason about data-phenotype relationships in the face of uncertainty, which is addressed in part by the field of Bioinformatics. The field is emerging to the center stage of biological and clinical research, and is continuing to develop new methodologies to handle the tsunami of information obtained and its required weaving.
The CCII organized the 1st International Symposium on Bioinformatics to invite many young scientists who are involved in or want to develop next generation biology using large scale data generation and its mathematical analysis.
Date & Time
January 15 (Fri), 2021
9:00-18:00 (JST)
Venue
Online (via Zoom)
Organizer
Tasuku Honjo, Director, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine
Fumihiko Matsuda, Director, Center for Genomic Medicine, Kyoto University Graduate School of Medicine
J.B. Brown, Adjunct Associate Professor, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine and Principal Scientist, Boehringer Ingelheim (Germany)
Program
Official Language: English
| Opening Lecture & Keynote Address Chairperson: Fumihiko Matsuda | ||
|---|---|---|
| 9:00-9:10 Opening Address | Tasuku Honjo (Director, Center for Cancer Immunotherapy and Immunobiology, Kyoto University, Japan) | |
| 9:10-9:50 Keynote Lecture | Cancer mutations in normal tissues Seishi Ogawa (Professor, Kyoto University Graduate School of Medicine, Japan) | |
| Session 1: Bioinformatics on Cancer Chairpersons: Marco A. Marra & Willy Hugo | ||
| 9:50-10:20 Lecture 1 | Towards a Canadian national program for comprehensive genomic profiling of treatment resistant cancers Marco A. Marra (Director, Canada’s Michael Smith Genome Sciences Centre, BC Cancer & Professor, Faculty of Medicine, University of British Columbia, Canada) | |
| 10:20-10:50 Lecture 2 | The intratumoral TCR dynamics under immunotherapy vs. targeted therapy Willy Hugo (Assistant Adjunct Professor, Department of Medicine, University of California Los Angeles, USA) | |
| 10:50-11:05 | Break | |
| 11:05-11:20 Short Talk 1 | Epigenome dysregulation resulting from NSD1 mutation in head and neck squamous cell carcinoma Bo Hu (Kyoto University, Japan & McGill University, Canada) | |
| 11:20-11:35 Short Talk 2 | Comparative analyses of cranial and extra-cranial rhabdoid tumours reveal subgroups with cytotoxic T cell infiltration Hye-Jung E. Chun (Canada’s Michael Smith Genome Sciences Centre, BC Cancer, Canada) | |
| 11:35-11:50 Short Talk 3 | Integrating DNA and RNA sequencing analysis to describe somatic alterations and expression in the HLA gene loci Katie M. Campbell (University of California Los Angeles, USA) | |
| 11:50-12:05 Short Talk 4 | Single cell RNAseq analyses reveal the cellular heterogeneity and molecular changes of AML/MDS Maiko Narahara (Daiichi Sankyo Co., Ltd., Japan) | |
| 12:05-13:00 | Lunch Break | |
| Session 2: Technical Development Chairpersons: Yasuhiro Murakawa & Joseph Ledsam | ||
| 13:00-13:30 Lecture 3 | A new genomic and computational approach to study human genomic enhancers and its association with diseases Yasuhiro Murakawa (Professor, Kyoto University Institute for Advanced Study, Japan) | |
| 13:30-14:00 Lecture 4 | Health and science at Google Joseph Ledsam (Clinician Scientist, Google Japan, Japan) | |
| 14:00-14:30 Lecture 5 | A machine learning approach to generate high-quality metabolite and lipid profiles from mass spectrometry data Shuji Kawaguchi (Associate Professor, Kyoto University Graduate School of Medicine, Japan) | |
| 14:30-14:45 Short Talk 5 | SingleCellHaystack: A clustering-independent method for finding differentially expressed genes in single-cell transcriptome data Alexis Vandenbon (Kyoto University, Japan) | |
| 14:45-15:00 Short Talk 6 | Development of a statistical variable selection method to identify useful biomarkers in metabolomic profiling Seri Kitada (Kyoto University, Japan) | |
| 15:00-16:00 | Break | |
| Session 3: Bioinformatics on Other Diseases Chairpersons: Matthew Hurles & J.B. Brown | ||
| 16:00-16:30 Lecture 6 | Deciphering the genetic architecture of developmental disorders Matthew Hurles (Head of Human Genetics, Wellcome Sanger Institute & Honorary Professor of Human Genetics and Genomics, University of Cambridge, UK) | |
| 16:30-17:00 Lecture 7 | Skills and thought processes that clinicians and experimentalists need to bridge into informatics J.B. Brown (Adjunct Associate Professor, Kyoto University Center for Cancer Immunotherapy and Immunobiology & Principal Scientist, Boehringer Ingelheim Germany) | |
| 17:00-17:15 Short Talk 7 | Transposable elements reveal inter-individual variability in the human response to influenza infection Xun Chen (Kyoto University, Japan) | |
| 17:15-17:30 Short Talk 8 | New strategies using unmapped reads to characterize viral sequences in different human populations Mio Shibata (Kyoto University, Japan & McGill University, Canada) | |
| 17:30-17:45 Short Talk 9 | A genetic landscape of pulmonary fibrosis in Japanese population -Preliminary results Tomoko Nakanishi (Kyoto University, Japan & McGill University, Canada) | |
| Closing Remarks | ||
| 17:45-17:50 | Fumihiko Matsuda | |
| . | ||