Center for Cancer Immunotherapy and Immunobiology

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Associate Professor Kazuhiro Sonomura
Visiting Associate Professor

　

Education

  • 2004: Faculty of Pharmaceutical Science, Kyoto University
  • 2006: Graduate School of Pharmaceutical Science, Kyoto University
  • 2011: Doctor of Pharmaceutical Science, Kyoto University

Professional Experience

  • 2006~: Shimadzu Corporation
  • 2007-2011: Collaborative researcher, Institute for Protein Research, Osaka University
  • 2014~: Collaborative researcher, Graduate School of Medicine, Kyoto University
  • 2022~: Visiting Associate Professor, Center for Cancer Immunotherapy and Immunobiology (CCII)

Research Focus

In recent years, metabolome analysis using mass spectrometry has been widely used for elucidating disease mechanisms and searching for biomarkers. In addition, metabolome information, which is an intermediate trait between genome and phenotype, is an important piece for clarifying immune and other biological systems, and the development of metabolomics technology is indispensable for the advancement of life science. We have been developing novel metabolomics methodologies using mass spectrometry to search for disease-specific metabolite markers through the collaboration with Kyoto University. Our mission is to apply the established metabolomics platform for various biological samples to contribute to research at the Center for Cancer Immunotherapy and Immunobiology (CCII).

Selected Publications

Iwasaki T, Kamatani Y, Sonomura K, Kawaguchi S, Kawaguchi T, Takahashi M, Ohmura K, Sato TA, Matsuda F. Genetic influences on human blood metabolites in the Japanese population. iScience. 2022 Dec 6;26(1):105738. DOI: 10.1016/j.isci.2022.105738.

Al-Habsi, M., Chamoto, K., Matsumoto, K., Nomura, N., Zhang, B., Sugiura, Y., Sonomura, K., Maharani, A., Nakajima, Y., Wu, Y., Nomura, Y., Menzies, R., Tajima, M., Kitaoka, K., Haku, Y, Delghandi, S., Yurimoto, K., Matsuda, F., Iwata, S., Ogura, T., Fagarasan, S., and Honjo, T.. Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice. Science, 378(6618), eabj3510 (2022). DOI: 10.1126/science.abj3510

Tanaka, K., Chamoto, K., Saeki, S., Hatae, R., Ikematsu, Y., Sakai, K., Ando, N., Sonomura, K., Kojima, S., Taketsuna, M., Kim, Y. H., Yoshida, H., Ozasa, H., Sakamori, Y., Hirano, T., Matsuda, F., Hirai, T., Nishio, K., Sakagami, T., Fukushima, M., Nakanishi, Y., Honjo, T., and Okamoto, I.. Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer. Science Translational Medicine, 14(675), eabq0021 (2022). DOI: 10.1126/scitranslmed.abq0021

Brial, F., Alzaid, F., Sonomura, K., Kamatani, Y., Meneyrol, K., Le Lay, A., Péan, N., Hedjazi, L., Sato, T. A., Venteclef, N., Magnan, C., Lathrop, M., Dumas, M. E., Matsuda, F., Zalloua, P. and Gauguier, D. The natural metabolite 4-cresol improves glucose homeostasis and enhances β-cell function. Cell Rep. 30, 2306-2320.e5 (2020). DOI: 10.1016/j.celrep.2020.01.066

Hatae, R., Chamoto, K., Kim, Y. H., Sonomura, K., Taneishi, K., Kawaguchi, S., Yoshida, H., Ozasa, H., Sakamori, Y., Akrami, M, Fagarasan, S., Masuda, I., Okuno, Y., Matsuda, F., Hirai, T., Honjo, T. Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy. JCI Insight. 5, e133501 (2020). DOI: 10.1172/jci.insight.133501

Miyajima, M., Zhang, B., Sugiura, Y., Sonomura, K., Guerrini. M.M., Tsutsui, Y., Maruya, M., Vogelzang, A., Chamoto, K., Honda, K., Hikida, T., Ito, S., Qin, H., Sanuki, R., Suzuki, K., Furukawa, T., Ishihama, Y., Matsuda, F., Suematsu, M., Honjo, T., Fagarasan, S.. Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior. Nat Immunol. Dec;18(12):1342-1352 (2017). DOI: https://doi.org/10.1038/ni.3867

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