1964-1970

1. Enzymic preparation of nicotinate adenine dinucleotide (deamido-NAD). Honjo, T., Ikeda, M., Andreoli, A. J., Nishizuka, Y. and Hayaishi, O. Biochim. Biophys. Acta. 89, 549-552 (1964) 

2. Studies on the metabolism of the benzene ring of tryptophan in mammalian tissues. II. Enzymic formation of a-aminomuconic acid from 3-hydroxyanthranilic acid. Ichiyama, A., Nakamura, S., Kawai, H., Honjo, T., Nishizuka, Y., Hayaishi, O. and Senoh, S. J. Biol. Chem. 240, 740-749 (1965) 

3. Stoichiometric utilization of adenosine 5′-triphosphate in nicotinate ribonucleotide synthesis from nicotinate and 5-phosphoribosyl -1- pyrophosphate. Honjo, T., Nakamura, S., Nishizuka, Y. and Hayaishi, O. Biochem. Biophys. Res. Commun. 25, 199-204 (1966) 

4. Studies on the polymer of adenosine diphosphate ribose. II. Characterization of the polymer. Reeder, R. H., Ueda, K., Honjo, T., Nishizuka, Y. and Hayaishi, O. J. Biol. Chem. 242, 3172-3179 (1967) 

5. Poly adenosine diphosphate ribose synthesis and nicotinamide adenine dinucleotide transglycosidases. Nishizuka, Y., Ueda, K., Nakazawa, K., Reeder, R. H., Honjo, T. and Hayaishi, O. J. of Vitaminology 14, 143-152 (1968) 

6. Poly adenosine diphosphate ribose synthesis associated with chromatin. Ueda, K., Reeder, R. H., Honjo, T., Nishizuka, Y., and Hayaishi, O. Biochem. Biophys. Res. Commun. 31, 379-385 (1968) 

7. Nicotinamide adenine dinucleotide glycohydrolases and poly adenosine diphosphate rebose synthesis in rat liver. Nakazawa, K., Ueda, K., Honjo, T., Yoshihara, K., Nishizuka, Y. and Hayaishi, O. Biochem. Biophys. Res. Commun. 32, 143-149 (1968) 

8. Enzymic adenosine diphosphate ribosylation of histone and poly adenosine diphosphate ribose synthesis in rat liver nuclei. Nishizuka, Y., Ueda, K., Honjo, T. and Hayaishi, O. J.Biol.Chem.243, 3765-3767 (1968) 

9. Diphthria toxini-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis. Honjo, T., Nishizuka, Y., Hayaishi, O. and Kato, I. J. Biol. Chem. 243, 3553-3555 (1968) 

10. Adenosine diphosphoribosylation of aminoacyl transferase II by diphtheriatoxin. Honjo, T., Nishizuka, Y. and Hayaishi, O. Cold Spring Harbor Symp. Quant. Biol. 34, 603-608 (1969) 

1971-1980

11. Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin. Honjo, T., Nishizuka, Y., Kato, I. and Hayaishi, O. J. Biol. Chem. 246, 4251-4260 (1971) 

12. Nicotinate phosphoribosyltransferase from bakers’ yeast. Honjo, T. Methods in Enzymology Vol.XVIII Vitamins and coenzymes, Academic Press, New York, 123-127 (1971) 

13. Enzymatic preparation of nicotinic acid adenine dinucleotide, nicotinic acid ribonucleotide, and nicotinic acid ribonucleoside. Honjo, T. and Nishizuka, Y. Methods in Enzymology Vol.XVIII Vitamins and coenzymes,Academic Press, New York and London. 132-137 (1971) 

14. Diphtheria toxin-catalyzed adenosine diphosphoribosylation of aminoacyl transferase II from rat liver. Honjo, T., Ueda, K., Tanabe, T. and Hayaishi, O. International Symposium on Metabolic Interconversion of Enzymes. Springer-Verlag, Berlin and New York. 193-211 (1972) 

15. Preferential transcription of Xenopus laevis ribosomal RNA in interspecies hybrids between Xenopus laevis and Xenopus mulleri. Honjo, T. and Reeder, R. H. J. Mol. Biol. 80, 217-228 (1973) 

16. Enzymatic ADP-ribosylation of proteins and regulation of cellular activity. Honjo, T. and Hayaishi, O. Current Topics in Cellular Regulation Vol.7, Academic Press, New York. 87-127 (1973) 

17. Transcription of chromatin by amphibian RNA polymerase: Aberrant synthesis of ribosomal and 5S RNA. Honjo, T. and Reeder, R. H. Poly ADP-ribose International Symposium, U.S.Government Printing Office, Washington, D.C. 277-284 (1974) 

18. Transcription of Xenopus chromatin by homologous RNA polymerase: Aberrant synthesis of ribosomal and 5S RNA. Honjo, T. and Reeder, R. H. Biochemistry 13, 1896-1899 (1974) 

19. Organization of immunoglobulin genes: Reiteration frequency of the mouse k chain constant region gene. Honjo, T., Packman, S., Swan, D., Nau, M. and Leder, P. Proc.Natl. Acad. Sci. USA 71, 3659-3663 (1974) 

20. The organization of immunoglobulin genes. Leder, P., Honjo, T., Packman, S., Swan, D., Nau, M. and Norman, B. The Immune System; Genes, Receptors, Signals, (ed. by E.E. Sercarz, A.R. Williamson and C.F. Fox) Academic Press, New York. 299-317 (1974) 

21. The organization and diversity of immunoglobulin genes. Leder, P., Honjo, T., Packman, S., Swan, D., Nau, M. and Norman, B. Proc. Natl. Acad. Sci. USA 71, 5109-5114 (1974) 

22. Characterization of light chain and light chain constant region fragment mRNAs in MPC 11 mouse myeloma cells and variants. Kuehl, W. M., Kaplan, B. A., Scharff, M. D., Nau, M., Honjo, T. and Leder, P. Cell 5, 139-147 (1975) 

23. Purification and translation of an immunoglobulin l chain messenger RNA from mouse myeloma. Honjo, T., Swan, D., Nau, M., Norman, B., Packman, S., Polsky, F. and Leder, P. Biochemistry 15, 2775-2779 (1976) 

24. Quantitation of constant and variable region genes for mouse immunoglobulin l chains. Honjo, T., Packman, S., Swan, D. and Leder, P. Biochemistry 15, 2780-2785 (1976) 

25. The organization and diversity of immunoglobulin k and l genes. Leder, P., Honjo, T., Swan, D., Packman, S., Nau, M. and Norman, B. Molecular Approaches to Immunology (ed. by E.E. smith, D.W.Ribbons) Academic Press, New York. 173-187 (1976) 

26. Purification of immunoglobulin heavy chain messenger RNA by immunoprecipitation from the mouse myeloma tumor, MOPC-31C. Ono, M., Kondo, T., Kawakami, M. and Honjo, T. J. Biochem.(Tokyo) 81, 949-954 (1977) 

27. Existence of both kappa and lambda light chain messenger RNA sequences in mouse myeloma, MOPC-104E, known as a lambda chain producer. Ono, M., Kawakami, M., Kataoka, T. and Honjo, T. Biochem. Biophys.Res. Commun. 74, 796-802 (1977) 

28. Origin of immunoglobulin gene diversity: The evidence and a restrictionmodification model. Leder, P., Honjo, T., Seidman, J. and Swan, D. Cold Spring Harbor Symp. Quant. Biol. 41, 855-862 (1977) 

29. Accumulation of immunoglobulin messenger ribonucleic acid in immunized mouse spleen. Honjo, T., Shimizu, A., Tsuda, M., Natori, S., Kataoka, T., Dohmoto, C. and Mano, Y. Biochemistry 16, 5764-5769 (1977) 

30. The origin of diversity of immunoglobulin genes. Leder, P., Honjo, T. and Swan, D. The Organization and Expression of the Eukaryote Genome (ed. by E.M. Brandbury and K. Javaderline) Academic Press, New York. 421-436 (1977) 

31. Organization of immunoglobulin heavy chain genes and allelic deletion model. Honjo, T. and Kataoka, T. Proc. Natl. Acad. Sci. USA 75, 2140-2144(1978) 

32. Induced synthesis of immunoglobulin messenger RNA accompanies induction of immunoglobulin production in cultured mouse spleen cells. Tsuda, M., Honjo, T., Shimizu, A., Mizuno, D. and Natori, S. J. Biochem. (Tokyo) 84, 1285-1290 (1978) 

33. Purification and cloning of a ribosomal RNA gene fragment from mouse DNA. Mishima, Y., Sakai, M., Muramatsu, M., Kataoka, T. and Honjo, T. Proc. Japan Acad. 54, Ser. B, 657-662 (1978) 

34. Mutual homology of mouse immunoglobulin g-chain gene sequences. Yamawaki-Kataoka, Y., Sato, K., Shimizu, A., Kataoka, T., Mano, Y., Ono, M., Kawakami, M. and Honjo, T. Biochemistry 18, 490-494(1979) 

35. Organization and reorganization of immunoglobulin heavy chain genes-allelic deletion model. Honjo, T. and Kataoka, T. Oncogenic Viruses and Host Cell Genes (ed.by Y. Ikawa and T. Odaka) Academic Press, New York. 461-473 (1979) 

36. Cloning immunoglobulin g2b chain gene of mouse: characterization and partial sequence determination. Kataoka, T., Yamawaki-Kataoka, Y., Yamagishi, H. and Honjo, T. Proc. Natl. Acad. Sci. USA 76, 4240-4244 (1979) 

37. Cloning and complete nucleotide sequence of mouse immunoglobulin g1 chain gene. Honjo, T., Obata, M., Yamawaki-Kataoka, Y., Kataoka, T., Kawakami, T., Takahashi, N. and Mano, Y. Cell 18, 559-568 (1979) 

38. Comparison of immunoglobulin g1 and g2b chain gene cloned from newborn mouse evolutional divergence of intervening sequences and structural basis for recognition of splicing sites. Obata, M., Yamawaki-Kataoka, Y., Takahashi, N., Kataoka, T., Kawakami, T. and Honjo, T. Proc. Japan Acad. 55, Ser. B, 519-524 (1979) 

39. Immunoglobulin g1 heavy chain gene: structural gene sequences cloned in a bacterial plasmid. Obata, M., Yamawaki-Kataoka, Y., Takahashi, N., Kataoka, T., Shimizu, A., Mano, Y., Seidman, J. G., Peterlin, B. M., Leder, P. and Honjo, T. Gene 9, 87-97 (1980) 

40. Complete nucleotide sequence of immunoglobulin g2b chain gene cloned from newborn mouse DNA. Yamawaki-Kataoka, Y., Kataoka, T., Takahashi, N., Obata, M. and Honjo, T. Nature 283, 786-789 (1980) 

41. Rearrangement of immunoglobulin g1-chain gene and mechanism for heavy-chain class switch. Kataoka, T., Kawakami, T., Takahashi, N., and Honjo, T. Proc.Natl. Acad. Sci. USA 77, 919-923 (1980) 

42. Nucleotide sequence divergence of mouse immunoglobulin g1 and g2b chain genes and the hypothesis of intervening sequence-mediated domain transfer. Miyata, T., Yasunaga, T., Yamawaki-Kataoka, Y., Obata, M. and Honjo, T. Proc. Natl. Acad. Sci. USA 77, 2143-2147 (1980) 

43. Deletion of immunoglobulin heavy chain genes accompanies the class switch rearrangement. Yaoita, Y. and Honjo, T. Biomedical Res. 1, 164-175 (1980) 

44. Complete nucleotide sequence of mouse immunoglobulin m gene and comparison with other immunoglobulin heavy chain genes. Kawakami, T., Takahashi, N. and Honjo, T. Nucleic Acids Res. 8, 3933-3945 (1980) 

45. Nucleotide sequences of class-switch recombination region of the mouse immunoglobulin g2b-chain gene. Takahashi, N., Kataoka, T. and Honjo, T. Gene 11, 117-127 (1980) 

46. Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome. Yaoita, Y. and Honjo, T. Nature 286, 850-853 (1980) 

47. Untranslated immunoglobulin k light chain mRNA in a l light chain-producing mouse myeloma, MOPC104E. Kataoka, T., Ono, M., Kawakami, M., Ikawa, Y., Aida, M., Mano, Y. and Honjo, T. J. Biol. Chem. 255, 5291-5295 (1980) 

48. Cloning and determination of a putative promoter region of a mouse ribosomal deoxyribonucleic acid fragment. Mishima, Y., Kominami, R., Honjo, T., and Muramatsu, M. Biochemistry 19, 3780-3786 (1980) 

49. Induction and regulation of immunoglobulin expression in a murine pre-B cell line, 70Z/3. Sakaguchi, N., Kishimoto, T., Kikutani, H., Watanabe, T., Yoshida, N., Shimizu, A., Yamawaki-Kataoka, Y., Honjo, T. and Yamamura, Y. J. Immunology 125, 2654-2659 (1980) 

50. Cloning of human immunoglobulin m gene and comparison with mouse m gene. Takahashi, N., Nakai, S., and Honjo, T. Nucleic Acids Res. 8, 5983-5991 (1980) 

1981-1985

51. Ordering of mouse immunoglobulin heavy chain genes by molecular cloning. Shimizu, A., Takahashi, N., Yamawaki-Kataoka, Y., Nishida, Y., Kataoka, T. and Honjo, T. Nature, 289, 149-153 (1981) 

52. Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes. Kataoka, T., Miyata, T. and Honjo, T. Cell, 23, 357-368 (1981) 

53. Cloning of mouse immunoglobulin e gene and its location within the heavy chain gene cluster. Nishida, Y., Kataoka, T., Ishida, N., Nakai, S., Kishimoto, T., Bottcher, I. and Honjo, T. Proc. Natl. Acad. Sci. USA 78, 1581-1585 (1981) 

54. Organization and reorganization of immunoglobulin heavy-chain genes. Honjo, T., Kataoka, T., Yaoita, Y., Shimizu, A., Takahashi, N., Yamawaki-Kataoka, Y., Nikaido, T., Nakai, S., Obata, M., Kawakami,T. and Nishida, Y. Cold Spring Harbor Symp. Quant. Biol. 45,913-923 (1981) 

55. Structure of a rearranged g1 chain gene and its implication to immunoglobulin class-switch mechanism. Obata, M., Kataoka, T., Nakai, S., Yamagishi, H., Takahashi, N., Yamawaki-Kataoka, Y., Nikaido, T., Shimizu, A. and Honjo, T. Proc.Natl. Acad. Sci. USA 78, 2437-2441 (1981) 

56. The complete nucleotide sequence of mouse immunoglobulin g2a gene and evolution of heavy chain genes: further evidence for intervening sequence-mediated domain transfer. Yamawaki-Kataoka, Y., Miyata, T. and Honjo, T. Nucl. Acid. Res. 9, 1365-1381 (1981) 

57. Rearrangements of immunoglobulin genes during differentiation and evolution. Honjo, T., Nakai, S., Nishida, Y., Kataoka, T., Yamawaki-Kataoka,Y., Takahashi, N., Obata, M., Shimizu, A., Yaoita, Y., Nikaido, T. and Ishida, N. Immunol. Rev. 59, 33-67 (1981) 

58. Organization of immunoglobulin heavy chain genes and genetic mechanism of class switch. Takahashi, N., Shimizu, A., Obata, M., Nishida, Y., Nakai, S., Nikaido, T., Kataoka, T., Yamawaki-Kataoka, Y., Yaoita, Y., Ishida, N. and Honjo, T. Immunoglobulin Idiotypes (ed. C. Janeway, E. Sercarz and H. Wigzell) Academic Press, New York. 123-134 (1981) 

59. Switch region of the immunoglobulin Cmﾊ gene is composed of simple tandem repetitive sequences. Nikaido, T., Nakai, S. and Honjo, T. Nature 292, 845-848 (1981) 

60. Organization of immunoglobulin heavy chain genes and genetic mechanism for class switch. Honjo, T., Nishida, Y., Shimizu, A., Takahashi, N., Kataoka, T.,Obata, M., Yamawaki-Kataoka, Y., Nikaido, T., Nakai, S., Yaoita, Y.and Ishida, N. Recent Advances in Mucosal Immunity (ed. by W.Strober, L. A. Hanson and K. W. Sell) Raven Press, New York.173-187 (1982) 

61. The nucleotide sequences of rearranged and germline immunoglobulin VH genes of a mouse myeloma MC101 and evolution of VH genes in mouse. Kataoka, T., Nikaido, T., Miyata, T., Moriwaki, K., and Honjo, T. J. Biol. Chem. 257, 277-285 (1982) 

62. Japanese wild mouse, Mus musculus molossinus has duplicated immunoglobulin g2a genes. Shimizu, A., Hamaguchi, Y., Yaoita, Y., Moriwaki, K., Kondo, K. and Honjo, T. Nature 298, 82-84 (1982) 

63. The molecular mechanisms of the immunoglobulin class switch. Honjo, T. Immunol. Today 3, 214-217 (1982) 

64. Nucleotide sequences encoding membrane domains are conserved among immunoglobulin gamma subclass genes. Nakai, S., Oi, V., Herzenberg, L. A., Yamagishi, H. and Honjo, T. Biomedical Res. 3, 37-45 (1982) 

65. Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin g chains. Yamawaki-Kataoka, Y., Nakai, S., Miyata, T. and Honjo, T. Proc. Natl. Acad. Sci. USA. 79, 2623-2627 (1982) 

66. Organization of the constant-region gene family of the mouse immunoglobulin heavy chain. Shimizu, A., Takahashi, N., Yaoita, Y. and Honjo, T. Cell 28, 499-506 (1982) 

67. Cloning of human immunoglobulin e chain genes: Evidence for multiple Ce genes. Nishida, Y., Miki, T., Hisajima, H. and Honjo, T. Proc. Natl. Acad. Sci. USA 79, 3833-3837 (1982) 

68. Nucleotide sequences of switch regions of immunoglobulin Ce and Cg genes and their comparison. Nikaido, T., Yamawaki-Kataoka, Y. and Honjo, T. J. Biol. Chem. 257, 7322-7329 (1982) 

69. Structure of human immunoglobulin gamma genes: Implications for evolution of a gene family. Takahashi, N., Ueda, S., Obata, M., Nikaido, T. and Honjo, T. Cell 29, 671-679 (1982) 

70. Expression of lymphocyte surface IgE does not require switch recombination. Yaoita, Y., Kumagai, Y., Okumura, K. and Honjo, T. Nature 297, 697-700 (1982) 

71. Reconstitution of antigen-specific suppressor activity with translation products of mRNA. Taniguchi, M., Tokuhisa, T., Kanno, M., Yaoita, Y., Shimizu, A. and Honjo, T. Nature 298, 172-174 (1982) 

72. An antigen-specific suppressor T cell factor controlled by two genes in the immunoglobulin heavy chain linkage group and in the I-J subregion of the H-2 complex. Taniguchi, M., Tokuhisa, T., Kanno, M. and Honjo, T. Current Topics in Microbiology and Immunology, (ed. by M. Cooper, W. Henle, P. H. Hofschneider, H. Koprowski, F. Melchers, R. Rott, H. G. Schweiger, P. K. Vogt, R. Zinkernagel) 100, 33-41 (1982) 

