Center for Cancer Immunotherapy and Immunobiology

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Multi-Omics Platform
Together with our collaborators at Kyoto University and in industry, we have been building a powerful new multi-omics platform to accelerate research into interactions between cancer and the immune system. This platform is available to all scientists at CCII and Kyoto University.

Research Focus

Harnessing Immuno-metabolomics for the Identification of Biomarkers and the Accurate Assessment of Immune System States

The immune system is preferentially nutrient-demanding, enabling it to respond promptly to infections and cancers. This demand triggers the metabolic remodeling of specific subsets of immune cells from the earliest stages of activation, which leads to a detectable footprint of metabolites in the blood. Consequently, monitoring these metabolites provides a powerful means to accurately evaluate the state of the immune system, potentially predicting the severity of infections, the likelihood of developing autoimmune diseases, and the efficacy of cancer immunotherapies. However, the correlation between the state of the immune system, specifically the activation of particular immune cell subsets, and the resulting serum metabolite profile remains unclear.

At the CCII, we aim to employ advanced mass spectrometry techniques to extensively investigate metabolite markers linked with specific immune cell activations. The primary goals are to develop:

Furthermore, utilizing a variety of disease models and immunodeficient mice, we intend to pinpoint the metabolic pathways required for the activation and functionality of specific immune cells. Through the identification of these metabolic pathways, we plan to devise interventional therapies that enhance immune cell function by replenishing metabolites necessary for desirable immune responses, such as those involved in cancer immunity. Inversely, by identifying metabolic pathways that inhibit specific immune cells, we could unveil potential targets for metabolic interventions to suppress hypersensitivity reactions, autoimmune diseases, and the cytokine storms often observed in severe infectious diseases.

We aim at advancing the above research in the context of both clinical and basic research. 

Members

Professors

Associate Prof.
Yuki Sugiura
Assistant Prof.
Yuta Matsuoka

Recent Publications (Selection）

Sone, M., Mitsuhashi, N., Sugiura, Y. et al. Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator. Cell Death Dis 15, 685 (2024). DOI: https://doi.org/10.1038/s41419-024-07059-w

Shintaro Watanuki, Hiroshi Kobayashi, Yuki Sugiura, Masamichi Yamamoto, Daiki Karigane, Kohei Shiroshita, Yuriko Sorimachi, Takayuki Morikawa, Shinya Fujita, Kotaro Shide, Miho Haraguchi, Shinpei Tamaki, Takumi Mikawa, Hiroshi Kondoh, Hiroyasu Nakano, Kenta Sumiyama, Go Nagamatsu, Nobuhito Goda, Shinichiri Okamoto, Ayako Nakamura-Ishizu, Kazuya Shimoda, Makoto Suematsu, Toshio Suda, Keiyo Takubo, SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production. Cell Stem Cell, Volume 31, Issue 8, 2024, Pages 1145-1161.e15, DOI: https://doi.org/10.1016/j.stem.2024.04.023.

Yamashita, Si., Sugiura, Y., Matsuoka, Y. et al. Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species.Cell Death Differ 31, 651–661 (2024). DOI: https://doi.org/10.1038/s41418-024-01280-y

Maeda, R., Seki, N., Uwamino, Y. et al. Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19. Nat Commun 14, 8469 (2023). DOI: https://doi.org/10.1038/s41467-023-44266-z

Nomura, M., Ohuchi, M., Sakamoto, Y. et al. Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma. Nat Commun 14, 8095 (2023). DOI: https://doi.org/10.1038/s41467-023-43630-3

Kazuya Nishio, Tomoyuki Kawarasaki, Yuki Sugiura, Shunsuke Matsumoto, Ayano Konoshima, Yuki Takano, Mayuko Hayashi, Fumihiko Okumura, Takumi Kamura, Tsunehiro Mizushima, Kunio Nakatsukasa. Defective import of mitochondrial metabolic elicits ectopic metabolic stress. Science advances, 9(15) eadf1956, Apr 14, 2023. DOI: https://doi.org/10.1126/sciadv.adf1956  

Hirona Kugo, Yuki Sugiura, Rena Fujishima, Shintou Jo, Hirotaka Mishima, Erina Sugamoto, Hiroki Tanaka, Satoshi Yamaguchi, Yoshihiko Ikeda, Ken-Ichi Hirano, Tatsuya Moriyama, Nobuhiro Zaima. Tricaprin can prevent the development of AAA by attenuating aortic degeneration. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 160 114299-114299, Apr, 2023. DOI: https://doi.org/10.1016/j.biopha.2023.114299  

