Center for Cancer Immunotherapy and Immunobiology

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  5. Associate Prof. Nasim A. Begum

Associate Professor Nasim Begum
Department of Immunology and Genomic Medicine

　

ORCID: https://orcid.org/0000-0001-7177-188X

Education

  • B.Sc.and M.Sc. in Life Science, Visva Bharati University, India  
  • PhD in Biochemistry, Indian Institute of Chemical Biology and Jadavpur University, Calcutta, India 
  • Postdoctoral Trainings: 1. University of Massachusetts Medical Center, USA (Cancer Biology, Prognostic Marker, and Gene Regulation, 2. Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan (Viral Receptor, Adjuvant Therapy, and Innate Immune Gene Regulation)

Professional Experience

  • Scientist, Department of Biophysics, Indian Institute of Chemical Biology, Calcutta, India
  • Assistant Professor, Department of Immunology and Genomic Medicine, Kyoto University
  • Associate Professor, Department of Immunology and Genomic Medicine, Kyoto University

Research Focus

Selected Publications

Refaat, A. M., Nakata, M., Husain, A., Kosako, H., Honjo, T., Begum, N.A.. HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression. Cell Rep, 42(3), 112284 (2023). DOI: 10.1016/j.celrep.2023.112284

Haque, F., Honjo, T., Begum, N.A.. XLID syndrome gene Med12 promotes Ig isotype switching through chromatin modification and enhancer RNA regulation. Sci Adv, 8(47), eadd1466 (2022). DOI: 10.1126/sciadv.add1466

Begum, N.A., Haque, F., Stanlie, A., Husain, A., Mondal, S., Nakata, M., Taniguchi, T., Taniguchi, H., Honjo, T.. Phf5a regulates DNA repair in class switch recombination via p400 and histone H2A variant deposition. EMBO J, 40(12), e106393 (2021). DOI: 10.15252/embj.2020106393

Husain, A., Xu, J., Fujii, H., Nakata, M., Kobayashi, M., Wang, J. Y., Rehwinkel, J., Honjo, T., Begum N.A. SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination. EMBO J, 39(15), e102931 (2020). DOI: 10.15252/embj.2019102931

Mondal, S., Begum N.A., Hu, W., & Honjo, T. Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins. Proc Natl Acad Sci U S A, 113(11), E1545-1554 (2016). DOI: 10.1073/pnas.1601678113

Husain, A., Begum N.A., Taniguchi, T., Taniguchi, H., Kobayashi, M., & Honjo, T.. Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability. Nat Commun, 7, 10549 (2016). DOI: 10.1038/ncomms10549

Hu, W., Begum N.A., Mondal, S., Stanlie, A., & Honjo, T. Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase. Proc Natl Acad Sci U S A, 112(18), 5791-5796 (2015). DOI: 10.1073/pnas.1506167112

Stanlie, A., Yousif, A. S., Akiyama, H., Honjo, T., Begum N.A. Chromatin reader Brd4 functions in Ig class switching as a repair complex adaptor of nonhomologous end-joining. Mol Cell, 55(1), 97-110 (2014). DOI: 10.1016/j.molcel.2014.05.018

Stanlie, A., Aida, M., Muramatsu, M., Honjo, T., Begum N.A. Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination. Proc Natl Acad Sci U S A, 107(51), 22190-22195 (2010). DOI: 10.1073/pnas.1016923108

Begum N.A., Kinoshita, K., Kakazu, N., Muramatsu, M., Nagaoka, H., Shinkura, R. Honjo, T. Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch. Science, 305(5687), 1160-1163 (2004). DOI: 10.1126/science.1098444; https://www.nature.com/articles/nri1465; https://www.science.org/doi/abs/10.1126/science.1102692

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