73. Relationship between the rearrangement of immunoglobulin genes, the appearance of a B lymphocyte antigen, and immunoglobulin synthesis in murine pre-B cell lines. Sugiyama, H., Akira, S., Yoshida, N., Kishimoto, S., Yamamura, Y., Kincade, P., Honjo, T. and Kishimoto, T. J. Immunol. 126, 2793-2797 (1982) 

74. Immunoglobulin switch region-like sequences in Drosophila melanogaster. Sakoyama, Y., Yaoita, Y. and Honjo, T. Nucleic Acids Res. 10, 4203-4214 (1982) 

75. A T15-idiotype positive T suppressor hybridoma does not use the T15 VH gene segment. Nakanishi, K., Sugimura, K., Yaoita, Y., Maeda, K., Kashiwamura, S., Honjo, T. and Kishimoto, T. Proc. Natl. Acad. Sci. USA 79, 6984-6988 (1982) 

76. The nucleotide sequence of the mouse immunoglobulin epsilon gene:comparison with the human epsilon gene sequence. Ishida, N., Ueda, S., Hayashida, H., Miyata, T. and Honjo, T. EMBOJ. 1, 1117-1123 (1982) 

77. Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns. Ueda, S., Nakai, S., Nishida, Y., Hisajima, H. and Honjo, T. EMBOJ. 1, 1539-1544 (1982) 

78. Multiple DNA fragment polymorphisms associated with immunoglobulin m-switch-like regions in man. Migone, N., Feder, J., Cann, H., van West, B., Hwang, J.,Takahashi, N., Honjo, T. and Cavalli-Sforza, L. L. Proc. Natl. Acad. Sci. USA 80, 467-471 (1983) 

79. Escherichia coli extract-catalyzed recombination in switch regions of mouse immunoglobulin genes. Kataoka, T., Takeda, S. and Honjo, T. Proc. Natl. Acad. Sci. USA 80, 2666-2670 (1983) 

80. Molecular cloning and nucleotide sequencing of human epsilon chain cDNA. Seno, M., Kurokawa, T., Ono, Y., Onda, H., Sasada, R., Igarashi, K., Kikuchi, M., Sugino, Y., Nishida, Y. and Honjo, T. Nucl. Acid.Res. 11, 719-726 (1983) 

81. Organization and reorganization of constant region genes of immunoglobulin heavy chains: Genetic basis for class switching. Honjo, T., Ishida, N., kataoka, T., Nakai, S., Nikaido, T.,Nishida, Y., Noma, Y., Obata, M., Sakoyama, Y., Shimizu, A.,Takahashi, N., Takeda, S., Ueda, S., Yamawaki-Kataoka, Y. and Yaoita, Y. Nobel Symp. Genetics of the Immune Response (ed.Moller, E. and Moller G.) Plenum Publishing corporation 23-5 (1983) 

82. Immunoglobulin genes move during differentiation as well as evolution. Honjo, T., Kataoka, T., Takahashi, N., Shimizu, A., Ueda, S., Obata, M., Nikaido, T. and Takeda, S. Nucleic Acid Research (ed.Mizobuchi, K., Watanabe, I. and Watson, J. D.) Academic Press Inc.N.Y. 

83. Immunoglobulin genes. Honjo, T. Ann. Rev. Immunol. 1, 499-528 (1983) 

84. Structure of the human immunoglobulin Ce2 gene, a truncated pseudogene: Implications for its evolutionary origin. Hisajima, H., Nishida, Y., Nakai, S., Takahashi, N., Ueda, S. and Honjo, T. Proc. Natl. Acad. Sci. USA 80, 2995-2999 (1983) 

85. Human Immunoglobulin Genes. Nishida, Y., Ueda, S., Takahashi, N., Nakai, S., Hisajima, H., Barker, P. E., Ruddle, F. H. and Honjo, T. Humoral Factors in Host Defense (ed. Yamamura, Y., Hayashi, H. Honjo, T., Kishimoto, T., Muramatsu, M. and Osawa, T.) Academic Press 323-336 (1983) 

86. Expression of human immunoglobulin e chain cDNA in E.coli. Kurokawa, T., Seno, M., Sasada, R., Ono, Y., Onda, H., Igarashi, K., Kikuchi, M., Sugino, Y., and Honjo, T. Nucl. Acid. Res. 11, 3077-3085 (1983) 

87. Common terminal repeats of the macronuclear DNA are absent from the micronuclear DNA in hypotrichous ciliate, Stylonychia pustulata. Oka, Y., and Honjo, T. Nucl. Acid. Res. 11, 4325-4333 (1983) 

88. The complete nucleotide sequence of the influenza virus neuraminidasegene of A/NJ/8/76 strain and its evolution by segmental duplication and deletion. Miki, T., Nishida, Y., Hisajima, H., Miyata, T., Kumahara, Y., Nerome, K., Oya, A., Fukui, T., Ohtsuka, E., Ikehara, M. and Honjo, T. Mol. Biol. Med. 1, 401-413 (1983) 

89. Molecular mechanism of immunoglobulin gene rearrangement. Kataoka, T., Nishi, M., Kondo, S., Takeda, S. and Honjo, T. Progress in immunology V (ed. Yamamura, Y. and Tada, T.) Academic Press New York 123-133, (1983) 

90. The D-JH complex is an intermediate to the complete immunoglobulin heavy-chain V-region gene. Yaoita, Y., Matsunami, N., Choi, C. Y., Sugiyama, H., Kishimoto, T. and Honjo, T. Nucl. Acid. Res. 11, 7303-7316 (1983) 

91. The T-lymphocyte antigen receptor-an imaginary Monster ? Honjo, T. Scand. J. Immunol. 18, 83-85 (1983) 

92. Origin of adult T cell leukemia virus – Implication for its zoonosis. Fukui, K., Noma, T., Takeuchi, K., Kobayashi, N., Hatanaka, M. and Honjo, T. Mol. Biol. Med. 1, 447-456 (1983) 

93. First insights into the lymphocyte genome. Honjo, T. Immunol. Today, 18-19 (1983) 

94. Human immunoglobulin epsilon genes. Miki, T., Suzuki, N., Yamamura, K., Hisajima, H., Ueda, S.,Nishida, Y., Takahashi, N. and Honjo, T. Immunogenetics — ItsApplication to Clinical Medicine (eds. Sasazuki, T. and Tada, T.),227-238 (1984) 

95. Concerted evolution of the mouse immunoglobulin gamma chain genes. Hayashida, H., Miyata, T., Yamawaki-Kataoka, Y., Honjo, T., Wels, J. and Blattner, F. EMBO J. 3, 2047-2053 (1984) 

96. Genomic structure of HTLV (human T-cell leukemia virus): Detection of defective genome and its amplification in MT-2 cells. Kobayashi, N., Konishi, H., Sabe, H., Sigesada, K., Noma, T., Honjo, T. and Hatanaka, M. EMBO J. 3, 1339-1343 (1984) 

97. Rearranged immunoglobulin heavy chain variable region VH pseudogene that deletes the second complementarity determining region. Takahashi, N., Noma, T. and Honjo, T. Proc. Natl. Acad. Sci. USA 81, 5194-5198 (1984) 

98. Immunoglobulin class switching. Shimizu, A. and Honjo, T. Cell 36, 801-803 (1984) 

99. Epstein-barr virus transforms precursor B cells even before immuno-globulin gene rearrangement. Katamine, S., Otsu, M., Tada, K., Tsuchiya, S., Sato, T., Ishida, N., Honjo, T. and Ono, Y. Nature 309, 369-372 (1984) 

100. RNA splicing may be involved in a simultaneous production of two isotypes. Noma, Y., Yaoita, Y., Matsunami, N., Ros始, A., Klein, G. and Honjo, T. Regulation of the Immune System UCLA Symposia on Molecular and Cellular Biology, New Series, 18, (eds. Sercarz, E.,Cantor, H., and Chess, L.) Alan R. Liss, Inc., New York 491-496(1984) 

101. Introduction of human g1 immunoglobulin genes into fertilized mouse eggs. Yamamura, K., Kikutani, H., Takahashi, N., Taga, T., Shimizu, A.,Kawai, K., Fukuchi, K., Kumahara, Y., Honjo, T. and Kishimoto, T. J. Biochem. 96, 357-363 (1984) 

102. Evolution of immunoglobulin constant region gene family. Honjo, T., Miyata, T., Blattner, F. R., Hisajima, H., Nishida, Y., and Ueda, S. Genetics: New Frontiers III (Proceedings of the XV International Congress of Genetics), 287-291 (1984) 

103. Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein. Nonaka, M., Takahashi, M., Natsuume-Sakai, S., Nonaka, M., Tanaka, S., Shimizu, A. and Honjo, T., Proc. Natl. Acad. Sci. USA 81, 6822-6826 (1984) 

104. Isolation and characterization of endonuclease J: a sequence-specific endonuclease cleaving immunoglobulin genes. Kataoka, T., Kondo, S., Nishi, M., Kodaira, M. and Honjo, T. Nucl. Acid Res. 12, 5995-6010 (1984) 

105. Molecular cloning of cDNA encoding human interleukin-2 receptor. Nikaido, T., Shimizu, A., Ishida, N., Sabe, H., Teshigawara, K., Maeda, M., Uchiyama, T., Yodoi, J., and Honjo, T. Nature 311, 631-635 (1984) 

106. Duplicated immunoglobulin gamma 2a genes in wild mice. Fukui, K., Hamaguchi, Y., Shimizu, A., Nakai, S., Moriwaki, K., Wang, C. H., and Honjo, T. J. Mol. Cell. Immunol. 1, 321-330 (1984) 

107. Polymorphism in distribution and structure of P elements in natural populations of Drosophila melanogaster in and around Japan. Todo, T., Sakoyama, Y., Chigusa, S., Fukunaga, A., Honjo, T. and Kondo, S. Jpn. J. Genet. 59, 441-451 (1984) 

108. Polymorphisms of a human variable heavy chain gene show linkage with constant heavy chain genes. Johnson, M. J., Natali, A. M., Cann, H. M., Honjo, T. and Cavalli-Sforza, L. L. Proc. Natl. Acad. Sci. USA 81, 7840-7844 (1984) 

109. Immunoglobulin gene organization of UV-illuminated human lymphoblastoid cell lines producing both IgM and IgG. Noma, Y., Yaoita, Y., Matsunami, N., Ros, A., Klein, G. and Honjo, T. Mol. Bio. Med. 2, 337-350 (1984) 

110. Properties of human interleukin-2 receptors expressed on non-lymphoid cells by cDNA transfection. Sabe, H., Kondo, S., Shimizu, A., Tagaya, Y., Yodoi, J., Kobayashi, N., Hatanaka, M., Matsunami, N., Maeda, M. Noma, T., and Honjo, T. Mol. Biol. Med. 2, 379-396 (1984) 

111. Structures of defective P transposable elements prevalent in natural Q and Q-derived M strains of Drosophila melanogaster. Sakoyama, Y., Todo, T., Ishiwa-Chigusa, S., Honjo, T. and Kondo, S. Proc. Natl. Acad. Sci. USA 82, 6236-6239 (1985) 

112. Endonuclease J: A site-specific endonuclease cleaving immunoglobulin genes. Kondo, S., Kataoka, T., Nishi, M., Kodaira, M., Takeda, S., and Honjo, T. Cold Spring Harbor Symposia on Quantitative Biology 49, 661-668 (1985) 

113. Introduction of mouse Ce genes into Cos-7 cells and fertilized mouse eggs. Yamamura, K., Miki, T., Suzuki, N., Ebihara, T., Kawai, K., Kumahara, Y., and Honjo, T. J. Biochem. 97, 333-339 (1985) 

114. Construction of chimaeric processed immunoglobulin genes containing mouse variable and human constant region sequences. Takeda, S., Naito, T., Hama, K., Noma, T. and Honjo, T. Nature 314, 452-454 (1985) 

115. Nucleotide sequence of mouse IL-2 receptor cDNA and its comparison with the human IL-2 receptor sequence. Shimizu, A., Kondo, S., Takeda, S., Yodoi, J., Ishida, N., Sabe, H., Osawa, H., Diamantstein, T., Nikaido, T. and Honjo, T. Nucl. Acid. Res. 13, 1505-1516 (1985) 

116. Rat lymphoid cell lines producing human T cell leukemia virus. Yodoi, J., Okada, M., Tagaya, Y., Teshigawara, K., Fukui, K., Ishida, N., Ikuta, K., Maeda, M., Honjo, T., Osawa, H., Diamantstein, T., Tateno, M. and Yoshiki, T. J. Exp. Med. 161, 924-934 (1985) 

117. A truncated immunoglobulin e pseudogene is found in gorilla and man but not in chimpanzee. Ueda, S., Takenaka, O. and Honjo, T. Proc. Natl. Acad. Sci. USA 82, 3712-3715 (1985) 

118. TCGF (IL 2)-receptor inducing factor (S)1. regulation of IL-2 receptor on a natural killer-like cell line (YT cells). Yodoi, J., Teshigawara, K., Nikaido, T., Fukui, K., Noma, T., Honjo, T., Takigawa, M., Sasaki, M., Minato, N., Tsudo, M.,Uchiyama, T., and Maeda, M. J. Immunol. 134, 1623-1630 (1985) 

119. Low frequency of somatic mutation in b-chain variable region genes of human T-cell receptors. Ikuta, K., Ogura, T., Shimizu, A. and Honjo, T. Proc. Natl. Acad. Scid. USA 82, 7701-7705 (1985) 

120. Preferential rearrangement of the immunoglobulin K chain joining region JK1 and JK2 segments in mouse spleen DNA. Nishi, M., Kataoka, T. and Honjo, T. Proc. Natl. Acad. Sci. USA 82, 6399-6403 (1985) 

121. Origin of immune diversity-genetic variation and selection. Honjo, T. and Habu, S. Ann. Rev. Biochem. 54, 803-830 (1985) 

122. Molecular cloning and structure of the human interleukin 2 receptor gene. Ishida, N., Kanamori, H., Noma, T., Nikaido, T., Sabe, H., Suzuki, N., Shimizu, A. and Honjo, T. Nucl. Acid. Res. 13, 7579-7589 (1985) 

123. Absence of gross change in primary DNA sequence during aging process of mice. Ono, T., Okada, S., Kawakami, T., Kominami, R., Honjo, T., and Getz, M. J. Mechanisms of Aging & Development 32, 227-234 (1985) 

124. Origin of human T-lymphotrophic virus I-positive T-cell lines in adult T-cell leukemia Maeda, M., Shimizu, A., Ikuta, K., Okamoto, H., Kashihara, M., Uchiyama, T., Honjo, T. and Yodoi, J. J. Exp. Med. 162, 2169-2174 (1985) 

125. TCGF(IL 2)-receptor inducing factor(S)II. possible role of ATL-derived factor (ADF) on constitutive IL 2 receptor expression of HTLV-I[+] T cell lines. Okada, M., Maeda, M., Tagaya, Y., Taniguchi, Y., Teshigawara, K.,Yoshiki, T., Diamantstein, T., Smith, A. K., Uchiyama, T., Honjo, T. and Yodoi, J. J. Immunol. 135, 3995-4003 (1985) 

126. Lymphokines and receptors: roles in clonal selection of lymphocytes. Kondo, S., Shimizu, A., Maeda, M., Tagaya, Y., Yodoi, J., and Honjo, T. Proceeding of the First Japan-Italy Joint Seminar on Biological Sciences. Introduction and Expression of Recombinanant DNA in plants and Aminols, 53-55 (1985) 

1986-1990

127. Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. Noma, Y., Sideras, P., Naito, T., Bergstedt-Lindquist, S., Azuma, C., Severinson, E., Tanabe, T., Kinashi, T., Matsuda, F., Yaoita, Y. and Honjo, T. Nature 319, 640-646 (1986) 

128. Expression of functional human interleukin 2 receptor in mouse T cells by cDNA transfection. Kondo, S., Shimizu, A., Maeda, M., Tagaya, Y., Yodoi, J. and Honjo, T. Nature 320, 75-77 (1986) 

129. An anonymous single copy chromosome 18 probe associated with a frequent RFLP. Tateishi, H., Nishisho, I., Miki, T., Takai, S. and Honjo, T. Nucl. Acid. Res. 14, 1926 (1986) 

130. Expression of interleukin 2 receptors on interleukin 3-dependent cell lines. Koyasu, S., Yodoi, J., Nikaido, T., Tagaya, Y., Taniguchi, Y., Honjo, T. and Yahara I. J. Immunol. 136, 984-987 (1986) 

131. Preferential transcription of HTLV-I LTR in cell-free extracts of human T cells producing HTLV-I viral proteins. Matsunami, N., Siomi, H., Hatanaka, M., Yaoita, Y. and Honjo, T. Nucl. Acid. Res. 14, 4779-4786 (1986) 

132. A joining-diversity-joining complex generated by inversion mechanism and a variable-diversity complex in the b-chain gene of the human T-cell receptor. Ikuta, K., Ogura, T., Shimizu, A. and Honjo, T. Nucl. Acids Res. 14, 4899-4909 (1986) 

133. Cytochemical, Immunologic, Chromosomal, and Molecular Genetic Analysis of a Novel Cell Line Derived from Hodgkin’s Disease. Kamesaki, H., Fukuhara, S., Tatsumi, E., Uchino, H., Yamabe, H.,Miwa, H., Shirakawa, S., Hatanaka, M. and Honjo, T. Blood 68, 285-292 (1986) 

134. Structure and function of the interleukin 2 receptor: affinity conversion model. Shimizu, A., Kondo, S., Sabe, H., Ishida, N. and Honjo, T. Immunol. Rev. 92, 103-120 (1986) 

135. Organization and evolution of variable region genes of the human immunoglobulin heavy chain. Kodaira, M., Kinashi, T., Umemura, I., Matsuda, F., Noma, T., Ono, Y. and Honjo, T. J. Mol. Biol. 190, 529-541 (1986) 

136. Gene patterns of immunoglobulin heavy chain in various cell lines and lymphoid malignancies. Miwa, H., Kita, K., Ohno, T., Tanaka, I., Shirakawa, S., Doi, S., Kamesaki, H., Honjo, T. and Hatanaka, M. Acta Haematologica Japonica 49, 1188-1194 (1986) 

137. Expression and rearrangement of the a, b, and g chain genes of the T cell receptor in cloned murine large granular lymphocyte lines: no correlation with the cytotoxic spectrum. Ikuta, K., Hattori, M., Wake, K., Kano, S., Honjo, T., Yodoi, J. and Minato, N. J. Exp. Med. 164, 428-442 (1986) 

138. Interleukin 1a mRNA in virus-transformed T and B Cells. Noma, T., Nakamura, T., Maeda, M., Okada, M., Taniguchi, Y., Tagaya, Y., Yaoita, Y., Yodoi, J. and Honjo, T. Biochem. Biophy. Res. Commun. 139, 353-360 (1986) 

139. Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II. Kinashi, T., Harada, N., Severinson, E., Tanabe, T., Sideras, P., Konishi, M., Azuma, C., Tominaga, A., Bergstedt-Lindqvist, S., Takahashi, M., Matsuda, F., Yaoita, Y., Takatsu, K. and Honjo, T. Nature 324, 70-73 (1986) 

140. Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue. Azuma, C., Tanabe, T., Konishi, M., Kinashi, T., Noma, T., Matsuda,F., Yaoita, Y., Takatsu, K., Hammarstr嗄, L., Smith, E., Severinson, E. and Honjo, T. Nucl. Acid. Res. 14, 9149-9158 (1986) 

