CCII Seminar on “Suppression of epithelial proliferation and tumourigenesis by immunoglobulin A”｜Events｜Center for Cancer Immunotherapy and Immunobiology

Date, Time & Venue

28th November 2024, 11:00-12:00
Venue: CCII Bristol Myers Squibb Building (Bldg. No 2), Meeting Room (2F)
On-site participation, admission free
Organizer: Centre for Cancer Immunotherapy and Immunobiology (CCII)

Speaker

Prof. Daniel Mucida

Professor, The Rockefeller University Investigator, The Howard Hughes Medical Institute
RIKEN

Abstract

Immunoglobulin A (IgA) is the most abundant antibody isotype produced across mammals and plays a specialized role in mucosal homeostasis. Constantly secreted into the lumen of the intestine, IgA binds commensal microbiota to regulate their colonization and function with unclear implications for health. IgA deficiency is common in humans but is difficult to study due to its complex aetiology and comorbidities. Using genetically and environmentally controlled mice, here we show that IgA-deficient animals have increased susceptibility to endogenous colorectal tumours. The seminar will show cellular and molecular mechanisms related to these effects. Our observations establish a homeostatic function for IgA in tempering physiological epithelial responses to microbiota to maintain mucosal health.