Center for Cancer Immunotherapy and Immunobiology

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  5. Associate Professor Seo Wooseok

Associate Professor Seo Wooseok
Division of Cancer Immune Multicellular System Regulation

Education

  • 2002: University of Calgary, MSc
  • 2008: University of British Columbia, PhD in Medicine

Professional Experiences

  • 2008-2009: University of British Columbia, Biomedical Research Centre, Researcher
  • 2009-2019: RIKEN, Center for Integrative Medical Sciences, Researcher
  • 2019-2024: Nagoya University Graduate School of Medicine, Department of Immunology, Designated Associate Professor
  • 2023-2024: Nagoya University Graduate School of Medicine, Institute for Advanced Study, Young Researcher Unit, Unit leader
  • 2025-Current: Kyoto University Graduate School of Medicine, Center for Cancer Immunotherapy and Immunobiology, Division of Cancer Immune Multicellular System Regulation, Associate Professor

Research Focus

Memberships

Selected Publications

Original Articles

1. Hung CJ, Tsai C-T, Rahaman SM, Yamanaka A, Seo W, Yokoyama T, Sakamoto M, Ono D. Neuropeptidergic input from the lateral hypothalamus to the suprachiasmatic nucleus alters the circadian period in mice. The Journal of Neuroscience, 2024. e0351242024-e0351242024.

2. Nomura A, Kobayashi T, Seo W, Ohno-Oishi M, Kakugawa K, Muroi S, Yoshida H, Endo, T A. Moro K, Taniuchi, I. Identification of a novel enhancer essential for Satb1expression in TH2 cells and activated ILC2s. Life Science Alliance. 2023. DOI: 10.26508/lsa.202301897.

3. Seo W, Shimizu K, Kojo S, Okeke A, Kohwi-Shigematsu T, Fujii S-I, Taniuchi I. Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity. Nat. Commun., 2020, 11 (1), 1562.

4. Kojo S, Ohno-Oishi M, Wada H, Nieke S, Seo W, Muroi S, Taniuchi I. Constitutive CD8 expression drives innate CD8+ T-cell differentiation via induction of iNKT2 cells. LSA, 2020, 3 (2).

5. Tenno M, Wong A, Ikegaya M, Miyauchi E, Seo W, See P, Kato T, Taida T, Oishi-Ohno M, Ohno H, Yoshida H, Ginhoux F, Taniuchi I. Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt+ T cells. LSA, 2019, 3 (1).

6. Kojo S, Tanaka H, Endo TA, Muroi S, Liu Y, Seo W, Tenno M, Kakugawa K, Naoe Y, Nair K, Moro K, Katsuragi Y, Kanai A, Inaba T, Egawa T, Venkatesh B, Minoda A, Kominami R, Taniuchi I. Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes. Nat. Commun., 2017, 8 (1), 702.

7. Kakugawa K, Kojo S, Tanaka H, Seo W, Endo T, Katagawa Y, Muroi S, Tenno M, Yasmine N, Kohwi Y, Sakaguchi S, Kowhi-Shigematsu T, Taniuchi I. Essential Roles of SATB1 in Specifying T Lymphocyte Subsets. Cell Reports, 2017, 19 (6), 1176-1188.

8. Seo W, Muroi S, Akiyama K, Taniuchi I. Distinct requirement of Runx complexes for TCRβ enhancer activation at distinct developmental stages. Sci. Rep., 2017, 7, 41351.

9. Tanaka H, Naito T, Muroi S, Seo W, Chihara R, Miyamoto C, Kominami R, Taniuchi I. Epigenetic Thpok silencing limits the time window to choose CD4+ helper-lineage fate in the thymus. EMBO J., 2013, 32 (8), 1183-1194.

10. Seo W, Ikawa T, Kawamoto H. and Taniuchi I. Runx1-Cbfβ facilitates early B lymphocyte development by regulating expression of Ebf1. J. Exp. Med., 2012, 209 (7), 1255-1262.

Review Articles

1. Seo W, Nomura A, Taniuchi I. The Roles of RUNX Proteins in Lymphocyte Function and Anti-Tumor Immunity. Cells, 2022, 11 (19), 3116.

2. Seo W, Jerin C, Nishikawa H. Transcriptional regulatory network for the establishment of CD8 + T cell exhaustion. Exp. Mol. Med., 2021, 53 (2), 202-209.

3. Seo W & Taniuchi I. The Roles of RUNX Family Proteins in Development of Immune Cells. Mol. Cells, 2020, 43 (2), 107-113.

4. Seo W & Taniuchi I. Too much can be as bad as too little. Nat. Immunol., 2019, 20, 1262-1264.

5. Seo W & Taniuchi I. Regulation of hematopoiesis and immune responses by long noncoding RNAs. Int. Immunol., 2017, 29 (4), 165-172.

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