Education

• 2017-2022 Ph.D. Graduate School of Medicine. Kyoto University
• 2006-2012 M.D. School of Medicine, Hiroshima University

Professional Experiences

• 2012-2013 Junior resident, Department of Pediatrics, Kitano Hospital, Osaka, Japan
• 2014-2016 Senior resident, Department of Pediatrics, Kitano Hospital, Osaka, Japan
• 2017 Department of Pediatrics, Kyoto University Hospital, Kyoto, Japan
• 2021-2024 Research fellow, Department of Pediatrics, Graduate School of Medicine, Kyoto University
• 2024 Research fellow, Department of Immunology, Graduate School of Medicine, Nagoya University
• 2025-Current Program-specific Assistant Professor, Division of Cancer Immune Multicellular System Regulation, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine

Research Focus

After graduating from Hiroshima University in 2012, I started to build my career as a pediatrician at Kitano Hospital in Osaka. In the five years as a resident, I have gained a wide range of experience in the field and decided to specialize in childhood cancer. Subsequently, I got transferred to Kyoto University Hospital and learned how to treat patients with severe cancers. My academic pursuit continued at Department of Pediatrics, Kyoto University Graduate School of Medicine, where I uncovered an immune environment of B-cell precursor acute lymphoblastic leukemia in children. Following my Ph.D., I have been researching cancer immunity related to leukemia and other pediatric cancers, especially regarding CD19-targeted immunotherapies.

Memberships

• Board certified member and Senior fellow of the Japan Pediatric Society
• Board certified member and Senior fellow of the Japanese Society of Hematology
• Member of the Japanese Cancer Association
• Member of the Japanese Society of Pediatric Hematology / Oncology

Selected Publications

• Kuniaki Tanaka, Itaru Kato, Yuu Dobashi, Jun-ichi Imai, Takashi Mikami, Hirohito Kubota, Hiroo Ueno, Mamoru Ito, Seishi Ogawa, Tatsutoshi Nakahata, Junko Takita, Hidemi Toyoda, Chitose Ogawa, Souichi Adachi, Shinya Watanabe, Hiroaki Goto. The first domestic Japanese biobank of patient-derived pediatric acute lymphoblastic leukemia xenograft models. Cancer Sci. 2022; 113(11): 3814-3825. doi: 10.1111/cas.15506.
• Naoko Kawabata, Hidefumi Hiramatsu, Takashi Mikami, Ryo Akazawa, Kuniaki Tanaka, Kagehiro Kouzuki, Hirohito Kubota, Satoshi Saida, Itaru Kato, Katsutsugu Umeda, Tomoaki Hirate, Kaori, Kanda, Souichi Adachi, Junko Takita. Chimeric antigen receptor T-cell therapy for a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia and leukoencephalopathy who relapsed after bone marrow transplantation. Pediatr Blood Cancer. 2022; 69(11): e29734. doi: 10.1002/pbc.29734.
• Takashi Mikami, Itaru Kato, James Badger Wing, Hiroo Ueno, Keiji Tasaka, Kuniaki Tanaka, Hirohito Kubota, Satoshi Saida, Katsutsugu Umeda, Hidefumi Hiramatsu, Tomoya Isobe, Mitsuteru Hiwatari, Ai Okada, Kenichi Chiba, Yuichi Shiraishi, Hiroko Tanaka, Satoru Miyano, Yuki Arakawa, Koichi Oshima, Katsuyoshi Koh, Souichi Adachi, Keiko Iwaisako, Seishi Ogawa, Shimon Sakaguchi, Junko Takita. Alteration of the immune environment in bone marrow from children with recurrent B cell precursor acute lymphoblastic leukemia. Cancer Sci. 2022; 113(1): 41-52. doi: 10.1111/cas.15186.
• Takashi Mikami, Itaru Kato, Nanami Oiki, Seiji Okamoto, Tatsuya Kamitori, Keiji Tasaka, Hideto Ogata, Kuniaki Tanaka, Katsutsugu Umeda, Hidefumi Hiramatsu, Takeshi Okamoto, Souichi Adachi, Junko Takita. Improvement of bone marrow necrosis by tyrosine kinase inhibitor substitution in a pediatric patient with Philadelphia chromosome-positive acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2022; 44(2): e539-e542. doi: 10.1097/MPH.0000000000002157.
• Takashi Mikami, Hiroshi Mizumoto, Toshiro Katayama, Daisuke Hata. Transition of gastric pH after birth for verification of feeding tube placement. Pediatr Int. 2019; 61(8): 832-834. doi: 10.1111/ped.13918.
• Takashi Mikami, Itaru Kato, Katsutsugu Umeda, Tatsuya Kamitori, Keiji Tasaka, Hideto Ogata, Hidefumi Hiramatsu, Souichi Adachi. Sudden spinal hemorrhage in a pediatric case with total body irradiation-induced cavernous hemangioma. Pediatr Blood Cancer. 2018; 65(10): e27250. doi: 10.1002/pbc.27250.