概要
Genetic factors play a critical role in human diseases. However, even in monogenic disorders caused by a mutation in a single gene, the current methodology using next-generation sequencing technology can only genetically diagnose less than 50% of patients. Moreover, conventional approaches have revealed only a tiny fraction of the heritability in many polygenic diseases caused by genetic and environmental factors.
Under such situations, investigating the intermediary traits that bridges genes and phenotypes becomes vital for better understanding the underlying disease mechanism. Various biomolecules in the body, such as cell transcripts, proteins and metabolites in blood and tissues, are typical intermediate traits involving the disorders. The technology to measure such biomolecules with high sensitivity and reproducibility has significantly progressed in the past few years.
In this symposium, world-leading scientists in genomics and omics studies presented the latest topics ranging from the causal gene identification in monogenic diseases to the technical development of omics analysis and its application to human disease studies.
オーガナイザー
- Tasuku Honjo, Director, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine
- Fumihiko Matsuda, Director, Center for Genomic Medicine, Kyoto University Graduate School of Medicine
開催日時
March 4 (Sat), 2023
9:00-17:45 (JST)
会場
On-site: Shiran Kaikan Inamori Hall, Faculty of Medicine, Kyoto University
On-line: Zoom (ID & Password to enter the symposium will be sent to the registered participants)
プログラム
| Opening Address Chairperson: Fumihiko Matsuda (Center for Genomic Medicine, Kyoto University, Japan) | ||
|---|---|---|
| 9:00-9:10 Opening Address | Tasuku Honjo (Director, Center for Cancer Immunotherapy and Immunobiology (CCII), Kyoto University, Japan) | |
| Session 1: Technological Development of Omics Analysis Chairpersons: Kazuhiro Sonomura (Life Science Research Center, Shimadzu Corporation/ CCII) Yuki Sugiura (CCII) | ||
| 9:10-9:50 Lecture 1 | RNA splicing is a crucial layer of omics analysis: The stories of cancer neoantigens and COVID-19 precision medicine Kei Iida (Graduate School of Science and Engineering, Kindai University, Japan) | |
| 9:50-10:30 Lecture 2 | Proteome-based approach to human health and disease Sumio Ohtsuki (Faculty of Life Science, Kumamoto University, Japan) | |
| 10:30-10:50 | Break | |
| 10:50-11:30 Lecture 3 | Extracting latent representation from life science data for understanding drugs Tadahaya Mizuno (Graduate School of Pharmaceutical Sciences, the University of Tokyo, Japan) | |
| 11:30-12:15 Short Talks 1 | Short Talks of Young Investigators Rong Ma (Center for Cancer Immunotherapy and Immunobiology, Kyoto University, Japan/ McGill University, Canada) Ayana Tomioka (Graduate School of Pharmaceutical Sciences, Kyoto University, Japan) Akiko Oguchi (ASHBi, Kyoto University, Japan) | |
| 12:15-13:50 | Lunch Break | |
| Session 2: Applications to Human Health and Disease Chairpersons: Dominique Gauguier (Institut National de la Sante et la Recherche Medicale, France) Tomi Pastinen (Genomic Medicine Center, Children’s Mercy Kansas City, USA) | ||
| 13:50-14:30 Lecture 4 | Computational Genomics for Precision Medicine Yosuke Tanigawa (Computational Biology Lab, Massachusetts Institute of Technology, USA) | |
| 14:30-15:10 Lecture 5 | Genomics of rare and functional variation in childhood disease Tomi Pastinen (Genomic Medicine Center, Children’s Mercy Kansas City, USA) | |
| 15:10-15:55 Short Talks 2 | Short Talks of Young Investigators Ta-Yu Yang (Center for Genomic Medicine, Kyoto University, Japan) Takeshi Iwasaki (Center for Genomic Medicine, Kyoto University, Japan) Seri Kitada (Center for Genomic Medicine, Kyoto University, Japan) | |
| 15:55-16:20 | Break | |
| 16:20-17:00 Lecture 6 | Impact of gut microbial metabolites on human health and diseases Dominique Gauguier (Institut National de la Sante et la Recherche Medicale, France) | |
| 17:00-17:40 | Identification of strategies to overcome immunotherapy resistance in melanoma using multi-omic approaches Ian Watson (Department of Biochemistry, McGill University, Canada) | |
| Closing Remarks: Bioinformatics on Other Diseases Chairperson: Fumihiko Matsuda (Center for Genomic Medicine, Kyoto University, Japan) | ||
| 17:40-17:50 | Mark Lathrop (McGill Genome Center, McGill University, Canada) | |
| . | ||