141. Molecular basis for two different affinity states of the interleukin 2 receptor: affinity conversion model. Kondo, S., Shimizu, A., Saito, Y., Kinoshita, M. and Honjo, T. Proc. Natl. Acad. Sci. USA 83, 9026-9029 (1986) 

142. Isolation of DNA clones revealing restriction fragment length polymorphisms in the human genome. Nishisho, I., Miki, T., Tateishi, H., Takai, S., Motomura, K., Nakura, J., Kumahara, Y., Mori, T. and Honjo, T. Jpn. J. Human Genet. 31, 249-258 (1986) 

143. Hominoid evolution based on the structures of immunoglobulin epsilon and alpha genes. Ueda, S., Watanabe, Y., Hayashida, H., Miyata, T., Matsuda, F. and Honjo, T. Cold Spring Harbor 51, 429-432 (1986)

144. Production and characterization of the extracytoplasmic portion of the human interleukin-2 receptor. Shimizu, A., Kondo, N., Kondo, S., Hamuro, J. and Honjo, T. Mol. Biol. Med. 3, 509-520 (1986) 

145. Interleukin 2 receptor: structure, function and expression. Kanamori, H., Kondo, S., Kinoshita, M., Suzuki, N., Saito, Y., Sabe, H., Matsunami, N., Ishida, N., Shimizu, A. and Honjo, T. Cold Spring Harbor Symposia on Quantitative Biology 51, 739-749 (1986) 

146. The T-cell receptor gene rearrangements in T-lineage tumors without OKT-3, 4, 6, 8 markers. Miwa, H., Konishi, H., Kobayashi, N., Kita, K., Shirakawa, S., Shimizu, A., Honjo, T. and Hatanaka, M. J. Mol. Cell. Immunol. 3, 37-42 (1987) 

147. Relationship of human cord blood mononuclear cell lines, established by the HTLV-I integration, to expression of T-cell phenotypes and the T-cell receptor gene rearrangement. Miwa, H., Uchida, T., Kobayashi, T., Kita, K., Shirakawa, S., Koyanagi, Y., Yamamoto, N., Shimizu, A., Honjo, T. and Hatanaka, M. J. Mol. Cell. Immunol. 3, 43-48 (1987) 

148. Analysis of steroid 21-hydroxylase gene in five unrelated japanese patients with 21-hydroxylase deficiency. Nakura, J., Miki, T., Fukuchi, K., Shimizu, K., Nose, O., Takai, S., White, P. C., Honjo, T. and Kumahara, Y. Endocrinologia Japonica 34, No.3 373-379 (1987) 

149. IgG1 induction factor: a single molecular entity with multiple biological functions. Sideras, P., Bergstedt-Lindqvist, S., and Severinson, E., Noma, Y., Naito, T., Azuma, C., Tanabe, T., Kinashi, T., Matsuda, F., Yaoita, Y. and Honjo, T. Mechanisms of Lymphocyte Activation and ImmuneRegulation (edited by S. Gupta, W. E. Paul, and A. S. Fauci, Plenum Publishing Corporation), 227-236 (1987) 

150. IL-2 Receptor gene activation by ATL-derived factor (ADF) Yodoi, J., Okada, M., Tagaya, Y., Taniguchi, Y., Teshigawara, K., Kasahara, T., Dinarello, C. A., Matsuhima, K., Honjo, T., Uchiyama, T. and Maeda, M. Mechanisms of Lymphocyte Activation and Immune Regulation (edited by S. Gupta, W. E. Paul, and A. S. Fauci, Plenum Publishing Corporation), 139-148 (1987) 

151. Interleukin 4 (IgG1 induction factor): a multifunctional lymphokine acting also on T cells. Severinson, E., Naito, T., Tokumoto, H., Fukushima, D., Hirano, A., Hama, K. and Honjo, T. Eur. J. Immunol. 17, 67-72 (1987) 

152. Interleukin 4 as an essential factor for in vitro clonal growth of murine connective tissue-type mast cells. Hamaguchi, Y., Kanakura, Y., Fujita, J., Takeda, S., Nakano, T., Tarui, S., Honjo, T. and Kitamura, Y. J. Exp. Med. 165, 268-273(1987) 

153. Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins. Ikuta, K., Takami, M., Kim, C. W., Honjo, T., Miyoshi, T., Tagaya,Y., Kawabe, T. and Yodoi, J. Proc. Natl. Acad. Sci. USA 84, 819-823 (1987) 

154. Nucleotide sequences of immunoglobulin e genes of chimpanzee and orang utan: DNA molecular clock and hominoid evolution. Sakoyama, Y., Hong, K. J., Byun, S. M., Hisajima, H., Ueda, S., Yaoita, Y., Hayashida, H., Miyata, T. and Honjo, T. Proc. Natl. Acad. Sci. USA 84 1080-1084 (1987) 

155. Molecular characterization of novel reciprocal translocation t(6;14) in an Epstein-Barr virus-transformed B cell precursor. Otsu, M., Katamine, S., Uno, M., Yamaki, M., Ono, Y., Klein, G.,Sasaki, M., Yaoita, Y. and Honjo, T. Mol. Cell. Bio. 7, 708-717 (1987) 

156. The human IL-2 receptor gene contains a positive regulatory element that functions in cultured cells and cell-free extracts. Suzuki, N., Matsunami, N., Kanamori, H., Ishida, N., Shimizu, A., Yaoita, Y., Nikaido, T. and Honjo, T. J. Biol. Chem. 262, 5079-5086 (1987) 

157. Production of a monoclonal antibody useful in the molecular characterization of murine T-cell-replacing factor / B-cell growth factor II. Harada, N., Takahashi, T., Matsumoto, M., Kinashi, T., Ohara, J., Kikuchi, Y., Koyama, N., Severinson, E., Yaoita, Y., Honjo, T., Yamaguchi, N., Tominaga, A. and Takatsu, K. Proc. Natl. Acad. Sci. USA 84, 4581-4585 (1987) 

158. Regulatory expression of the human interleukin-2 receptor gene: molecular basis for clonal expansion of lymphocytes. Matsunami, N., Kanamori, H., Suzuki, N. and Honjo, T. Integration and Control of Metabolic Processes: pure and applied aspects (edited by O. L. Kon, ICSU Cambridge press) 197-209 (1987) 

159. A novel family of variable region genes of the human immunoglobulin heavy chain. Lee, K. H., Matsuda, F., Kinashi, T., Kodaira, M. and Honjo, T. J. Mol. Biol. 195, 761-768 (1987) 

160. Structure and function of interleukins 4 and 5. Honjo, T., Yaoita, Y., Kinashi, T., Noma, Y., Naito, T., Azuma, C., Severinson, E., Sideras, P., Bergstedt-Lindqvist, S., Takatsu, K., Tominaga, A., Harada, N., Tanabe, T., Konishi, M., Takahashi, M. and Matsuda, F. Acta Paediatrica Japonica 29, 546-551 (1987) 

161. Human neoplastic B cells express more than two isotypes of immunoglobulins without deletion of heavy-chain constant region genes. Kinashi, T., Godal, T., Noma, Y., Ling, N. R., Yaoita, Y. and Honjo, T. Genes and Development 1, 465-470 (1987) 

162. Expression and functional characterization of artificial mutants of interleukin-2 receptor. Kondo, S., Kinoshita, M., Shimizu, A., Saito, Y., Konishi, M., Sabe, H. and Honjo, T. Nature 327, 64-67 (1987) 

163. T cell replacing factor/interleukin 5 induces not only B-cell growth and differentiation, but also increased expression of interleukin 2 receptor on activated B-cells. Harada, N., Matsumoto, M., Koyama, N., Shimizu, A., Honjo, T., Tominaga, A. and Takatsu, K. Immunol. Lett. 15, 205-215 (1987) 

164. Transcription of IL-2 receptor gene is stimulated by ATL-derived factor produced by HTLV-I(+) T cell lines. Tagaya, Y., Taniguchi, Y., Naramura, M., Okada, M., Suzuki, N., Kanamori, H., Nikaido, T., Honjo, T. and Yodoi, J. Immunol. Lett. 15, 221-228 (1987) 

165. Enhancement of the interleukin 2 receptor expression on T-cells by multiple B-Lymphotropic Lymphokines. Noma, T., Mizuta, T., Rosen, A., Hirano, T., Kishimoto, T. and Honjo, T. Immunol. Lett. 15, 249-253 (1987) 

166. Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes. Takatsu, K., Kikuchi, Y., Takahashi, T., Honjo, T., Matsumoto, M., Harada, N., Yamaguchi, N. and Tominaga, A. Proc. Natl. Acad. Sci. USA 84, 4234-4238 (1987) 

167. Molecular genetic studies on the interleukin 2 receptor. Sabe, H., Kondo, S., Noma, T. and Honjo, T. Recent Advances in Leukemia and Lymphoma (eds. Gale, R. P. and Golde, D. W., Alan R. Liss Inc.) 61, 303-312 (1987) 

168. Evidence for the interleukin-2 dependent expansion of leukemic cells in adult T cell leukemia. Maeda, M., Arima, N., Daitoku, Y., Kashihara, M., Okamoto, H., Uchiyama, T., Shirono, K., Matsuoka, M., Hattori, T., Takatsuki, K., Ikuta, K., Shimizu, A., Honjo, T. and Yodoi, J. Blood 70, 1407-1411 (1987) 

169. Loss of genes on chromosome 22 in medullary thyroid carcinoma and pheochromocytoma. Takai, S., Tateishi, H., Nishisho, I., Miki, T., Motomura, K., Miyauchi, A., Kato, M., Ikeuchi, T., Yamamoto, K., Okazaki, M., Yamamoto, M., Honjo, T., Kumahara, Y. and Mori, T. Jpn. J. Cancer Res. (Gann) 78, 894-898 (1987) 

170. Regulation of murine IgE production in SJA/9 and nude mice:potentiation of IgE production by recombinant interleukin 4. Azuma, M., Hirano, T., Miyajima, H., Watanabe, N., Yagita, H., Enomoto, S., Furusawa, S., Ovary, Z., Kinashi, T., Honjo, T. and Okumura K. J. Immunol. 139, 2538-2544 (1987) 

171. Interleukin 2 receptor. Yodoi, J., Shimizu, A., Sabe, H. and Honjo, T. The Molecular Biology of Receptors, Techniques and Applications of Receptor Research, (Edited by A. D. Strosberg, Ellis Horwoad Limited)187-209 (1987) 

172. Molecular cloning and structure of the human interleukin 5 gene. Tanabe, T., Konishi, M., Mizuta, T., Noma, T. and Honjo, T. J. Biol. Chem. 262, 16580-16584 (1987) 

173. Growth factors and receptors of lymphocytes. Kinashi, T., Noma, Y., Azuma, C., Kondo, S., Tanabe, T., Konishi, M., Kinoshita, M., Takahashi, M., Saito, Y., Ogura, T., Sabe, H., Shimizu, A., Yaoita, Y. and Honjo, T. Acta Neurochirurgica, Suppl. 41, 118-125 (1987) 

174. Nucleotide sequences of variable region segments of the immunoglobulin heavy chain of Xenopus laevis. Yamawaki-Kataoka, Y. and Honjo, T. Nucl. Acid. Res. 15, 5888 (1987) 

175. Lymphoma cell line (FL-18) and Epstein-Barr virus-carrying cell line(FL-18-EB) obtained from a patient with follicular lymphoma:monoclonal derivation and different properties. Doi, S., Ohno, H., Tatsumi, E., Arita, Y., Kamesaki, H., Fukuhara, S., Nishikori, M., Miwa, H., Kita, K., Hatanaka, M., Honjo, T., Fujii, H., Uchino, H. Blood 70, 1619-1623 (1987) 

176. Multiple recombinational events in primate immunoglobulin epsilon and alpha genes suggest closer relationship of humans to chimpanzees than to gorillas. Ueda, S., Matsuda, F., and Honjo, T. J. Mol. Evol. 27, 77-83(1988) 

177. Both B151-TRF-1 and IL-5 regulate Ig secretion and IL-2 receptor expression on a cloned B lymphoma line. Nakanishi, K., Yoshimoto, T., Katoh, Y., Ono, S., Matsui, K., Hiroishi, K., Noma, T., Honjo, T., Takatsu, K., Higashino, K., and Hamaoka, T. J. Immunology 140, 1168-1174 (1988) 

178. Differentiation of an interleukin 3-dependent precursor B-cell clone into immunoglobulin-producing cells in vitro. Kinashi, T., Inaba, K., Tsubata, T., Tashiro, K., Palacios, R., and Honjo, T. Proc. Natl. Acad. Sci. USA 85, 4473-4477 (1988) 

179. Differentiation of a precursor cell with the germline context of immunoglobulin gene into immunoglobulin-producing cells in vitro. Kinashi, T., Inaba, K., Tsubata, T., Tashiro, K., Palacios, R., and Honjo, T. The Annals of the New York Academy of Sciences. 546 1-8 (1988) 

180. Molecular mechanism for the formation of the high-affinity complex of interleukin 2 and its receptor. Ogura, T., Konishi, M., Suzuki, N., Kondo, S., Sabe, H., and Honjo, T. Mol. Biol. Med. 5, 123-138 (1988) 

181. Mouse immunoglobulin allotypes: multiple differences between the nucleic acid sequences of the IgEa and IgEb alleles. Shinkai, Y., Nakauchi, H., Honjo, T., and Okumura, K. Immunogenetics 27, 288-292 (1988) 

182. Structure and function of interleukin 4 and 5. Sideras, P. Noma, T. and Honjo, T. Immunol. Rev. 102, 189-212 (1988) 

183. Human immunoglobulin D segments: isolation of a new D segment and polymorphic deletion of the D1 segment. Zong, S. Q. Nakai, S., Matsuda, F., Lee, K. H., and Honjo, T. Immunol. Lett. 17, 329-334 (1988) 

184. Loss of genes on the long arm of chromosome 22 in human meningiomas. Okazaki, M., Nishisho, I., Tateishi, H., Motomura, K., Yamamoto, M., Miki, T., Hayakawa, T., Takai, S., Honjo, T., and Mori, T. Mol. Biol. Med. 5, 15-22 (1988) 

185. Dispersed localization of D segments in the human immunoglobulin heavy chain locus. Matsuda, F., Lee, K. H., Nakai, S., Sato, T., Kodaira, M., Zong, S. Q., Ohno, H., Fukuhara, S., and Honjo, T. EMBO J. 7, 1047-1051 (1988) 

186. A larger number of L chains (Tac) enhance the association rate of interleukin 2 to the high affinity site of the interleukin 2 receptor. Saito, Y., Sabe, H., Suzuki, N., Kondo, S., Ogura, T., Shimizu, A., and Honjo, T. J. Exp. Med. 168, 1563-1572 (1988) 

187. Phenotypic conversion of T lymphoblastic lymphoma to acute biphenotypic leukemia composed of lymphoblasts and myeloblasts. Nosaka, T., Ohno, H., Doi, S., Fukuhara, S., Miwa, H., Kita, K., Shirakawa, S., Honjo, T., and Hatanaka, M. J. Clin. Invest. 81, 1824-1828 (1988) 

188. Plasma cell leukemia of non-producer type with missing light chain gene rearrangement. Tominaga, N., Katagiri, S., Hamaguchi, Y., Nishiura, T., Kanakura, Y., Kanayama, Y., Nagao, K., Kakiuchi, Y., Nishida, K., Abe, T., Honjo, T., Yonezawa, T., and Tarui, S. British Journal of Haematology 69, 213-218 (1988) 

189. Immunogenotypes of lymphoid malignancies; the rearrangement of T cell receptor b chain gene can occur before the g chain gene rearrangement. Miwa, H., Nosaka, T., Kita, K., Ohno, T., Matsuoka, N., Shirakawa, S., Arita, Y., Doi, S., Nishikori, M., Honjo, T. and Hatanaka, M. Jpn. J. Cancer Res. (Gann), 79, 484-490 (1988) 

190. Establishment of a peripheral T-cell lymphoma cell line showing amplification of the c-myc oncogene. Ohno, H., Fukuhara, S., Arita, Y., Doi, S., Takahashi, R., Fujii, H., Honjo, T., Sugiyama, T. and Uchino, H. Cancer Res. 48, 4959-4963 (1988) 

191. Biased expression of variable region gene families of the immunoglobulin heavy chain in autoimmune-prone mice. Yaoita, Y., Takahashi, M., Azuma, C., Kanai, Y. and Honjo, T. J. Biochem. 104, 337-343 (1988) 

192. Loss of alleles at loci on chromosome 13 in human primary gastric Cancers. Motomura, K., Nishisho, I., Takai, S., Tateishi, H., Okazaki, M., Yamamoto, M., Miki, T., Honjo, T. and Mori, T. Genomics 2, 180-184(1988) 

193. Expression of functional interleukin-2 receptors in human light chain/Tac transgenic mice. Nishi, M., Ishida, Y., and Honjo, T. Nature 331, 267-269 (1988) 

194. Introduction and expression of the interleukin 2 receptor (Tac) gene in hematopoietic stem cells with retrovirus vectors. Takeda, S., Hamaguchi, Y., Zong, S. Q., Kuze, K., and Honjo, T. Growth Factors 1, 59-66 (1988) 

195. Effect of human recombinant interleukin-5 and G-CSF on eosinophil colony formation. Enokihara, H., Nagashima, S., Noma, T., Kajitani, H., Hamaguchi, H., Saito, K., Furusawa, S., Shishido, H. and Honjo, T. Immunol. Lett. 18, 73-76 (1988) 

196. Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive peyer’s patch B cells. Beagley, K. W., Eldridge, H., Kiyono, H., Everson, M. P., Koopman, W. J. and Honjo, T. and McGhee, J. R. J. Immunol. 141, 2035-2042 (1988) 

197. Macrophages phagocytose thymic lymphocytes with productively rearranged T cell receptor a and b genes. Inaba, K., Inaba, M., Kinashi, T., Tashiro, K., Witmer-Pack, M., Crowley, M., Kaplan, G., Valinsky, J., Romani, N., Ikehara, S., Muramatsu, S., Honjo, T. and Steinman, R. M. J. Exp. Med. 168, 2279-2294 (1988)

198. A new progression factor for stimulation of human B cells in vitro. Rosen, A., Noma, T., Wendel-Hansen, V., Zeuthen, J., Lin, C.-Y. and Honjo, T. In Vitro Immunization in Hybridoma Technology, Elsevier Science Pulishers B.V., Edited by C.A.K. Borrebaech 311-317 (1988) 

199. Fibroblast-dependent growth of mouse mast cells in vitro:duplication of mast cell depletion in mutant mice of W/Wv genotype. Fujita, J., Nakayama, H., Onoue, H., Kanakura, Y., Nakano, T., Asai, H., Takeda, S, Honjo, T. and Kitamura, Y. J. Cellular Physiology 134, 78-84 (1988) 

200. Application of a human T cell line derived from a Sezary syndrome patient for human Interleukin 4 assay. Maeda, M., Noma,T., Hama, K. and Honjo, T. Immunol. Lett. 18, 247-254 (1988) 

201. A unique monoclonal antibody derived from a lupus-prone mouse with multiple bindings to autoantigens associated with rheumatic disease. Kanai, Y., Yaoita, Y., Imaoka, K. and Honjo, T. Immunol. Lett. 19, 15-20 (1988) 

