Center for Cancer Immunotherapy and Immunobiology

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  5. Associate Prof. Maki Kobayashi

Associate Professor Maki Kobayashi
Department of Immunology and Genomic Medicine

　

Education

  • 1991: Graduated from the School of Medicine, Tsukuba University (M.D.)
  • 2001: Graduated from the Graduate School of Medicine, Tsukuba University (Ph.D.) (research supervisor: Prof. Masayuki Yamamoto, Department of Molecular and Developmental Biology, TARA Center; currently Prof. of Biochemistry and Molecular Biology, Tohoku Medical Megabank, Tohoku University)

Professional Experience

  • 1991-1992: Pediatric Department of Tsukuba University Hospital
  • 1992-1993: Ibaraki Children’s Hospital
  • 1994-1997: Pediatric Department of Tsukuba University Hospital
  • 2001-2004: JSPS-PD
  • 2005-2007: JST-ERATO Yamamoto Environmental Response Project
  • 2008~: Department of Immunology and Genomic Medicine, Kyoto University

Research Focus

Selected Publications

Maki Kobayashi, Hiroyuki Wakaguri, Masakazu Shimizu, Koichiro Higasa, Fumihiko Matsuda,  Tasuku Honjo. Ago2 and a miRNA reduce Topoisomerase 1 for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase. PNAS USA120: e2216918120 (2023). DOI: https://doi.org/10.1073/pnas.2216918120

Wajid Amin, Shoki Nishio, Tasuku Honjo, Maki Kobayashi. Necessity of HuR/ELAVL1 for activation-induced cytidine deaminase-dependent decrease in topoisomerase 1 in antibody diversification. International Immunology, dxad011 (2023). DOI: https://doi.org/10.1093/intimm/dxad011

Ziwei Yin, Maki Kobayashi, Wenjun Hu, Koichi Higashi, Nasim A. Begum, Ken Kurokawa, Tasuku Honjo. RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase, Proceedings of the National Academy of Sciences, 117(21) 11624-11635, May 26, 2020. DOI: https://doi.org/10.1073/pnas.1921115117

Helena Islam, Maki Kobayashi, Tasuku Honjo. Apurinic/apyrimidinic endonuclease 1 (APE1) is dispensable for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation in the immunoglobulin gene, International Immunology, 31(8) 543-554, Jul 30, 2019. DOI: https://doi.org/10.1093/intimm/dxz028 

Afzal Husain, Nasim A. Begum, Takako Taniguchi, Hisaaki Taniguchi, Maki Kobayashi, Tasuku Honjo. Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability, Nature Communications, 7(1), Apr, 2016. DOI: https://doi.org/10.1038/ncomms10549

Nasim A. Begum, Hithoshi Nagaoka, Maki Kobayashi and Tasuku Honjo. Molecular Mechanism of AID Function. Chapter 18 in Molecular Biology of B cells, Edited by F. Alt, T. Honjo, A. Radbruch and M. Reth. Academic Press, London, UK. 2015. DOI: https://doi.org/10.1016/b978-0-12-397933-9.00018-7

Jianliang Xu, Afzal Husain, Wenjun Hu, Tasuku Honjo and Maki Kobayashi. APE1 is dispensable for S region cleavage but required for its repair in class switch recombination. PNAS USA. 111:17242-7, 2014. DOI: https://doi.org/10.1073/pnas.1420221111

Somayeh Sabouri, Maki Kobayashi, Nasim A. Begum, Jianliang Xu, Kouji Hirota, Tasuku Honjo. C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion. PNAS USA. 111:2253-2258. 2014. DOI: https://doi.org/10.1073/pnas.132405711

Maki Kobayashi, Zahra Sabouri, Somayeh Sabouri, Yoko Kitawaki, Yves Pommier, Takaya Abe, Hiroshi Kiyonari and Tasuku Honjo. Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation. PNAS USA. 108:19305-19310 (2011). DOI: https://doi.org/10.1073/pnas.1114522108

Maki Kobayashi, Masatoshi Aida, Hitoshi Nagaoka, Nasim A. Begum, Yoko Kitawaki, Mikiyo Nakata, Andre Stanlie, Tomomitsu Doi, Lucia Kato, Il-mi Okazaki, Reiko Shinkura, Masamichi Muramatsu, Kazuo Kinoshita, and Tasuku Honjo. AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination. PNAS 106:22375-22380 (2009). DOI: https://doi.org/10.1073/pnas.0911879106

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