Nourin Jahan, Hiroyuki Ohsaki, Kiyoko Kaneko, Asadur Rahman, Takeshi Nishiyama, Makoto Koizumi, Shuichiro Yamanaka, Kento Kitada, Yuki Sugiura, Kenji Matsui, Takashi Yokoo, Takayuki Hamano, Makoto Kuro-O, Takuya Itou, Miwa Suzuki, Keiichi Ueda, Akira Nishiyama. Possible contribution of phosphate to the pathogenesis of chronic kidney disease in dolphins. Scientific reports, 13(1) 5161-5161, Mar 29, 2023. DOI: https://doi.org/10.1038/s41598-023-32399-6  

Yu Nakagama, Katherine Candray, Natsuko Kaku, Yuko Komase, Maria-Virginia Rodriguez-Funes, Rhina Dominguez, Tomoya Tsuchida, Hiroyuki Kunishima, Etsuko Nagai, Eisuke Adachi, Dieudonné Mumba Ngoyi, Mari Yamasue, Kosaku Komiya, Kazufumi Hiramatsu, Naoto Uemura, Yuki Sugiura, Mayo Yasugi, Yuka Yamagishi, Hiroshige Mikamo, Satoshi Shiraishi, Takehiro Izumo, Sachie Nakagama, Chihiro Watanabe, Yuko Nitahara, Evariste Tshibangu-Kabamba, Hiroshi Kakeya, Yasutoshi Kido. Antibody Avidity Maturation Following Recovery From Infection or the Booster Vaccination Grants Breadth of SARS-CoV-2 Neutralizing Capacity. The Journal of infectious diseases, 227(6) 780-787, Mar 28, 2023. DOI: https://doi.org/10.1093/infdis/jiac492  

Shintaro Watanuki, Hiroshi Kobayashi, Yuki Sugiura, Masamichi Yamamoto, Daiki Karigane, Kohei Shiroshita, Yuriko Sorimachi, Shuhei Koide, Motohiko Oshima, Akira Nishiyama, Koichi Murakami, Miho Haraguchi, Shinpei Tamaki, Takehiro Yamamoto, Tomohiro Yabushita, Yosuke Tanaka, Hiroaki Honda, Shinichiro Okamoto, Nobuhito Goda, Tomohiko Tamura, Ayako Nakamura-Ishizu, Makoto Suematsu, Atsushi Iwama, Toshio Suda, Keiyo Takubo. Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis. bioRxiv, Mar 16, 2023. DOI: https://doi.org/10.1101/2023.03.16.532898 

Xiaoxiao Liu, Naru Sato, Tomohiro Yabushita, Jingmei Li, Yuhan Jia, Moe Tamura, Shuhei Asada, Takeshi Fujino, Tsuyoshi Fukushima, Taishi Yonezawa, Yosuke Tanaka, Tomofusa Fukuyama, Akiho Tsuchiya, Shiori Shikata, Hiroyuki Iwamura, Chieko Kinouchi, Kensuke Komatsu, Satoshi Yamasaki, Tatsuhiro Shibata, Atsuo T Sasaki, Janet Schibler, Mark Wunderlich, Eric O’Brien, Benjamin Mizukawa, James C Mulloy, Yuki Sugiura, Hitoshi Takizawa, Takuma Shibata, Kensuke Miyake, Toshio Kitamura, Susumu Goyama. IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia. EMBO molecular medicine, 15(1) e15631, Jan 11, 2023. DOI: https://doi.org/10.15252/emmm.202115631  

Kenji Morino, Kazufumi Kunimura, Yuki Sugiura, Yoshihiro Izumi, Keisuke Matsubara, Sayaka Akiyoshi, Rae Maeda, Kenichiro Hirotani, Daiji Sakata, Seiya Mizuno, Satoru Takahashi, Takeshi Bamba, Takehito Uruno, Yoshinori Fukui. Cholesterol sulfate limits neutrophil recruitment and gut inflammation during mucosal injury. Frontiers in immunology, 14 1131146-1131146, 2023. DOI: https://doi.org/10.3389/fimmu.2023.1131146  

Recruitment & Contact

We are permanently recruiting highly motivated students, postdoctoral fellows, and technical staff regardless of previous scientific backgrounds.

Please contact us using CCII’s contact form or by directly sending an email to recruit_ccii@mail2.adm.kyoto-u.ac.jp. Please indicate in which position and subject area you are interested in and that your inquiry is about our platform.

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