202. A soluble anchorminus interleukin 2 receptor suppresses in vitro interleukin 2-mediated immune responses. Kondo, N., Kondo, S., Shimizu, A., Honjo, T. and Hamuro, J. Immunol. Lett. 19, 299-308 (1988) 

203. Physical linkage of a variable region segment and the joining region segment of the human immunoglobulin heavy chain locus. Sato, T., Matsuda, F., Lee, K. H., Shin, E. K. and Honjo, T. Biochemical and Biophysical Research Communications 154, 265-271 (1988) 

204. Molecular cloning and structure of the mouse interleukin-5 gene. Mizuta, T R., Tanabe, T., Nakakubo, H., Noma, T. and Honjo, T. Growth Factors 1, 51-57 (1988) 

205. An interleukin-4-dependent precursor clone is an intermediate of the differentiation pathway from an interleukin-3-dependent precursor clone into myeloid cells as well as B lymphocytes. Kinashi, T., Tashiro, K., Inaba, K., Takeda, T., Palacios, R. and Honjo, T. Int. Immunol. 1, 11-19 (1989) 

206. A New vector and RNase H method for the subtractive hybridization. Kuze, K., Shimizu, A. and Honjo, T. Nucl. Acid. Res. 17, 807 (1989) 

207. Multiple effects of human recombinant interleukin 4 on human myeloid monocyte cell lines. Noma, T., Nakakubo, H., Hama, K. and Honjo, T. Immunol. Lett. 21, 323-328 (1989) 

208. Nucleotide sequences of immunoglobulin-epsilon pseudogenes in man and apes and their phylogenetic relationships. Ueda, S., Watanabe, Y., Saitou, N., Omoto, K., Hayashida, H., Miyata, T., Hisajima, H. and Honjo, T. J. Mol Biol. 205, 85-90 (1989) 

209. Chromosomal mapping of the mouse IL-4 and human IL-5 genes. Takahashi, M., Yoshida, M., Satoh, H., Hilgers, J., Yaoita, Y. and Honjo, T. Genomics 4, 47-52 (1989) 

210. Immunological abnormalities in human interleukin-2 or interleukin-2/interleukin-2 receptor L chain transgenic mice. Nishi, M., Ishida, Y., Inaba, K., Suzuki, S., Taguchi, O., Sideras, P., Takeuchi, E., Yoshida, H., Kawaichi, M. and Honjo, T. Mechanisms of Action and Therapeutic Applications of Biologicals inCancer and Immune Deficiency Disorders, Alan R. Liss, Inc. 175-186(1989) 

211. Constant region genes of the immunoglobulin heavy chain and the molecular mechanism of class switching. Honjo, T., Shimizu, A. and Yaoita, Y. Immunoglobulin Genes,Academic Press Limited, Edited by T. Honjo, T W. Alt, and T H.Rabbitts. 123-149 (1989) 

212. Characterization of high-affinity receptors for IL-5 on IL-5 dependent cell lines. Mita, S., Tominaga, A., Hitoshi, Y., Sakamoto, K., Honjo, T., Akagi, M., Kikuchi, Y., Yamaguchi, N. and Takatsu, K. Proc. Natl. Acad. Sci. USA 86, 2311-2315 (1989) 

213. Cross-lineage gene rearrangements in human leukemic B-precursor cells occur frequently with V-DJ rearrangements of IgH genes. Nosaka, T., Kita, K., Miwa, H., Kawakami, K., Ikeda T., Ohno, T., Matsuoka, N, Arita, Y., Doi, S., Nishikori, M., Matsuda, F., Lee, K H., Shirakawa, S., Honjo, T. and Hatanaka, M. Blood 74, 361-368 (1989) 

214. Production of sterile transcripts of Cg genes in an IgM-producting human neoplastic B cell line that switches to IgG-producing cells. Sideras, P., Mizuta T R., Kanamori, H., Suzuki, N., Okamoto, M., Kuze, K., Ohno, H., Doi, S., Fukuhara, S., Hassan, M S., Hammarstrom, L., Smith, E., Shimizu, A. and Honjo, T. Int. Immunol. 1, 631-642 (1989) 

215. Rapid methods for purification of human recombinant interleukin-5 (IL-5)using the anti-murine IL-5 antibody-coupled immunoaffinity column. Mita, S., Hosoya, Y., Kubota, I., Nishihara, T., Honjo, T., Takahashi, T. and Takatsu, K. J. Immunological Methods 125, 233-241 (1989) 

216. Effect of Human Recombinant interleukin 4 on in vitro granulopoiesis of human bone marrow cells. Kajitani, H., Enokihara, H., Tsunogake, S., Takano, N., Saito, K., Furusawa, S., Shishido, H., Noma, T., Shimizu, A. and Honjo, T., Growth Factors 1, 283-286 (1989) 

217. Transcriptional regulation alone does not explain the constitutive expression of the interleukin 2 receptor (Tac/L-chain) in HTLV-1 infected cells. Kanamori, H., Suzuki, N., Ishida, N. and Honjo, T. Immunol. Lett. 20, 293-298 (1989) 

218. Involvement of c-myc oncogene in lymphoma cell lines with no detectable chromosome rearrangement of band 8q24. Ohno, H., Fukuhara, S., Doi, S., Amakawa, R., Horii, M., Akiyama, Y., Fukuda, W., Honjo, T., Sugiyama, T. and Uchino, H. Cancer Genet. Cytogenet 40, 73-82 (1989) 

219. Effects of the deregulated expression of human interleukin-2 in transgenic mice. Ishida, Y., Nishi, M., Taguchi, O., Inaba, K., Minato, N., Kawaichi, M. and Honjo, T. Int. Immunol. 1, 113-120 (1989) 

220. Expansion of natural killer cells but not T cells in human IL-2/IL-2 receptor (Tac) transgenic mice. Ishida, Y., Nishi, M., Taguchi, O., Inaba, K., Hattori, M., Minato, N., Kawaichi, M. and Honjo, T. J. Exp. Med. 170, 1103-1115 (1989) 

221. Unexpected biological effects of the deregulated IL-2/IL-2 receptor system on the lymphocyte development. Ishida, Y., Nishi, M., Taguchi, O., Inaba, K., Minato, N.,Kawaichi, M. and Honjo, T. Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation, Springer-Verlag Berlin Heidelberg 241-254 (1989) 

222. Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related. Noma, T., Nakakubo, H., Sugita, M., Kumagai, S., Maeda, M., Shimizu, A. and Honjo, T. J. Exp. Med. 169, 1853-1858 (1989) 

223. An interleukin 4-dependent precursor clone differentiates into myeloid cells as well as B lymphocytes. Kinashi, T., Tashiro, K., Inaba, K., Takeda, T., Palacios, R., Honjo, T. The First International Mochida Memorial Symposium 1988 -Recent Progress in Cytokine Research- 221-233 (1989) 

224. Close linkage of MEN2A with RBP3 locus in Japanese kindreds. Yamamoto, M., Takai, S., Miki, T., Motomura, K., Okazaki, M., Nishisho, I.,Tateishi, H., Miyauchi, A., Honjo, T., Pakstis, A. J. and Mori, T. Human Genet. 82, 287-288 (1989) 

225. T cells from eosinophilic patients produce interleukin-5 with interleukin-2 stimulation. Enokihara, H., Furusawa, S., Nakakubo, H., Kajitani, H., Nagashima, S., Saito, K., Shishido, H., Hitoshi, Y., Takatsu, K., Noma, T., Shimizu, A. and Honjo, T. Blood 73, 1809-1813 (1989) 

226. Immunological abnormalities in human interleukin-2 or interleukin-2/interleukin-2 receptor L chain transgenic mice. Ishida, Y., Nishi, M., Taguchi, O., Inaba, K., Minato, N., Kawaichi, M. and Honjo, T. Princess Takamatsu Symposia No. 19 “Immune System and Cancer” 61-71 (1989) 

227. Interleukin 5 enhances interleukin 2-mediated lymphokine-activated killer activity. Aoki, T., Kikuchi, H., Miyatake, S., Oda, Y., Iwasaki, K.,Yamasaki, T., Kinashi, T. and Honjo, T. J. Exp. Med. 170, 583-588 (1989) 

228. Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse. Shimizu, A., Nussenzweig, M. C., Mizuta, T-R, Leder, P. and Honjo, T. Proc. Natl. Acad. Sci. USA 86, 8020-8023 (1989) 

229. Molecular mechanism for immunoglobulin double-isotype expression. Shimizu, A., Kinashi, T., Nussenzweig, M. C., Mizuta, T-R., Leder, P. and Honjo, T. Cold Spring Harbor Symp. 175-181 (1989) 

230. Immune dysfunctions and activation of natural killer cells in human IL-2 and IL-2/IL-2 receptor L-chain transgenic mice. Ishida, Y., Nishi, M., Taguchi, O., Inaba, K., Minato, N., Kawaichi, M. and Honjo, T. Cold Spring Harbor Symp. 695-704 (1989) 

231. Preclinical detection in Japanese families with myotonic dystrophy using polymorphic DNA markers. Takemoto, Y., Miki, T., Nakura, J., Nishikawa, K., Kamino, K., Takeda, S., Kuze, K., Osame, M., Nakagawa, M., Higuchi, I., Yamada, T., Takayanagi, T., Matsubara, S., Saita, K., Takai, S., Honjo, T. and Ogihara T. Jpn. J. Human Genet. 34, 189-194 (1989) 

232. Structure and function of lymphokines and their receptors. Shimizu, A., Kinashi, T., Ishida, Y. and Honjo, T. International Congress of Immunology, Progress in Immunology VII 601-610 (1989) 

233. Purification and characterization of a protein that binds to the recombination signal sequence of the immunoglobulin JK segment. Hamaguchi, Y., Matsunami, N., Yamamoto, Y. and Honjo, T. Nucl. Acid. Res. 17, 9015-9026 (1989) 

234. A protein binding to the JK recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif. Matsunami, N., Hamaguchi, Y., Yamamoto, Y., Kuze, K., Kangawa, K., Matsuo, H., Kawaichi M. and Honjo, T. Nature 342, 934-937 (1989) 

235. Molecular mechanisms of lymphocyte differentiation. Honjo, T. Klinische Pharmakologie Clinical Pharmacology 1, Influence of Molecular Biology on Drug Discovery 5-9 (1989) 

236. Improvement in the antibody productivity of human-human hybridomas by transfection with Tac gene. Iwamoto, K., Shintani, Y., Sasada, R., Honjo, T. and Kitano, K. Cytotechnology 4, 29-37 (1990) 

237. Growth factors involved in lymphocyte differentiation. Kinashi, T.,Tashiro, K., Lee, K. H., Inaba, K., Toyama, K., Palacios R. and Honjo, T. Phil. Trans. R. Soc. Lond. 327, 117-125 (1990) 

238. Interleukin 5 and its receptor. Honjo, T. and Takatsu, K. Handbook of Experimental Pharmacology 95/I, 609-632 (1990) 

239. Molecular analysis of a chromosomal translocation, t(9;14)(p13;q32), in a diffuse large-cell lymphoma cell line expressing the Ki-1 antigen. Ohno, H., Furukawa, T., Fukuhara, S., Zong, S. Q., Kamesaki, H., Shows, T. B., Le Beau, M. M., McKeithan, T. W., Kawakami, T. and Honjo, T. Proc. Natl. Acad. Sci. USA 87, 628-632 (1990) 

240. Nucleotide sequences of the gene/cDNA coding for anti-murine erythrocyte autoantibody produced by a hybridoma from NZB mouse. Okamoto, M. and Honjo, T. Nucl. Acid. Res. 18, 1895 (1990) 

241. Differentiation of an interleukin 3-dependent precursor cell into myeloid cells as well as B lymphocytes. Kinashi, T., Tashiro, K., Lee, K. H., Inaba, K., Toyama, K., Palacios, R. and Honjo, T. International Conference on Molecular Aspects of Immune Response and Infectious Diseases, edited by H. Kiyono, E. Jirillo, and C. DeSimone. Raven Press, Ltd., 149-159 (1990) 

242. Immunoglobulin double isotype expression by trans-mRNA in a human m chain transgenic mouse. Shimizu, A., Nussenzweig, M. C., Mizuta, T-R., Leder, P. and Honjo, T. Recombinant systems in protein expression. edited by K. K. Alitalo, M.-L. Huhtala, J. Knowles, A. Vaheri. Int. Symp. in Finland, 101-110 (1990) 

243. The locus of Japanese myotonic dystrophy is also linked to D19S19 on the long arm of chromosome 19. Takemoto, Y., Miki, T., Nishikawa, K., Nakura, J., Kamino, K., Takai, S., Honjo, T. and Ogihara, T. Genomics 6, 195-196 (1990) 

244. Establishment of an interleukin-5-dependent subclone from an interleukin-3-dependent murine hemopoietic progenitor cell line, LyD9, and its malignant transformation by autocrine secretion of interleukin-5. Tohyama, K., Lee, K. H., Tashiro, K., Kinashi, T. and Honjo, T. EMBO J. 9, 1823-1830 (1990) 

245. Expression of murine IL-2 receptor b-chain on thymic and splenic lymphocyte subpopulations as revealed by the IL-2-induced proliferative respones in human IL-2 receptor a-chain transgenic mice. Hattori, M., Okazaki, H., Ishida, Y., Onuma, M., Kano, S., Honjo, T. and Minato, N. J. Immunol. 144, 3809-3815 (1990) 

246. Malignant transformation of an interleukin-5-dependent hemopoietic cell clone by autocrine secretion of lnterleukin-5. Tohyama, K., Lee, K. H., Tashiro, K., Kinashi, T. and Honjo, T. Acta Haematol. Jpn. 53, 1466-1472 (1990) 

247. Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments. Matsuda, F., Shin, E. K., Hirabayashi, Y., Nagaoka, H., Yoshida, M. C., Zong, S. Q. and Honjo, T. EMBO J. 9, 2501-2506 (1990) 

248. Circular DNA is excised by immunoglobulin class switch recombination. Iwasato, T., Shimizu, A., Honjo, T. and Yamagishi, H. Cell 62, 143-149 (1990) 

249. Oligoclonal immunoglobulin gene rearrangements in philadelphia chromosome-positive common acute lymphoblastic leukemia. Ikeda, T., Kita, K., Kawakami, K., Ohno, T., Seki, S., Nasu, K., Ueda, T., Honjo, T. and Shirakawa, S. Jpn. J. Cancer Res. 81, 340-344 (1990) 

250. Genetic heterogeneity in blast crisis of chronic myelocytic leukemia. Ikeda, T., Kita, K., Miwa, H., Kawakami, K., Anazawa, H., Ohno, T., Nosaka, T., Hatanaka, M., Honjo, T. and Shirakawa, S. Leukemia Research 14, 195-201 (1990) 

251. The cytoplasmic domain of the CD8 a-chain is required for its interaction with p56lck. Yao, L., Nakauchi, H., Honjo, T. and Kawakami, T. Immunol.Lett. 24, 267-272 (1990) 

252. HTLV-1 P27rex stabilizes human interleukin-2 receptor a chain mRNA. Kanamori, H., Suzuki, N., Siomi, H., Nosaka, T., Sato, A., Sabe, H., Hatanaka, M. and Honjo, T. EMBO J. 9, 4161-4166 (1990) 

253. Control of IL-2 receptor-a expression by IL-1, tumor necrosis factor, and IL-2: complex regulation via elements in the 5′ flanking region. Plaetinck, G., Combe, M.-C., Corthesy, P., Sperisen, P., Kanamori, H., Honjo, T. and Nabholz, M. J. Immunol. 145, 3340-3347 (1990) 

254. Deletion of human JK segments by site-specific recombination recognizing the conserved nonamer and heptamer sequences. Nakatani, T., Horigome, K., Nomura, N., Kondo, T., Ohtsuka, H., Noguchi, H. and Honjo, T. Nucl. Acid. Res. 18, 5529-5532 (1990) 

255. Stepwise formation of the high-affinity complex of the interleukin 2 receptor. Saito, Y., Ogura, T., Kamio, M., Sabe, H., Uchiyama, T. and Honjo, T. Int. Immunol. 2, 1167-1177 (1990) 

256. Efficient transient expression of cDNA in CTLL-2 cells expressing polyoma large T-antigen. Koromilas, A. E., Sabe, H., Saito, Y., Kondo, S. and Honjo, T. Technique 2, 189-193 (1990) 

257. Why are multiple chains required for the interleukin 2 receptor? Saito, Y. and Honjo, T. Growth Factor Res. 2, 207-222 (1990) 

1991-1996

258. Cloning and characterization of a protein binding to the Jk recombination signal sequence of immunoglobulin genes. Hamaguchi, Y., Matsunami, N., Yamamoto, Y., Kuze, K., Kangawa, K., Matsuo, H., Kawaichi, M. and Honjo, T. Mechanisms of Lymphocyte Activation and Immune Regulation III, Edited by S. Gupta et al., Plenum Press, New York (1991) 

259. Different stromal cell lines support lineage-selective differentiation of the multipotential bone marrow stem cell clone LyD9. Lee, K. H., Kinashi, T., Tohyama, K., Tashiro, K., Funato, N., Hama, K. and Honjo, T. J. Exp. Med. 173, 1257-1266 (1991) 

260. Premature expression of the macrophage colony stimulating factor receptor on a multipotential stem cell line does not alter defferentiation lineage specificity determined by stromal cells used for coculture. Kinashi, T., Lee, K. H., Ogawa, M., Tohyama, K., Tashiro, K., Fukunaga, R., Nagata, S., and Honjo, T. J. Exp. Med. 173, 1267-1279 (1991) 

261. Germline transcripts of the immunoglobulin heavy-chain and T cell receptor genes in a murine hematopoietic stem cell line LyD9 and its derivative cell lines. Tashiro, K., Kinashi, T., Anderson, S. J., Lee, K. H., Tohyama, K., Ogawa, M., Takahashi, M., Kawaichi, M. and Honjo, T. Immunol. lett. 28, 147-154 (1991) 

262. Genomic organization of IgH gene compared the expression of Bcl-2 gene in t(14;18)-Positive lymphoma. Amakawa, R., Fukuhara, S., Ohno, H., Tanabe, S., Matsuyama, H., Okuma, M., Sideras, P., Mizuta, T. R. and Honjo, T. Blood 77, 1970-1976 (1991) 

263. Characterization of the promoter/enhancer region for germline transcription of the gamma 3 constant region gene of the human immunoglobulin. Kuze, K., Shimizu, A. and Honjo, T. Int. Immunol. 3, 647-655(1991) 

264. Trans-splicing as a possible molecular mechanism for the multiple isotype expression of the immunoglobulin gene. Shimizu, A., Nussenzweig, M. C., Han, H., Sanchez, M. and Honjo, T. J. Exp. Med. 174, 1385-1393 (1991) 

265. Duplicated variable region genes account for double-isotype expression in a human leukemic B cell line that gives rise to single isotype-expressing cells. Mizuta, T.-R., Suzuki, N., Shimizu, A. and Honjo, T. J. Biol. Chem. 266, 12514-12521 (1991) 

266. Differentiation of a human eosinophilic leukemia cell line (EoL-1) by a human T cell leukemia cell line (HIL-3)-derived factor. Morita, M., Saito, H., Honjo, T., Saito, Y., Tsuruta, S., Kim, K-M., Tanaka, M., Mori, K. J., Mayumi, M. and Mikawa, H. Blood 177, 1766-1775 (1991) 

