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CCII Seminar “Overcoming tumor immune resistance by manipulating tumor microenvironment”

Date, Time & Venue

Speaker

Dr. Daisuke Muraoka

Department of Oncology, Nagasaki University Graduate School of Biomedical Sciences

Abstract

Immune checkpoint inhibitors and gene-engineered T cell therapy are becoming very important for the treatment of advanced human cancers. However, it also has been revealed that a large part of cancer patients is still refractory to these immunotherapies. There can be multiple underlying mechanisms for tumor immune resistance. Especially the differences in tumor microenvironment (TME) has been considered key factors associated with tumor response to immune therapies. Therefore, various strategies to preferably manipulate TME have been tested in preclinical and clinical to improve the efficacy of existing immunotherapies. Here, we demonstrate that the antigen-loaded nanoparticle-mediated induction of antigen- presentation in tumor-associated macrophages or the small molecules- mediated activation of tumor-infiltrating T cells can improve the TME, leading to the reversal of tumor immune resistance.

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