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CCII Seminar “Ferroptosis in T cells: bridging systemic metabolism with immune function”, Prof. Di Yu

Date, Time & Venue

Speaker

Prof. Di Yu

Chair in Paediatric Immunotherapy, Professor of Imunology, Director of the Ian Frazer Centre of Children’s Immunotherapy Research
University of Queensland

Abstract

Ferroptosis is increasingly recognised as a critical non-apoptotic programmed cell death pathway, significantly impacting the homeostasis and functionality of peripheral CD8+ and CD4+ T cells. Our recent studies have revealed that TFH cells, which are crucial in regulating the dynamics of humoral immunity and vaccine response, demonstrate elevated lipid peroxidation and are particularly susceptible to ferroptosis. The enzyme glutathione peroxidase 4 (GPX4), a key scavenger of lipid peroxidation, is essential for TFH cell survival. Moreover, we have pinpointed several metabolic pathways that enhance T cell resistance to ferroptosis, thus modulating both humoral and cellular immunity across animal models and human subjects. These insights underscore the unique influence of ferroptosis in controlling T cell homeostasis and present a promising therapeutic avenue to boost T cell efficacy in vaccination and anti-tumour immunity.

Prof. Di Yu Seminarのサムネイル
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