267. The nucleolar localisation signal of the HTLV-1 protein p27rex is important for stabilisation of IL-2 receptor. White, K. N., Nosaka, T., Kanamori, H., Hatanaka, M., and Honjo, T. Biochem. Biophys. Res. Commun. 175, 98-103 (1991) 

268. Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin. Era, T., Ogawa, M., Nishikawa, S., Okamoto, M., Honjo, T., Akagi, K., Miyazaki, J. and Yamamura, K. EMBO J. 10, 337-342 (1991) 

269. The membrane exons of the pseudo-g-chain gene of the human immunoglobulin are apparently functional and highly homologous to those of the g1 gene. Kinoshita, K., Shimizu, A. and Honjo, T. Immunol. Lett. 27, 151-156 (1991) 

270. Shared partners in receptors. Honjo, T. Current Biology 1, 201-203 (1991) 
271. The Drosophila RBP-Jk gene encodes the binding protein for the immunoglobulin Jk recombination signal sequence. Furukawa, T., Kawaichi, M., Matsunami, N., Ryo, H., Nishida, Y., and Honjo, T. J. Biol. Chem. 266, 23334-23340 (1991) 

272. Recombination of exogenous interleukin 2 receptor gene flanked by immunoglobulin recombination signal sequences in a Pre-B cell line and transgenic mice. Kawaichi, M., Oka, C., Reeves, R., Kinoshita, M. and Honjo, T. J. Biol. Chem. 266, 18387-18394 (1991) 

273. Comparison of protein tyrosine phosphorylation and morphological changes induced by IL-2 and IL-3. Sabe, H., Kuno, J., Koromilas, A., Saito, Y., Kinashi, T., Ueda, M., Takamatsu, T., Hamaguchi, M., Kawakami, T. and Honjo, T. Int. Immunol. 3, 1137-1148 (1991) 

274. Biochemical evidence for a third chain of the interleukin-2 receptor. Saito, Y., Tada, H., Sabe, H. and Honjo, T. J. Biol. Chem. 266, 22186-22191 (1991) 

275. Physical map of the 3′ region of the human immunoglobulin heavy chain locus:clustering of autoantibody-related variable segments in one haplotype. Shin, E. K., Matsuda, F., Nagaoka, H., Fukita, Y., Imai, T., Yokoyama, K., Soeda, E. and Honjo, T. EMBO J. 10, 3641-3645(1991) 

276. Regulated expression of immunoglobulin trans-mRNA consisting of the variable region of transgenic m chain and constant regions of endogenous isotypes. Han, H., Okamoto, M., Honjo, T. and Shimizu, A. Int. Immunol. 3, 1197-1206 (1991) 

277. Expression of the RAG-2 gene in murine central nervous system tumor cell lines. Aoki, T., Tashiro, K., Miyatake, S., Nakano, T., Oda, Y., Kikuchi, H. and Honjo, T. Biochem. Biophys. Res. Commun. 181, 151-158 (1991) 

278. A transgenic model of autoimmune hemolytic anemia. Okamoto, M., Murakami, M., Shimizu, A., Ozaki, S., Tsubata, T., Kumagai, S. and Honjo, T. J. Exp. Med. 175, 71-79 (1992) 

279. Genomic organization of mouse Jk recombination signal binding protein(RBP-Jk) gene. Kawaichi, M., Oka, C., Shibayama, S., Koromilas, A. E., Matsunami, N., Hamaguchi, Y. and Honjo, T. J. Biol. Chem. 267, 4016-4022 (1992) 

280. Mapping of the nu gene using congenic nude strains and in situ hybridization. Takahashi, Y., Shimizu, A., Sakai, T., Endo, Y., Osawa, N., Shisa, H. and Honjo, T. J. Exp. Med. 175, 873-876 (1992) 

281. Rearrangement patterns of immunoglobulin heavy chain (IgH) and light chain genes in acute lymphoblastic leukemia and chronic myelocytic leukemia lymphoid crisis cells showing oligoclonal IgH gene rearrangements. Kawakami, K., Kita, K., Miwa, H., Ikeda, T., Nishii, K., Masuya, M., Morita, N., Ohno, T., Tanaka, I., Nosaka, T., Honjo, T. and Shirakawa, S. Int. J. of Hematol. 55, 61-69 (1992) 

282. Expression of murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicity in vivo. Aoki, T., Tashiro, K., Miyatake, S., Kinashi, T., Nakano, T., Oda,Y., Kikuchi, H. and Honjo, T. Proc. Natl. Acad. Sci. USA 89, 3850-3854 (1992) 

283. Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice. Murakami, M., Tsubata, T., Okamoto, M., Shimizu, A., Kumagai, S., Imura, H. and Honjo, T. Nature 357, 77-80 (1992) 

284. Biased distribution of recombination sites within S regions upon immunoglobulin class switch recombination induced by TGFb and lipopolysaccharide. Iwasato, T., Arakawa, H., Shimizu, A., Honjo, T. and Yamagishi, H. J. Exp. Med. 175, 1539-1546 (1992) 

285. Biochemical and immunological characterization of the DNA binding protein (RBP-Jk) to mouse Jk recombination signal sequence. Hamaguchi, Y., Yamamoto, Y., Iwanari, H., Maruyama, S., Furukawa, T,. Matsunami, N. and Honjo, T. J. Biochem. 112, 314-320 (1992) 

286. The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development. Furukawa, T., Maruyama, S., Kawaichi, M., and Honjo, T. Cell 69, 1191-1197 (1992) 

287. Regulation of blood cell differentiation. Kinashi, T., Lee, K. H., Tohyama, K., Tashiro, K., and Honjo, T. Conference on Molecular Biology of the Myocardium 63-73 (1992) 

288. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. Ishida, Y., Agata, Y., Shibahara, K., and Honjo, T. EMBO J. 11, 3887-3895 (1992) 

289. Seppuku and autoimmunity. Honjo, T. Science 258, 591-592 (1992) 

290. Synergy of interleukin 5 with interleukin 2 in the generation of lymphokine-activated killer cells. Aoki, T., Kikuchi, H., Miyatake, S., Oda, Y., Otsuka, S., Kinashi, T. and Honjo, T. Int. J. Oncology 1, 165-174 (1992) 

291. Maturational stage specific immunoglobulin heavy chain gene rearrangements, determined by D and D upstream region gene structures. Miwa, H., Kita, K., Nasaka, T., Ikeda, T., Kawakami, K., Anazawa, H., Hoshino, K., Ohno, T., Honjo, T., Hatanaka, M. and Shirakawa, S. Leukemia Research 16, 861-871 (1992) 

292. Interleukin 2 and tumor necrosis factor a are complementary for proliferation of the hematopoietic stem cell line LyD9. Saito, Y., Tada, H., Nazarea, M., and Honjo, T. Growth Factors 7, 297-303 (1992) 

293. Organization of the human immunoglobulin heavy-chain locus. Matsuda, F., Shin, E. K., Nagaoka, H., Matsumura, R., Haino, M., Fukita, Y., Takaishi, S., Imai, T., Riely, J. H., Anand, R., Soeda, E. and Honjo, T. Progress in Immunology VIII, 91-97, (Proceedings of the 8th International Congress of Immunology Budapest 1992) 

294. Diversification, not use, of the immunoglobulin VH gene repertoire is restricted in digeorge syndrome. Haire, R. N., Buell, R.D., Litman, R. T., Ohta, Y., Fu, S.M., Honjo, T., Matsuda, F., de la Morena, M., Carro, J., Good, R.A. and Litman, G.W. J. Exp. Med. 178, 825-834 (1993) 

295. Structure and physical map of 64 variable segments in the 3′ 0.8-megabase region of the human immunoglobulin heavy-chain locus. Matsuda, F., Shin, E. K., Nagaoka, H., Matsumura, R., Haino, M., Fukita, Y., Takaishi, S., Imai, T., Riley, J. H., Anand, R., Soeda, E. and Honjo, T. Nature Genet. 3, 88-94 (1993) 

296. Synthesis and regulation of trans-mRNA encoding immunoglobulin and heavy chain. Shimizu, A. and Honjo, T. The FASEB J. 7, 149-154 (1993) 

297. The complete murine immunoglobulin class switch region of the a heavy chain gene-hierarchic repetitive structure and recombination breakpoints. Arakawa, H., Iwasato, T., Hayashida, H., Shimizu, A., Honjo, T. and Yamagishi, G. J. Biol. Chem. 268, 4651-4655 (1993) 

298. Isolation of cDNA encoding a binding protein specific to 5′-phosphorylated sigle-stranded DNA with G-rich sequences. Mizuta, T-R., Fukita, Y., Miyoshi, T., Shimizu, A. and Honjo, T. Nucl. Acid. Res. 21, 1761-1766 (1993) 

299. A monoclonal antibody which inhibits growth of T cell lines. Nazarea, M., Saito, Y., Okazaki, S., Suzuki, N. and Honjo, T. Growth Factors 9, 139-147 (1993) 

300. Polymorphism of the human immunoglobulin variable region segment V1-4.1. Shin, E. K., Matsuda, F., Ozaki, S., Kumagai, S., Olerup, O., Str嗄, H., Melchers, I. and Honjo, T. Immunogenetics 38, 304-306 (1993) 

301. B cell apoptosis induced by antigen receptor crosslinking is blocked by T cell signal through CD40. Tsubata, T., Wu, J. and Honjo, T. Nature 364, 645-648 (1993) 

302. The human Smbp-2, a DNA binding protein specific to the single-stranded guanine-rich sequence related to the immunoglobulin m chain switch region. Fukita, Y., Mizuta, T-R., Shirozu, M., Ozawa, K., Shimizu, A. and Honjo, T. J. Biol. Chem. 268, 17463-17470 (1993) 

303. SL/KH strain of mice: a model of spontaneous pre-B-lymphomas. Shimada, M., Yamada, Y., Nakakuki, Y., Okamoto, K., Fukumoto, M., Honjo, T. and Hiai, H. Leukemia Research 17, 573-578 (1993) 

304. Human Jk recombination signal binding protein (IGKJRB) gene: comparison with its mouse homologue. Amakawa, R., Wu, J., Ozawa, K., Matsunami, N., Hamaguchi, Y., Matsuda, F., Kawaichi, M. and Honjo, T. Genomics 17, 306-315(1993) 

305. Signal sequence trap: cloning strategy for secreted proteins and type I membrane proteins. Tashiro, K., Tada, H., Heilker, R., Shirozu, M., Nakano, T. and Honjo, T. Science 261, 600-603 (1993) 

306. Pseudo-high affinity interleukin 2 receptor and growth signal transduction in lymphocytes. Saito, Y., Nazarea, M. and Honjo, T. Int. Immunol. 5, 1211-1217(1993) 

307. The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow. Nisitani, S., Tsubata, T., Murakami, M., Okamoto, M. and Honjo, T. J. Exp. Med. 178, 1247-1254 (1993) 

308. Cloning of a human immunoglobulin gene fragment containing both VH-D andD-JH rearrangements: implication for VH-D as an intermediate to VH-D-JH formation. Shin, E. K., Akamizu, T., Matsuda, F., Sugawa, H., Fujikura J., Mori, T. and Honjo, T. Eur. J. Immunol. 23, 2365-2367 (1993) 

309. Physical mapping of variable region gene locus of human immunoglobulin heavy chain. Matsuda, F. and Honjo, T. Methods in Mol. Genet. 2, 226-245 (1993) 

309a. Ly-1 B cells as a component of gut associated lymphoid tissues for mucosal immunity. Murakami, M., Tsubata, T., and Honjo, T Current topics in Mucosal Immunology 1993 (Proceedings of the Tokyo International Symposium on Mucosal Immunology, Keidanren Kaikan, 25-27, August, 1993) Excerpta Medica (eds. Tsuchiya, M., Yodoi, J., Hibi, T. and Miura, S.) 139-142 (1993) 

310. Antigen-receptor cross-linking induces peritoneal B cell apoptosis in normal but not autoimmunity-prone mice. Tsubata, T., Murakami, M. and Honjo, T. Current Biology 4, 8-17(1994) 

311. Structural analysis of the human VH locus using non-repetitive intergenic probes and repetitive sequence probes: Evidence for recent reshuffling. Matsumura, R., Matusda, F., Nagaoka, H., Fujikura, J., Shin, E. K., Fukita, Y., Haino, M. and Honjo, T. J. Immunol. 152, 660-666 (1994) 

312. Comparison and evolution of human immunoglobulin VH segments located in the 3’0.8-megabase region. Haino, M., Hayashida, H., Miyata, T., Shin, E. K., Matsuda, F., Nagaoka, H., Matsumura, R., Takaishi, S., Fukita, Y., Fujikura, J. and Honjo, T. J. Biol. Chem. 269, 2619-2626 (1994) 

313. Variable-Regions of immunoglobulin heavy-chain genes encoding anti-thyrotropin (TSH) receptor antibodies of patients with graves’ disease. Shin, E. K., Akamizu, T., Matsuda, F., Sugawa, H., Fujikura, J., Mori, T. and Honjo, T. J. Immunol. 152, 1485-1492 (1994) 

314. Recoginition sequence of a highly conserved DNA binding protein RBP-Jk. Tin Tun, Hamaguchi, Y., Matsunami, N., Furukawa, T., Honjo, T. and Kawaichi M. Nuc. Acid. Res. 22, 965-971 (1994) 

315. The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor. Dou S., Zeng, X., Cortes, P., Erdjument-Bromage, H., Tempst,P., Honjo, T. and Vales, L.D. Molecular and Cellular Biol. 14, 3310-3319 (1994) 

316. Lineage marker-negative lymphocyte precursors derived from embryonic stem cells in vitro differentiate into mature lymphocytes in vivo. Nisitani, S., Tsubata, T. and Honjo, T. Int. Immunol. 6, 909-916(1994) 

317. Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse. Murakami, M., Tsubata, T., Shinkura, R., Nisitani, S., Okamoto, M., Yoshioka, H., Usui, T., Miyawaki, S. and Honjo, T. J. Exp. Med. 180, 111-121 (1994) 

318. Site-directed mutagenesis study on DNA binding regions of the mouse homologue of Suppressor of Hairless, RBP-Jk. Chung, C., Hamaguchi, Y., Honjo, T. and Kawaichi, M. Nucl. Acid. Res. 22, 2938-2944 (1994) 

319. Generation of lymphohematopoietic cells from embryonic stem cells in culture. Nakano, T., Kodama, H. and Honjo, T. Science 265, 1098-1101 (1994) 

320. Recent translocation of variable and diversity segments of the human immunoglobulin heavy chain from chromosome 14 to chromosomes 15 and 16. Nagaoka, H., Ozawa K., Matsuda, F., Hayashida, H., Matsumura, R., Haino, M., Shin, E.K., Fukita, Y., Imai, T., Anand, R., Yokoyama, K., Eki, T., Soeda, E. and Honjo, T. Genomics 22, 189-197 (1994) 

321. Molecular mechanisms for B lymphocyte selection: induction and regulation of antigen-receptor-mediated apoptosis of mature B cells in normal mice and their defect in autoimmunity-prone mice. Tsubata, T., Murakami, M., Nisitani, S. and Honjo, T. Philosophical Transactions of the Royal Society of London series B 345, 297-301 (1994) 

322. Transforming growth factor-b induced class switch recombination may be modified during the cell proliferation restored by IL-2 stimulation. Iwasato, T., Kanari, Y., Shimizu, A., Honjo, T and Yamagishi, H. Immunol. Lett. 39, 173-178 (1994) 

323. Structure and chromosomal localization of the human PD-1 gene. Shinohara, T., Taniwaki, M., Ishida, Y., Kawaichi, M. and Honjo, T. Genomics 23, 704-706 (1994) 

324. Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-Jk, the homologue of Drosophila Suppressor of Hairless. Zimber-Strobl, U., Strobl, L. J., Meitinger, C., Hinrichs,R.,Sakai, T., Furukawa, T., Honjo, T. and Bornkamm. G.W. EMBO. J. 13, 4973-4982 (1994) 

325. Heterogeneity and diversity of IgM and IgG lupus anticoagulants in an individual with systemic lupus erythematosus. Nakamura, N., Azuma, C., Akamizu, T., Sugawa, H., Matsuda, F., Mitsuda, N., Honjo, T., Mori, T. and Yamaji, K. Biochemical and Biophysical Research Communications 203, 1789-1794 (1994)

326. Interleukin-2 can support growth of CD8+ T cells but not CD4+ T cells of human IL-2 receptor b chain transgenic mice. Asano, M., Ishida, Y., Sabe, H., Kondo, M., Sugamura, K. and Honjo, T. J. Immunol. 153, 5373-5381 (1994) 

327. Genetic characterization of Drosophila RBP-Jk (suppressor of hairless)as a neurogenic gene in adult PNS development. Furukawa, T., Kimura, K., Kobayakawa, Y., Tamura, K., Kawaichi, M., Tanimura, T. and Honjo, T. Jpn. J. Genet. 69, 701-711 (1994) 

328. B-1 cells as a component of gut associated lymphoid tissues for mucosal immunity. Murakami, M., Tsubata, T., Shinkura, R., Usui, T., Yoshioka, H., Miyawaki, S. and Honjo, T. Recent Advances in Gastrenterology (ed. Yoshida, Y. and Murata, Y.), Churchil Livingstone, Current Advances in Digestive Disease 1, 75-86 (1994) 

329. Prevention of autoimmune symptoms in autoimmune-prone mice by elimination of B-1 cells. Murakami, M., Yoshioka, H., Shirai, T., Tsubata, T. and Honjo, T. Int. Immunol. 7, 877-882 (1995) 

330. Suppressor of hairless, the Drosophila homologue of RBP-Jk, transactivates the neurogenic gene E(spl)m8. Furukawa, T., Kobayakawa, Y., Tamura, K., Kimura, K., Kawaichi, M., Tanimura, T. and Honjo, T. Jpn. J. Genet. 70, 505-524 (1995) 

331. Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. Shirozu, M., Nakano, T., Inazawa, J., Tashiro, K., Tada, H., Shinohara, T. and Honjo, T. Genomics 28 495-500 (1995) 

332. Loss of immunostaining of the RBP-Jk transcription factor upon F9 cell differentiation induced by retinotic acid. Sakai, T., Furukawa, T., Iwanari, H., Oka, C., Nakano, T., Kawaichi, M. and Honjo, T. J. Biochem. 118 621-628 (1995) 

333. Immunoglobulin heavy chain loci of mouse and human. Honjo, T. and Matsuda, F. Immunoglobulin Genes 2nd Edition, Academic Press Limited, (edited by T. Honjo, T W. Alt and T H. Rabbitts.) 145-171 (1995) 

334. Regulation of class switch recombination of the immunoglobulin heavy chain genes. Zhang, J., Alt, F.W. and Honjo, T. Immunoglobulin Genes 2nd Edition, Academic Press Limited, (edited by T. Honjo, T W. Alt andT H. Rabbitts.) 235-266 (1995) 

335. Disruption of the mouse RBP-Jk gene results in early embryonic death. Oka, C., Nakano, T., Wakeham, A., Pompa, J.L., Mori, C., Sakai, T., Okazaki, S., Kawaichi, M., Shiota, K., Mak, T. and Honjo T. Development 121 3291-3301 (1995) 

336. Involvement of B-1 cells in mucosal immunity and autoimmunity. Murakami, M. and Honjo, T. Immunology Today 16 534-539 (1995) 

337. B-1 cells and autoimmunity. Murakami, M. and Honjo, T. Immunoglobulin Gene Expression in Development and Disease. Annals of the New York Academy of Sciences 764 402-409 (1995) 

338. Physical interaction between a novel domain of the receptor notch and the transcription factor RBP-Jk/Su(H). Tamura, K., Taniguchi, Y., Minoguchi, S., Sakai, T., Tin Tun, Furukawa, T. and Honjo, T. Curr. Biol. 5 1416-1423 (1995) 

339. The murine lymphotoxin-b receptor cDNA;isolation by the signal sequence trap and chromosomal mapping. Nakamura, T., Tashiro, K., Nazarea,.M., Nakano, T., Sasayama, S. and Honjo T. Genomics 30 312-319 (1995) 

340. Administration of interleukin-5 or -10 activates peritoneal B-1 cells and induces autoimmune hemolytic anemia in anti-erythrocyte autoantibody-transgenic mice. Nisitani, S., Tsubata, T., Murakami, M and Honjo, T. Eur. J. Immunol. 25 3047-3052 (1995) 

341. Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death. Shibahara, K., Asano, M., Ishida, Y., Aoki, T., Koike, T. and Honjo, T. Gene 166 297-301 (1995) 

1996-2000

342. Anti-red blood cell autoantibody transgenic mice: murine model of antoimmune hemolytic anemia. Murakami, M. and Honjo, T. Semin. Immunol. 8 3-9 (1996) 

343. High frequency class switching of an IgM+ B lymphoma clone CH12F3 to IgA+ cells. Nakamura, M., Kondo, S., Sugai, M., Nazarea, M., Imamura, S. and Honjo, T. Int. Immunol. 8 193-201 (1996) 

344. The shortest path from the surface to the nucleus: RBP-Jk/Su(H) transcription factor. Honjo, T. Genes Cells 1 1-9 (1996) 

345. Development of blood cells from mouse embryonic stem cells in culture. Nakano, T., Era, T., Kodama, H. and Honjo, T. Bone Marrow Transplantation. Basic and Clinical Studies (ed. by Ikehara, S., Takaku, F. and Good, R.A.), Springer-Verlag, Tokyo. 9-19 (1996) 

346. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Agata, Y., Kawasaki, A., Nishimura, H., Ishida, Y., Tsubata, T., Yagita, H. and Honjo, T. Int. Immunol. 8 765-772 (1996)

347. Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes. Nishimura, H., Agata, Y., Kawasaki, A., Sato, M., Imamura, S., Minato, N., Yagita, H., Nakano, T. and Honjo, T. Int. Immunol. 8 773-780 (1996) 

348. In vitro development of primitive and definitive erythrocytes from different precursors. Nakano, T., Kodama, H. and Honjo, T. Science 272 722-724 (1996) 

349. Signal sequence trap. Tashiro, K., Nakano, T. and Honjo, T. Methods in Molecular Biology (ed. by Cowell, I. G. and Austin, C. A.), Human a Press Inc., NJ. 69 203-219 (1996) 

350. Epidermal growth factor can replace thymic mesenchyme in induction of embryonic thymus morphogenesis in vitro. Shinohara, T. and Honjo, T. Eur. J. Immunol. 26 747-752 (1996) 

351. Antigen receptor-mediated B cell death is blocked by signaling via CD72 or treatment with dextran sulfate and is defective in autoimmunity-prone mice. Nomura, T., Han, H., Howard, M.C., Yagita, H., Yakura, H., Honjo, T. and Tsubata, T. Int. Immunol. 8 867-875 (1996) 

352. Rescue of the hairless phenotype in nude mice by transgenic insertion of the wild-type Hfh11 genomic locus. Kurooka, H., Segre, J. A., Hirano, Y., Nemhauser, J. L., Nishimura, H., Yoneda, K., Lander, E. S. and Honjo, T. Int. Immunol. 8 961-966 (1996) 

353. Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice. Shinkura, R., Matsuda, F., Sakiyama, T., Tsubata, T., Hiai, H.,Paumen, M., Miyawaki, S. and Honjo, T. Int. Immunol. 8 1067-1075(1996) 

354. Organization of the human immunoglobulin heavy-chain locus. Matsuda, F. and Honjo, T. Advances in Immunology (ed. by F.J. Dixon), Academic Press, Inc. 62 1-29 (1996) 

355. Functional conservation of mouse Notch receptor family members. Kato, H., Sakai, T., Tamura, K., Minoguchi, S., Shirayoshi, Y., Hamada, Y., Tsujimoto, Y. and Honjo, T. FEBS Lett. 395 221-224(1996) 

356. Isolation and characterization of a novel secretory protein, stromal cell-derived factor-2 (SDF-2) using the signal sequence trap method. Hamada, T., Tashiro, K., Tada, H., Inazawa, J., Shirozu, M.,Shibahara, K., Nakamura, T., Martina, N., Nakano, T. and Honjo, T. Gene 176 211-214 (1996) 

357. Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. Shirozu, M., Tada, H., Tashiro, K., Nakamura, T., Lopez, N. D.,Nazarea, M., Hamada, T., Sato, T., Nakano, T. and Honjo, T. Genomics 37 273-280 (1996) 

358. Autoimmune disease of exocrine organs in immunodeficient alymphoplasia mice: a spontaneous model for Sj喩ren’s syndrome. Tsubata, R., Tsubata, T., Hiai, H., Shinkura, R., Matsumura, R., Sumida, T., Miyawaki, S., Ishida, H., Kumagai, S., Nakao, K., and Honjo, T. Eur. J. Immunol. 26 2742-2748 (1996) 

359. Differential modulation of cyclin-dependent kinase inhibitor p27kip1 by negative signaling via the antigen receptor of B cells and positive signaling via CD40. Han, H., Nomura, T., Honjo, T. and Tsubata, T. Eur. J. Immunol. 26 2425-2432 (1996) 

359a. Molecular analysis of stimulatory anti-thyrotropin receptor antibodies(TSAbs) involved in Graves’ disease: Isolation and reconstruction of antibody genes, and production of monoclonal TSAbs. Akamizu, T., Matsuda, F., Okuda, J., Li, H., Kanda, H., Watanabe, T., Honjo, T. and Mori, T. J. Immunol. 157 3148-3152 (1996) 

360. Induction of bip mRNA upon programmed cell death of differentiated PC12 cells as well as rat sympathetic neurons1. Aoki, T., Koike, T., Nakano, T., Shibahara, K., Kondo, S., Kikuchi, H. and Honjo, T. J. Biochem. 121 122-127 (1997) 

361. Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. Paumen, M. B., Ishida, Y., Muramatsu, M., Yamamoto, M. and Honjo, T. J. Biol. Chem. 272 3324-3329 (1997) 

362. Studies in vitro on the mechanism of the epithelial/mesenchymal interaction in the early fetal thymus. Shinohara, T. and Honjo, T. Eur. J. Immunol. 27 522-529 (1997) 

363. Cloning and characterization of the nucleoredoxin gene that encodes a novel nuclear protein related to thioredoxin. Kurooka, H., Kato, K., Minoguchi, S., Takahashi, Y., Ikeda, J., Habu, S., Osawa, N., Buchberg, A. M., Moriwaki, K., Shisa, H. and Honjo, T. Genomics 39 331-339 (1997) 

364. Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase I with Bcl-2. Paumen, M. B., Ishida, Y., Han, H., Muramatsu, M., Eguchi, Y., Tsujimoto, Y. and Honjo, T. Biochem. Biophys. Res. Commun. 231 523-525 (1997) 

365. RBP-L, a transcription factor related to RBP-Jk. Minoguchi, S., Taniguchi, Y., Kato, H., Okazaki, T., Strobl., L. J., Zimber-Strobl, U., Bornkamm, G.W. and Honjo, T. Mol. Cell. Biol. 17 2679-2687 (1997) 

366. Conservation of the Notch signalling pathway in mammalian neurogenesis. de la Pompa, J. L., Wakeham, A., Correia, K. M., Samper, E., Brown, S., Aguilera, R. J., Nakano, T., Honjo, T., Mak, T. W., Rossant, J. and Conlon, R. A. Development 124 1139-1148 (1997) 

367. Effects of breeding environments on generation and activation of autoreactive B-1 cells in anti-red blood cell autoantibody transgenic mice. Murakami, M., Nakajima, K., Yamazaki, K., Muraguchi, T., Serikawa, T. and Honjo, T. J. Exp. Med. 185 791-794 (1997) 

368. Anti-red blood cell immunoglobulin transgenic mice; An experimental model of autoimmune hemolytic anemia. Nisitani, S., Murakami, M. and Honjo, T. Ann. NY Acad. Sci. 815 246-252 (1997) 

369. Rat TAFII31 gene is induced upon programmed cell death in differentiated PC12 cells deprived of NGF1. Aoki, T., Koike, T., Nakano, T., Shibahara, K., Nishimura, H., Kikuchi, H. and Honjo, T. Biochem. Biophys. Res. Commun. 234 230-234 (1997) 

370. Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF. Yabe, D., Nakamura, T., Kanazawa, N., Tashiro, K. and Honjo, T. J. Biol. Chem. 272 18232-18239 (1997) 

371. Development of erythroid cells from mouse embryonic stem cells in culture: potential use for erythroid transcription factor study. Nakano, T., Era, T., Takahashi, T., Kodama, H. and Honjo, T. Leukemia 11 496-500 (1997) 

372. Involvement of RBP-J in biological functions of mouse Notch 1 and its derivatives. Kato, H., Taniguchi, Y., Kurooka, H., Minoguchi,S., Sakai, T., Nomura-Okazaki, S., Tamura, K. and Honjo, T. Development 124 4133-4141 (1997) 

373. Preferential localization of human CD5+ B cells in the peritoneal cavity. Nisitani, S., Murakami, M., Akamizu, T., Okino, T., Ohmori, K., Mori, T., Imamura, M. and Honjo, T. Scand. J. Immunol. 46 541-545 (1997) 

374. Transgenic mouse models for B-cell dominant autoimmune diseases. Murakami, M. and Honjo, T. Curr. Opin. Immunol. 9 846-850 (1997) 

375. Structure of the mutant fibrillin-1 gene in the tight skin (TSK) Mouse. Bona, C. A., Murai, C., Casares, S., Kasturi, K., Nishimura, H., Honjo, T. and Matsuda, F. DNA Res. 4 267-271 (1997) 

375a. Evidence for regulation of transcription and replication of the human neurotropic virus JCV genome by the human Smbp-2 protein in glial cells. Chen, N. N., Kerr, D., Chang, C-F., Honjo, T. and Khalili, K. Gene 185 55-62 (1997) 

376. LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein. Taniguchi, Y., Furukawa, T., Tun, T., Han, H. and Honjo, T. Mol. Cell. Biol. 18 644-654 (1998) 

377. Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. Winkler, C., Modi, W., Smith, M.W., Nelson, G. W., Wu, X., Carrington, M., Dean, M., Honjo, T., Tashiro, K., Yabe, D., Buchbinder, S., Vittinghoff, E., Goedert, J. J., O’Brien, T. R., Jacobson, L. P., Detels, R., Donfield, S., Willoughby, A., Gomperts, E., Vlahov, D., Phair, J., ALIVE Study, HGDS, MACS, MHCS, SFCC, and O’Brien, S. J. Science 279 389-393 (1998) 

378. Frequent but biased class switch recombination in the Sm flanking regions. Lee, C.-G., Kondo, S. and Honjo, T. Curr. Biol. 8 227-230 (1998) 

379. Isolation of differentially expressed genes upon immunoglobulin class switching by a subtractive hybridization method using uracil DNA glycosylase. Sugai, M., Kondo, S., Shimizu., A. and Honjo, T. Nucleic Acids Res. 26 911-918 (1998) 

380. Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32. Yabe, D., Taniwaki, M., Nakamura, T., Kanazawa, N., Tashiro, K. and Honjo, T. Genomics 49 331-333 (1998) 

381. Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1a (SDF-1a) and SDF-1b are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage. Shioda, T., Kato, H., Ohnishi, Y., Tashiro, K., Ikegawa, M., Nakayama, E. E., Hu, H., Kato, A., Sakai, Y., Liu, H., Honjo, T., Nomoto, A., Iwamoto, A., Morimoto, C. and Nagai, Y. Proc. Natl. Acad. Sci. USA 95 6331-6336 (1998) 

382. Functional replacement of the intracellular region of the Notch1 receptor by Epstein-Barr Virus Nuclear Antigen 2. Sakai, T., Taniguchi, Y., Tamura, K., Minoguchi, S., Fukuhara, T., Strobl, L. J., Zimber-Strobl, U., Bornkamm, G. W. and Honjo, T. J. Virol. 72 6034-6039 (1998) 

383. Antigen receptor cross-linking by anti-immunoglobulin antibodies coupled to cell surface membrane induces rapid apoptosis of normal spleen B cells. Watanabe, N., Nomura, T., Takai, T.,Chiba, T., Honjo, T. and Tsubata, T. Scand. J. Immunol. 47 541-547 (1998) 

384. Large quantity production with extreme convenience of human SDF-1a and SDF-1b by a Sendai virus vector. Moriya, C., Shioda, T., Tashiro, K., Nagasawa, T., Ikegawa, M., Ohnishi, Y., Kato, A., Hu, H., Xin, X., Hasan, M. K., Maekawa, M., Takabe, Y., Sakai, Y., Honjo, T. and Nagai, Y. FEBS Lett. 425 105-111 (1998) 

385. Involvement of IL-10 in induction of autoimmune hemolytic anemia in anti-erythrocyte Ig transgenic mice. Nisitani, S., Sakiyama, T. and Honjo, T. Int. Immunol. 10 1039-1047 (1998) 

386. Immunological studies on PD-1-deficient mice: implication of PD-1 as a negative regulator for B cell responses. Nishimura, H., Minato, N., Nakano, T. and Honjo, T. Int. Immunol. 10 1563-1572 (1998) 

387. Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability. Nakamura, T., Yabe, D., Kanazawa, N., Tashiro, K., Sasayama, S. and Honjo, T. Genomics 54 89-98 (1998) 

388. Roles of the ankyrin repeats and C-terminal region of the mouse Notch1 intracellular region. Kurooka, H., Kuroda, K. and Honjo, T. Nucleic Acids Res. 26 5448-5455 (1998) 

389. Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions. Kinoshita, K., Tashiro, J., Tomita, S., Lee, C-G. and Honjo, T. Immunity 9 849-858 (1998) 

390. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. Matsuda, F., Ishii, K., Bourvagnet, P., Kuma, K., Hayashida, H., Miyata, T. and Honjo, T. J. Exp. Med. 188 2151-2162 (1998) 

391. Regulation of interleukin-1b transcription by Epstein-Barr virus involves a number of latent proteins via their interaction with RBP. Krauer, K. G., Belzer, D. K., Liaskou, D., Buck, M., Cross, S., Honjo, T. and Sculley, T. Virology 252 418-430 (1998) 

392. Sponge Pax cDNA related to Pax-2/5/8 and ancient gene duplications in the Pax family. Hoshiyama, D., Suga, H., Iwabe, N., Koyanagi, M., Nikoh, N., Kuma, K., Matsuda, F., Honjo, T. and Miyata, T. J. Mol. Evol. 47 640-648 (1998) 

393. Human S mu binding protein-2 binds to the drug response element and transactivates the human apoA-I promoter: role of gemfibrozil. Mohan, W. S., Chen, Z.-Q., Zhang, X., Khalili, K., Honjo, T.,Deeley, R. G. and Tam, S.-P. J. Lipid. Res. 39 255-267 (1998) 

394. Mechanism of myogenic differentiation suppression by notch and RBP-J. Kurooka, H., Kato, H., Taniguchi, Y., Minoguchi, S., Sakai, T.,Tamura, K. and Honjo, T. Neural Development, Keio University Symposia for Life Science and Medicine (eds. Uyemura, K.,Kawamura, K. and Yazaki, T.) 2 24-28 (1999) 

395. Chromosomal mapping of two RBP-J-related genes: Kyo-T and RBP-L. Tani, S., Taniwaki, M., Taniguchi, Y., Minoguchi, S., Kuroda, K., Han, H., Aoki, T., Miyatake, S., Hashimoto, N. and Honjo, T. J. Hum. Genet. 44 73-75 (1999) 

396. Delta-induced notch signaling mediated by RBP-J inhibits MyoD expression and Myogenesis. Kuroda, K., Tani, S., Tamura, K., Minoguchi, S., Kurooka, H. and Honjo, T. J. Biol. Chem. 274 7238-7244 (1999) 

397. Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kb-inducing kinase. Shinkura, R., Kitada, K., Matsuda, F., Tashiro, K., Ikuta, K., Suzuki, M., Kogishi, K., Serikawa, T. and Honjo, T. Nat. Genet. 22 74-77 (1999) 

398. Isoform specific expression of the SDR-1 protein, a and b in subregions of adult rodent brain. Lopez, N. D., Kinoshita, A., Taniwaki, M., Tada, H., Shirozu, M., Nakano, T., Tashiro, K. and Honjo, T. Biomed. Res. 20 43-49 (1999) 

399. The signal sequence trap method. Tashiro, K., Nakamura, T. and Honjo, T. Methods in Enzymology “cDNA Preparation and Characterization”, Academic Press, (edt. Weissman, S. M.) 303 479-495 (1999) 

400. Requirement of IL-5 for induction of autoimmune hemolytic anemia in anti-red blood cell autoantibody transgenic mice. Sakiyama, T., Ikuta, K., Nisitani, S., Takatsu, K. and Honjo, T. Int. Immunol. 11 995-1000 (1999) 

401. Intracisternal type A particle-mediated activation of the Notch4/int3 gene in a mouse mammary tumor: generation of truncated Notch4/int3 mRNAs by retroviral splicing events. Lee, J.-S., Haruna, T., Ishimoto, A., Honjo, T. and Yanagawa, S. J. Virol. 73 5166-5171 (1999) 

402. Breakage of B cell tolerance and autoantibody production in anti- erythrocyte transgenic mice. Nisitani, S. and Honjo, T. Intern. Rev. Immunol. 18 259-270 (1999) 

403. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. Muramatsu, M., Sankaranand, V. S., Anant, S., Sugai, M., Kinoshita, K., Davidson, N. O. and Honjo, T. J. Biol. Chem. 274 18470-18476 (1999) 

404. Signaling through the antigen receptor of B lymphocytes activates a p53-independent pathway of c-Myc-induced apoptosis. Hagiyama, H., Adachi, T., Yoshida, T., Nomura, T., Miyasaka, N., Honjo, T. and Tsubata, T. Oncogene 18 4091-4098 (1999) 

405. Characterization of mutated protein encoded by partially duplicated fibrillin-1 gene in tight skin (TSK) mice. Saito, S., Nishimura, H., Brumeanu, T.-D., Casares, S., Stan, A. C., Honjo, T. and Bona, C. A. Mol. Immunol. 36 169-176 (1999) 

406. DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries. Nakamura, T., Ruiz-Lozano, P., Lindner, V., Yabe, D., Taniwaki, M., Furukawa, Y., Kobuke, K., Tashiro, K., Lu, Z., Andon, N. L., Schaub, R., Matsumori, A., Sasayama, S., Chien, K. R. and Honjo, T. J. Biol. Chem. 274 22476-22483 (1999) 

407. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Nishimura, H., Nose, M., Hiai, H., Minato, N. and Honjo, T. Immunity 11 141-151 (1999) 

408. Induction of germline transcription in the TCRg locus by Stat5: implications for accessibility control by the IL-7 receptor. Ye, S.-K., Maki, K., Kitamura, T., Sunaga, S., Akashi, K., Domen, J., Weissman, I. L., Honjo, T. and Ikuta, K. Immunity 11 213-223 (1999) 

409. Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells. Kanazawa, N., Nakamura, T., Tashiro, K., Muramatsu, M., Morita, K., Yoneda, K., Inaba, K., Imamura, S. and Honjo, T. Eur. J. Immunol. 29 1925-1932 (1999) 

410. Expression levels of B cell surface immunoglobulin regulate efficiency of allelic exclusion and size of autoreactive B-1 cell compartment. Watanabe, N., Nisitani, S., Ikuta, K., Suzuki, M., Chiba, T. and Honjo, T. J. Exp. Med. 190 461-469 (1999) 

411. Notch signalling controls pancreatic cell differentiation. Apelqvist, ・, Li, H., Sommer, L., Beatus, P., Anderson, D. J., Honjo, T., de Angelis, M. H., Lendahl, U. and Edlund, H. Nature 400 877-881 (1999) 

412. Studies on the cell-type specific expression of RBP-L, a RBP-J family member, by replacement insertion of b-galactosidase. Minoguchi, S., Ikeda, T., Itohara, S., Kaneko, T., Okaichi, H. and Honjo, T. J. Biochem. 126 738-747 (1999) 

413. Murine leukemia provirus-mediated activation of the Nothch1 gene leads to induction of HES-1 in a mouse T lymphoma cell line, DL-3. Lee, J.-S., Ishimoto, A., Honjo, T. and Yanagawa, S. FEBS Letters 455 276-280 (1999) 

414. High pathogenic potential of low-affinity autoantibodies in experimental autoimmune hemolytic anemia. F.-Jimack, L., Reininger, L., Chicheportiche, Y., Clynes, R.,Ravetch, J. V., Honjo, T. and Izui, S. J. Exp. Med. 190 1689-1696(1999) 

415. Regulation of B-1 cell activation and its autoantibody production by Lyn kinase-regulated signallings. Ochi, H., Takeshita, H., Suda, T., Nisitani, S., Honjo, T. and Watanabe, T. Immunology 98 595-603 (1999) 

416. The human immunoglobulin VH locus. Matsuda, F. and Honjo, T. The Immunologist 7/6 171-176 (1999) 

417. Molecular mechanism of immunoglobulin class switch recombination. Kinoshita, K., Lee, C.-G., Tashiro, J., Muramatsu, M., Chen, X.-C., Yoshikawa, K. and Honjo, T. CSH Symposia on Quantitative Biology: Signaling and Gene Expression in the Immune System 64 217-226 (1999) 

418. Lineage-restricted function of nuclear factor kB-inducing kinase (NIK) in transducing signals via CD40. Garceau, N., Kosaka, Y., Masters, S., Hambor, J., Shinkura, R., Honjo, T. and Noelle, R. J. J. Exp. Med. 191 381-385 (2000) 

419. Unique and unprecedented recombination mechanisms in class switching. Kinoshita, K. and Honjo, T. Curr. Opin. Immunol. 12 195-198 (2000) 

420. Identification of a stimulus-dependent DNase I hypersensitive site between the Ia and Ca exons during immunoglobulin heavy chain class switch recombination. Ono, S. J., Zhou, G., Tai, A. K. F., Inaba, M., Kinoshita, K. and Honjo, T. FEBS Lett. 467 268-272 (2000) 

421. B cell tolerance and autoimmunity. Tsubata, T. and Honjo, T. Rev. Immunogenetics 2 18-25 (2000) 

422. Facilitation of b selection and modification of positive selection in the thymus of PD-1-deficient mice. Nishimura, H., Honjo, T. and Minato, N. J. Exp. Med. 191 891-897 (2000) 

423. Markedly different pathogenicity of four Immunoglobulin G isotype-switch variants of an antierythrocyte autoantibody is based on their capacity to interact in vivo with the low-affinity Fcγ Receptor III. Fossati-Jimack, L., Ioan-Facsinay, A., Reininger, L., Chicheportiche, Y., Watanabe, N., Saito, T., Hofhuis, F. M. A., Gessner, J. E., Schiller, C., Schmidt, R. E., Honjo, T., Verbeek, J. S. and Izui, S. J. Exp. Med. 191 1293-1302 (2000) 

424. Alymphoplasia (aly)-type nuclear factor kB-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system. Fagarasan, S., Shinkura, R., Kamata, T., Nogaki, F., Ikuta, K., Tashiro, K. and Honjo, T. J. Exp. Med. 191 1477-1486 (2000) 

425. Functional interaction between the mouse Notch1 intracellular region and histone acetyltransferases PCAF and GCN5. Kurooka, H. and Honjo, T. J. Biol. Chem. 275 17211-17220 (2000) 

426. ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mice. Kato, K., Morrison A. M., Nakano, T., Tashiro, K. and Honjo, T. Blood 96 362-364 (2000) 

427. Increased frequency of surface IgA-positive plasma cells in theintestinal lamina propria and decreased IgA excretion in hyper IgA(HIGA) mice, a murine model of IgA nephropathy with hyperserum IgA. Kamata, T., Nogaki, F., Fagarasan, S., Sakiyama, T., Kobayashi, I., Miyawaki, S., Ikuta, K., Muso, E., Yoshida, H., Sasayama, S. and Honjo, T. J. Immunol. 165 1387-1394 (2000) 

428. Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene. Muto, T., Muramatsu, M., Taniwaki, M., Kinoshita, K. and Honjo, T. Genomics 68 85-88 (2000) 

429. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y. and Honjo, T. Cell 102 553-563 (2000) 

430. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Revy, P., Muto, T., Levy, Y., Geissmann, F., Plebani, A., Sanal, O., Catalan, N., Forveille, M., D.-Lagelouse, R., Gennery, A., Tezcan, I., Ersoy, F., Kayserili, H., Ugazio, A. G., Brousse, N., Muramatsu, M., Notarangelo, L. D., Kinoshita, K., Honjo, T., Fischer, A. and Durandy, A. Cell 102 565-575 (2000) 

431. Netrin-G1: a novel glycosyl Phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins. Nakashiba, T., Ikeda, T., Nishimura, S., Tashiro, K., Honjo, T., Culotti, J. G. and Itohara, S. J. Neuroscience 20 6540-6550 (2000) 

432. Generation, expansion, migration and activation of mouse B1 cells. Fagarasan, S., Watanabe, N. and Honjo, T. Immunol. Rev. 176 205-215 (2000) 

433. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. Freeman, G. j., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L. J., Malenkovich, N., Okazaki, T., Byrne, M. C., Horton, H. F., Fouser, L., Carter, L., Ling, V., Bowman, M. R., Carreno, B. M., Collins, M., Wood, C. R. and Honjo, T. J. Exp. Med. 192 1027-1034 (2000) 

434. T-independent immune response: new aspects of B cell biology. Fagarasan, S. and Honjo, T. Science 290 89-92 (2000) 

435. Induction of skin fibrosis in mice expressing a mutated fibrillin-1 gene. Saito, S., Nishimura, H., Phelps, R. G., Wolf, I., Suzuki, M., Honjo, T. and Bona, C. Mol. Med. 6 825-836 (2000) 

436. Migration and differentiation of autoreactive B-1 cells induced by activated g/d T cells in antierythrocyte immunoglobulin transgenic mice. Watanabe, N., Ikuta, K., Fagarasan, S., Yazumi, S., Chiba, T. and Honjo, T. J. Exp. Med. 192 1577-1586 (2000) 

437. Mechanism of B1 cell differentiation and migration in GALT. Fagarasan, S., Shinkura, R., Kamata, T., Nogaki, F., Ikuta, K. and Honjo, T. Current Topics in Microbiology and Immunology 252 B1 Lymphocytes in B Cell Neoplasia, (eds. Potter, M. and Melchers, F.), Springer-Verlag 221-229 (2000) 

2001-2005

438. Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate. Tanigaki, K., Nogaki, F., Takahashi, J., Tashiro, K., Kurooka, H. and Honjo, T. Neuron 29 45-55 (2001) 

439. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Latchman, Y., Wood, C. R., Chernova, T., Chaudhary, D., Borde, M., Chernova, I., Iwai, Y., Long, A. J., Brown, J. A., Nunes, R., Greenfield, E. A., Bourque, K., Boussiotis, V. A., Carter, L. L., Carreno, B. M., Malenkovich, N., Nishimura, H., Okazaki, T., Honjo, T., Sharpe, A. H. and Freeman, G. J. Nature Immunol. 2261-268 (2001) 

440. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Nishimura, H., Okazaki, T., Tanaka, Y., Nakatani, K., Hara, M., Matsumori, A., Sasayama, S., Mizoguchi, A., Hiai, H., Minato, N. and Honjo, T. Science 291 319-322 (2001) 

441. The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription. Tani, S., Kurooka, H., Aoki, T., Hashimoto, N. and Honjo, T. Nucleic Acids Res. 29 1373-1380 (2001) 

442. Complex layers of genetic alteration in the generation of antibody diversity. Muramatsu, M. and Honjo, T. Trends in Immunol. 22 66-68 (2001) 

443. Palindromic but not G-rich sequences are targets of class switch recombination. Tashiro, J., Kinoshita, K. and Honjo, T. Int. Immunol. 13 495-505 (2001) 

444. The regulation of PD-1/PD-L1 pathway and autoimmune diseases. Okazaki, T., Iwai, Y., Nishimura, H. and Honjo, T. Activating and Inhibitory Immunoglobulin-like Receptors (eds. by Cooper, M. D., Takai, T. and Ravetch, J. V.), Springer-Verlag Tokyo 211-214 (2001) 

445. Histone acetylation determines the developmentally regulated accessibility for T cell receptor g gene recombination. Agata, Y., Katakai, T., Ye, S-K., Sugai, M., Gonda, H., Honjo, T., Ikuta, K. and Shimizu, A. J. Exp. Med. 193 873-879 (2001) 

446. PD-1:an inhibitory immunoreceptor involved in peripheral tolerance. Nishimura, H. and Honjo, T. Trends in Immunol. 22 265-268 (2001) 

447. Elevated plasma stromal cell-derived factor 1 protein level in the progression of HIV type 1 infection/AIDS. Ikegawa, M., Yuan, J., Matsumoto, K., Herrmann, S., Iwamoto, A., Nakamura, T., Matsushita, S., Kimura, T., Honjo, T. and Tashiro, K. Aids Res. Hum. Retroviruses. 17 587-595 (2001) 

448. Linking class-switch recombination with somatic hypermutation. Kinoshita, K. and Honjo, T. Nature Reviews MCB. 2 493-503 (2001) 

449. Induction of germline transcription in the human TCRg locus by STAT51. Lee, H-C., Ye, S-K., Honjo, T. and Ikuta, K. J. Immunol. 167 320-326 (2001) 

450. Differential roles of cytokine receptors in the development of epidermal gd T cells. Ye, S-K., Maki, K., Lee, H-C., Ito, A., Kawai, K., Suzuki, H., Mak, T. W., Chien, Y-h., Honjo, T. and Ikuta, K. J. Immunol. 167 1929-1934 (2001) 

451. Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members. Mizutani, T., Taniguchi, Y., Aoki, T., Hashimoto, N. and Honjo, T. Proc. Natl. Acad. Sci. USA 98 9026-9031 (2001) 

452. Quantitative regulation of class switch recombination by switch region transcription. Lee, C-G., Kinoshita, K., Arudchandran, A., Cerritelli, S. M., Crouch, R. J. and Honjo, T. J. Exp. Med. 194 365-373 (2001) 

453. Human genetic defects in class-switch recombination (hyper-IgM syndromes). Durandy, A. and Honjo, T. Curr. Opin. Immunol. 13 543-548 (2001) 

454. ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury. Kobuke, K., Furukawa, Y., Sugai, M., Tanigaki, K., Ohashi, N., Matsumori, A., Sasayama, S., Honjo, T. and Tashiro, K. J. Biol. Chem. 276 34105-34114 (2001) 

455. In situ class switching and differentiation to IgA-producing cells in the gut lamina propria. Fagarasan, S., Kinoshita, K., Muramatsu, M., Ikuta, K. and Honjo, T. Nature 413 639-643 (2001) 

456. A hallmark of active class switch recombination: transcripts directed by I promoters on looped-out circular DNAs. Kinoshita, K., Harigai, M., Fagarasan, S., Muramatsu, M. and Honjo, T. Proc. Natl. Acad. Sci. USA 98 12620-12623 (2001) 

457. PD-1 immunoreceptor inhibits B cell receptor-mediated signaling byrecruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Okazaki, T., Maeda, A., Nishimura, H., Kurosaki, T. and Honjo, T. Proc. Natl. Acad. Sci. USA 98 13866-13871 (2001) 

458. Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class switch recombination. Chen, X., Kinoshita, K. and Honjo, T. Proc. Natl. Acad. Sci. USA 98 13860-13865 (2001) 

459. The IL-7 receptor controls the accessibility of the TCRg locus by stat5 and histone acetylation. Ye, S-K., Agata, Y., Lee, H-C., Kurooka, H., Kitamura, T., Shimizu, A., Honjo, T. and Ikuta, K. Immunity 15 813-823 (2001) 

460. AID is required to initiate Nbs1/g-H2AX focus formation and mutations at sites of class switching. Petersen, S., Casellas, R., Reina-S-M, B., Chen, H. T., Difilippantonio, M. J., Wilson, P. C., Hanitsch, L., Celeste, A., Muramatsu, M., Pilch, D. R., Redon, C., Ried, T., Bonner, W. M.,Honjo, T., Nussenzweig, M. C. and Nussenzweig, A. Nature 414 660-665 (2001) 

461. Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease1. Higuchi, T., Aiba, Y., Nomura, T., Matsuda, J., Mochida, K., Suzuki, M., Kikutani, H., Honjo, T., Nishioka, K. and Tsubata, T. J. Immunol 168 9-12 (2002) 

462. Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice. Shinohara, M., Ogura, A., Ikegawa, M., Inoue, K., Ogonuki, N., Tashiro, K., Toyokuni, S., Honjo, T. and Shinohara, T. Proc. Natl. Acad. Sci. USA 99 1383-1388 (2002) 

463. Molecular mechanism of class switch recombination: linkage with somatic hypermutation. Honjo, T., Kinoshita, K. and Muramatsu, M. Ann. Rev. Immunol. 20 165-196 (2002) 

464. Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Sm region: Implication to AID involvement in a common step of class switch recombination and somatic hypermutation. Nagaoka, H., Muramatsu, M., Yamamura, N., Kinoshita, K. and Honjo, T. J. Exp. Med. 195 529-534 (2002) 

465. The AID enzyme induces class switch recombination in fibroblasts. Okazaki, I., Kinoshita, K., Muramatsu, M., Yoshikawa, K. and Honjo, T. Nature 416 340-345 (2002) 

466. Fibulin-5/DANCE is essential for elastogenesis in vivo. Nakamura, T., Lozano, P., Ikeda, Y., Iwanaga, Y., Hinek, A., Minamisawa, S., Cheng, C., Kobuke, K., Dalton, N., Takada Y.,Tashiro, K., Ross, J ., Honjo, T. and Chien, K. Nature 415 171-175 (2002) 

467. Switch regions. Kinoshita, K. and Honjo, T. Wiley Encyclopedia of Molecular Medicine 5 3064-3066 (2002) 

468. PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2. Carter, L., Fouser, L., Jussif, J., Fitz, L., Deng, B., Wood, C., Collins, M., Honjo, T., Freeman, G. and Carreno, B. Eur. J. Immunol. 32 634-643 (2002) 

469. Notch receptor cleavage depends on but is not directly executed by presenilins. Taniguchi, Y., Karlstrom, H., Lundkvist, J., Mizutani, T., Otaka, A., Vestling, M., Bernstein, A., Donoviel, D., Lendahl, U. and Honjo, T. Proc. Natl. Acad. Sci. USA 99 4014-4019 (2002) 

470. Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Tanigaki, K., Han, H., Yamamoto, N., Tashiro, K., Ikegawa, M., Kuroda, K., Suzuki, A., Nakano, T. and Honjo, T. Nature Immunol. 3 443-450 (2002) 

471. Experimental models of autoimmune hemolytic anemia. Fagarasan, S., Watanabe, N. and Honjo, T. The Molecular Pathology of Autoimmmune Diseases, Second edition, Edited by Argyrios N. Theofilopoulos and Constantin A. Bona, TAYLOR & FRANCIS 522-542 (2002) 

472. Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Han, H., Tanigaki, K., Yamamoto, N., Kuroda, K., Yoshimoto, M., Nakahata, T., Ikuta, K. and Honjo, T. Int. Immunol. 14 637-645 (2002) 

473. DNA double-strand breaks: Prior to but not sufficient in targeting hypermutation. Bross, L., Muramatsu, M., Kinoshita, K., Honjo, T. and Jacobs, H. J. Exp. Med. 195 1187-1192 (2002) 

474. AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts. Yoshikawa, K., Okazaki, I., Eto, T., Kinoshita, K., Muramatsu, M., Nagaoka, H. and Honjo, T. Science 296 2033-2036 (2002) 

475. Activation and differentiation of autoreactive B-1 cells by interleukin 10 induce autoimmune hemolytic anemia in Fas-deficient anti erythrocyte immunoglobulin transgenic mice. Watanabe, N., Ikuta, K., Nisitani, S., Chiba, T. and Honjo, T. J. Exp. Med. 196 141-146 (2002) 

476. Does AID need another aid? Honjo, T. Nature Immunol. 3 800-801 (2002) 

477. Microanatomical localization of PD-1 in human tonsils. Iwai, Y., Okazaki, T., Nishimura, H., Kawasaki, A., Yagita, H. and Honjo, T. Immunology Letters 83 215-220 (2002) 

478. Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues. Ishida, M., Iwai,Y., Tanaka, Y., Okazaki, T., Freeman, G., Minato, N. and Honjo, T. Immunology Letters 84 57-62 (2002) 

479. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Iwai, Y., Ishida, M., Tanaka, Y., Okazaki, T., Honjo, T. and Minato, N. Proc. Natl. Acad. Sci. USA 99 12293-12297 (2002) 

480. New regulatory co-receptors:inducible co-stimulator and PD-1. Okazaki, T., Iwai, Y. and Honjo, T. Curr. Opin. Immunol. 14 779-782 (2002) 

481. Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Fagarasan, S., Muramatsu, M., Suzuki, K., Nagaoka, H., Hiai, H. and Honjo, T. Science 298 1424-1427 (2002) 

482. Birth of offspring following transplantation of cryopreserved immature testicular pieces and in-vitro microinsemination. Shinohara, T., Inoue, K., Ogonuki, N., Kanatsu-Shinohara, M., Miki, H., Nakata, K., Kurome, M., Nagashima, H., Toyokuni, S., Kogishi, K., Honjo, T. and Ogura, A. Human Reproduction 17 3039-3045 (2002) 

483. Allogeneic offspring produced by male germ line stem cell transplantation into infertile mouse testis. Kanatsu-Shinohara, M., Ogonuki, N., Inoue, K., Ogura, A., Toyokuni, S., Honjo, T. and Shinohara, T. Biology of Reproduction 68 167-173 (2002) 

484. Intestinal IgA synthesis:regulation of front-line body defences. Fagarasan, S. and Honjo, T. Nature Rev. Immunol. 3 63-72 (2003) 

485. Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells. Yamamoto, N., Tanigaki, K., Han, H., Hiai, H. and Honjo, T. Current Biology 13 333-338 (2003) 

486. Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Kuroda, K., Han, H., Tani, S., Tanigaki, K., Tun, T., Furukawa, T., Taniguchi, Y., Kurooka, H., Hamada, Y., Toyokuni, S. and Honjo, T. Immunity 18 301-312 (2003) 

487. De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination. Doi, T., Kinoshita, K., Ikegawa, M., Muramatsu, M. and Honjo, T. Proc. Natl. Acad. Sci. USA 100 2634-2638 (2003) 

488. Recombination signal sequence-binding protein Jk alters mesodermal cell fate decisions by suppressing cardiomyogenesis. Schroeder, T., Fraser, S. T., Ogawa, M., Nishikawa, S., Oka, C., Bornkamm, G. W., Nishikawa, S., Honjo, T. and Just, U. Proc. Natl. Acad. Sci. USA 100 4018-4023 (2003) 

489. Regulation of B cell development by Notch/RBP-J signaling. Tanigaki, K., Kuroda, K., Han, H. and Honjo, T. Semin. Immunol. 15 113-119 (2003) 

490. Activation-induced cytidine deaminase links class switch recombination and somatic hypermutation. Okazaki, I., Yoshikawa, K., Kinoshita, K., Muramatsu, M., Nagaoka, H. and Honjo, T. Ann. N. Y. Acad. Sci. 987 1-8 (2003) 

491. Functional assessment of self-renewal activity of male germline stem cells following cytotoxic damage and serial transplantation. Kanatsu-Shinohara, M., Toyokuni, S., Morimoto, T., Matsui, S., Honjo, T. and Shinohara, T. Biology of Reproduction 68 1801-1807 (2003) 

492. Elimination of local macrophages in intestine prevents chronic colitis in interleukin-10-deficient mice. Watanabe, N., Ikuta, K., Okazaki, K., Nakase, H., Tabata, Y., Matsuura, M., Tamaki, H., Kawanami, C., Honjo, T. and Chiba, T. Digestive Diseases and Sciences 48 408-414 (2003) 

493. Constitutive expression of AID leads to tumorigenesis. Okazaki, I., Hiai, H., Kakazu, N., Yamada, S., Muramatsu, M., Kinoshita, K. and Honjo, T. J. Exp. Med. 197 1173-1181 (2003) 

494. Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. Wang, S., Bajorath, J., Flies, D. B., Dong, H., Honjo, T. and Chen, L. J. Exp. Med. 197 1083-1091 (2003) 

495. Unmutated Immunoglobulin M can protect mice from death by influenza virus infection. Harada, Y., Muramatsu, M., Shibata, T., Honjo, T. and Kuroda, K. J. Exp. Med. 197 1779-1785 (2003) 

496. CD4+PD-1+ T cells accumulate as unique anergic cells in rheumatoid arthritis synovial fluid. Hatachi, S., Iwai, Y., Kawano, S., Morinobu, S., Kobayashi, M., Koshiba, M., Saura, R., Kurosaka, M., Honjo, T. and Kumagai, S. The Journal of Rheumatology 30 1410-1419 (2003) 

497. PD-1 inhibits antiviral immunity at the effector phase in the liver. Iwai, Y., Terawaki, S., Ikegawa, M., Okazaki, T. and Honjo, T. J. Exp. Med. 198 39-50 (2003) 

498. AID mutant analyses indicate requirement for class-switch-specific cofactors. Ta, V-T., Nagaoka, H., Catalan, N., Durandy, A., Fischer, A., Imai, K., Nonoyama, S., Tashiro, J., Ikegawa, M., Ito, S., Kinoshita, K., Muramatsu, M. and Honjo, T. Nature Immunol. 4 843-848 (2003) 

499. Stem cell-derived neural stem/progenitor cell supporing factor is an autocrine/paracrine survival factor for adult neural stem/progenitor cells. Toda, H., Tsuji, M., Nakano, I., Kobuke, K., Hayashi, T., Kasahara, H., Takahashi, J., Mizoguchi, A., Houtani, T., Sugimoto, T., Hashimoto, N., Palmer, T. D., Honjo, T. and Tashiro, K. J. Biol. Chem. 278 35491-35500 (2003) 

500. Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminase. Zhu, Y., Nonoyama, S., Morio, T., Muramatsu, M., Honjo, T. and Mizutani, S. J. Med. Dent. Sci. 50 41-46 (2003) 

501. RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells. Eto, T., Kinoshita, K., Yoshikawa, K., Muramatsu, M. and Honjo, T. Proc. Natl. Acad. Sci. USA 100 12895-12898 (2003) 

502. Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. Okazaki, T., Tanaka, Y., Nishio, R., Mitsuiye, T., Mizoguchi, A.,Wang, J., Ishida, M., Hiai, H., Matsumori, A., Minato, N. and Honjo, T. Nature Medicine 9 1477-1483 (2003) 

503. Absence of programmed death receptor 1 alters thymic development and enhances generation of CD4/CD8 double-negative TCR-transgenic T cells1. Blank, C., Brown, I., Marks, R., Nishimura, H., Honjo, T. and Gajewski, T. F. J. Immunol. 171 4574-4581 (2003) 

504. Molecular mechanism of class switch recombination. Stavnezer, J., Kinoshita, K., Muramatsu, M. and Honjo, T. Molecular Biology of B cells chapter20 307-326 (2004) 

505. Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Suzuki, K., Meek, B., Doi, Y., Muramatsu, M., Chiba, T., Honjo, T. and Fagarasan, S. Proc. Natl. Acad. Sci. USA 101 1981-1986 (2004) 

506. Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1. Ito, S., Nagaoka, H., Shinkura, R., Begum, N., Muramatsu, M., Nakata, M. and Honjo, T. Proc. Natl. Acad. Sci. USA. 101 1975-1980 (2004) 

507. Regulation of IgA synthesis at mucosal surfaces. Fagarasan, S. and Honjo, T. Curr. Opin. Immnol. 16 277-283 (2004) 

508. Instruction of distinct CD4 T helper cell fates by different Notch ligands on antigen-presenting cells. Amsen, D., Blander, J. M., Lee, G. R., Tanigaki, K., Honjo, T. and Flavell, R. A. Cell 117 515-526 (2004) 

509. Regulation of ab/gd T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling. Tanigaki, K., Tsuji, M., Yamamoto, N., Han, H., Tsukada, J., Inoue, H., Kubo, M. and Honjo, T. Immunity 20 611-622 (2004) 

510. AID: how does it aid antibody diversity? Honjo, T., Muramatsu, M. and Fagarasan, S. Immunity 20 659-668(2004) 

511. Separate domains of AID are required for somatic hypermutation and class-switch recombination. Shinkura, R., Ito, S., Begum, N. A., Nagaoka, H., Muramatsu, M., Kinoshita, K., Sakakibara, Y., Hijikata, H. and Honjo, T. Nature Immunol. 5 707-712 (2004) 

512. Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch. Begum, N. A., Kinoshita, K., Kakazu, N., Muramatsu, M., Nagaoka, H., Shinkura, R., Biniszkiewicz, D., Boyer, L. A., Jaenisch, R. and Honjo, T. Science 305 1160-1163 (2004) 

513. De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination. Begum, N. A., Kinoshita, K., Muramatsu, M., Nagaoka, H., Shinkura, R. and Honjo, T. Proc. Natl. Acad. Sci. USA. 101 13003-13007 (2004) 

514. AID is required for c-myc/IgH chromosome translocations in vivo. Ramiro, A. R., Jankovic, M., Eisenreich, T., Difilippantonio, S., Chen-Kiang, S., Muramatsu, M., Honjo, T., Nussenzweig, A. and Nussenzweig, M. C. Cell 118 431-438 (2004) 

515. B1b lymphocytes confer T cell-independent long-lasting immunity. Alugupalli, K. R., Leong, J. M., Woodland, R. T., Muramatsu, M., Honjo, T. and Gerstein, R. M. Immunity 21 379-390 (2004) 

516. Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Krebs, L. T., Shutter, J. R., Tanigaki, K., Honjo, T., Stark, K. L. and Gridley, T. Genes Dev. 18 2469-2473 (2004) 

517. Expression of Btcl2, a novel member of Btcl gene family, during development of the central nervous system. Michishita, M., Ikeda, T., Nakashiba, T., Ogawa, M., Tashiro, K., Honjo, T., Doi, K., Itohara, S. and Endo, S. Developmental Brain Research 153 135-142 (2004) 

518. OC29 is preferentially expressed in the presumptive sensory organ region of the otocyst. Nishida, A. T., Kobuke, K., Kojima, K., Ito, J., Honjo, T. and Tashiro, K. Developmental Dynamics 231 766-774 (2004) 

*519. Yasutomi Nishizuka Obituary. Honjo, T. Nature 432 966 (2004) 

*520. Response to comment on “Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch”. Begum, N. A. and Honjo, T. Science 306 2042c (2004) 

521. PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells. Iwai, Y., Terawaki, S. and Honjo, T. Int. Immunol. 17 133-144 (2004) 

522. DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase. Nagaoka, H., Ito, S., Muramatsu, M., Nakata, M. and Honjo, T. Proc. Natl. Acad. Sci. USA. 102 2022-2027 (2005) 

523. Two distinctive pathways for recruitment of na夫e and primed IgM+ B cells to the gut lamina propria. Suzuki, K., Meek, B., Doi, Y., Honjo, T. and Fagarasan, S. Proc. Natl. Acad. Sci. USA. 102 2482-2486 (2005) 

524. Resting dendritic cells induce peripheral CD8+ T cell torelance through PD-1 and CTLA-4. Probst, H. C., McCoy, K., Okazaki, T., Honjo, T. and van den Broek, M. Nature Immunol. 6 280-286 (2005) 

525. A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression. Kotani, A., Okazaki, I., Muramatsu, M., Kinoshita, K., Begum, N. A., Nakajima, T., Saito, H. and Honjo, T. Proc. Natl. Acad. Sci. USA. 102 4506-4511 (2005) 

526. Pathogenic roles of cardiac autoantibodies in dilated cardiomyopathy. Okazaki, T. and Honjo, T. Trends in Molecular Medicine 11 322-326 (2005) 

527. AID to overcome the limitation of genomic information. Honjo, T., Nagaoka, H., Shinkura, R. and Muramatsu, M. Nat. Immunol. 6 655-661 (2005) 

528. Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes. Wang, J., Yoshida, T., Nakaki, F., Hiai, H., Okazaki, T. and Honjo, T. Proc. Natl. Acad. Sci. USA. 102 11823-11828 (2005) 

*529. In search of the best granting system. Honjo, T. Science 309 1329 (2005) 

530. Enhanced expression of programmed death-1 (PD-1) / PD-L1 in salivary glands of patients with Sj　 grenﾕs syndrome. Kobayashi, M., Kawano, S., Hatachi, S., Kurimoto, C., Okazaki, T., Iwai, Y., Honjo, T., Tanaka, Y., Minato, N., Komori, T., Maeda, S. and Kumagai, S. J. of Rheumatology 32 2156-2163 (2005) 

531. Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID. Wakae, K., Magor, B. G., Saunders, H., Nagaoka, H., Kawamura, A., Kinoshita, K., Honjo, T. and Muramatsu, M. Int. Immunol. 18 41-47 (2005) 

532. Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice. Okazaki, T., Otaka, Y., Wang, J., Hiai, H., Takai, T., Ravetch, J. V. and Honjo, T. J. Exp. Med. 202 1643-1648 (2005) 

2006-2010

533. Inhibition of Notch / RBP-J signaling induces hair cell formation in neonate mouse cochleas. Yamamoto, N., Tanigaki, K., Tsuji, M., Yabe, D., Ito, J. and Honjo, T. J. Mol. Med. 84 37-45 (2006) 

534. Rejuvenating exhausted T cells during chronic viral infection. Okazaki, T. and Honjo, T. Cell 124 459-461 (2006) 

535. Negative regulation of activation-induced cytidine deaminase in B cells. Muto, T., Okazaki, I., Yamada, S., Tanaka, Y., Kinoshita, K., Muramatsu, M., Nagaoka, H. and Honjo, T. Proc. Natl. Acad. Sci. USA. 103 2752-2757 (2006) 

536. Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas. Fujikura, J., Hosoda, K., Iwakura, H., Tomita, T., Noguchi, M., Masuzaki, H., Tanigaki, K., Yabe, D., Honjo, T. and Nakao, K. Cell Metabolism 3 1-7 (2006) 

537. PD-1/PD-L pathway in immunological tolerance. Okazaki, T. and Honjo, T. Trends Immunol. 27 195-201 (2006) 

538. AID to overcome the limitations of genomic information by introducing somatic DNA alterations. Honjo, T., Muramatsu, M., Nagaoka, H., Kinoshita, K. and Shinkura, R. Proc. Japan. Acad. Ser. B 82 104-120 (2006) 

539. The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy. Buono, K. D., Robinson, G. W., Martin, C., Shi, S., Stanley, P., Tanigaki, K., Honjo, T. and Hennighausen, L. Developmental Biol. 293 565-580 (2006) 

540. The Interleukin-4 Enhancer CNS-2 Is Regulated by Notch Signals and Controls Initial Expression in NKT Cells and Memory-Type CD4 T Cells. Tanaka, S., Tsukada, J., Suzuki, W., Hayashi, K., Tanigaki, K., Tsuji, M., Inoue, H., Honjo, T. and Kubo, M. Immunity 24 689-701 (2006) 

* The 20th IUBMB International Congress in Kyoto. Ikuta, K., Kageyama, R. and Honjo, T. IUBMB Life 58 258 (2006) 

541. Identification of a specific domain required for dimerization of activation-induced cytidine deaminase. Wang, J., Shinkura, R., Muramatsu, M., Nagaoka, H., Kinoshita, K. and Honjo, T. J. Biol. Chem. 281 19115-19123 (2006) 

542. Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination. Begum, A. N., Izumi, N., Nishikori, M., Nagaoka, H., Shinkura, R. and Honjo, T. J. Biol. Chem. 282 731-742 (2007) 

543. Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling. Tsuji, M., Shinkura, R., Kuroda, K., Yabe, D. and Honjo, T. Proc. Natl. Acad. Sci. USA. 104 1610-1615 (2007) 

544. Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice. Kotani, A., Kakazu, N., Tsuruyama, T., Okazaki, I., Muramatsu, M., Kinoshita, K., Nagaoka, H., Yabe, D. and Honjo, T. Proc. Natl. Acad. Sci. USA. 104 1616-1620 (2007) 

545. AID-/- ｵs-/- mice are agammaglobulinemic and fail to maintain B220-CD138+ plasma cells1. Kumazaki, K., Tirosh, B., Maehr, R., Boes, M., Honjo, T. and Ploegh, H. L. J. Immunol. 178 2192-2203 (2007) 

546. Regulation of AID function in vivo. Shinkura, R., Okazaki, I., Muto, T., Begum, N. A. and Honjo, T. Advances in Experimental Medicine and Biology 596 71-81 (2007) 

547. Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Hamanishi, J., Mandai, M., Iwasaki, M., Okazaki, T., Tanaka, Y., Yamaguchi, K., Higuchi, T., Yagi, H., Takakura, K., Minato, N., Honjo, T. and Fujii, S. Proc. Natl. Acad. Sci. USA. 104 3360-3365 (2007) 

*548. Regulation of lymphocyte development by Notch signaling.(Review) Tanigaki, K. and Honjo, T. Nature Immunol. 8 451-456 (2007) 

549. Generation of a conditional knockout allele for mammalian spen protein Mint/SHARP. Yabe, D., Fukuda, H., Aoki, M., Yamada, S., Takebayashi, S., Shinkura, R., Yamamoto, N. and Honjo, T. Genesis 45 300-306 (2007) 

550. Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Matsumoto, Y., Marusawa, H., Kinoshita, K., Endo, Y., Kou, T., Morisawa, T., Azuma, T., Okazaki, I., Honjo, T. and Chiba, T. Nature Medicine 13 470-476 (2007) 

551. Expression of activation-induced cytidine deaminase in human hepatocytes via NF-kB signaling. Endo, Y., Marusawa, H., Kinoshita, K., Morisawa, T., Sakurai, T., Okazaki, I., Watashi, K., Simotohno, K., Honjo, T. and Chiba, T. Oncogene 000-000 (2007) 

552. Discovery of activation-induced cytidine deaminase, the engraver of antibody memory. Muramatsu, M., Nagaoka, H., Shinkura, R., Begum, N. A. and Honjo, T. Advances in Immunology 94 000-000 (2007) 

553. Role of AID in tumorigenesis. Okazaki, I., Kotani, I. and Honjo, T. Advances in Immunology 94 000-000 (2007) 

554. PD-1 and PD-1 ligands: from discovery to clinical application. (Review) Okazaki, T. and Honjo, T. Int. Immunol. 19 813-824 (2007) 

555. Specific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells: possible application to enhance T cell function. Terawaki, S., Tanaka, Y., Nagakura, T., Hayashi, T., Shibayama, S., Muroi, K., Okazaki, T., Mikami, B., Garboczi, D. N., Honjo, T. and Minato, N. Int. Immunol. 19 881-890 (2007) 

556. AID-deficient Bcl-xL trangenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements. Kovalchuk, A. L., duBois, W., Mushinski, E., McNeil, N. E., Hirt, C., Qi, C.-F., Li, Z., Janz, S., Honjo, T., Muramatsu, M., Ried, T., Behrens, T. and Potter, M. J. Exp. Med. 204 2989-3001 (2007) 

557. The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling. Komine, O., Nagaoka, M., Watase, K., Gutmann, D. H., Tanigaki, K., Honjo, T., Radtke, F., Saito, T., Chiba, S. and Tanaka, K. Developmental Biol. 311 238-250 (2007) 

558. AID is required for germinal center-derived lymphomagenesis. Pasqualucci, L., Bhagat, G., Jankovic, M., Compagno, M., Smith, P., Muramatsu, M., Honjo, T., Morse, H. C. 3rd, Nussenzweig, M. C. and Dalla-Favera, R. Nat. Genet. 40 108-112 (2008) 

559. A memoir of AID, which engraves antibody memory on DNA. Honjo, T. Nature Immunol. 9 335-337 (2008) 

560. Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants. Shivarov, V., Shinkura, R. and Honjo, T. Proc. Natl. Acad. Sci. USA. 105 15866-15871 (2008) 

561. The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors. Lin, D. Y., Tanaka, Y., Iwasaki, M., Gittis, A. G., Su, H-P., Mikami, B., Okazaki, T., Honjo, T., Minato, N. and Garboczi, D. N. Proc. Natl. Acad. Sci. USA. 105 3011-3016 (2008) 

562. PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice. Yoshida, T., Jiang, F., Honjo, T. and Okazaki, T. Proc. Natl. Acad. Sci. USA. 105 3533-3538 (2008) 

563. Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDKinhibitors p27Kip1 and p57Kip2. Riccio, O., van Gijn, M. E., Bezdek, A. C., Pellegrinet, L., van Es, J. H., Zimber-Strobl, U., Strobl, L. J., Honjo, T., Clevers, H. and Radtke, F. EMBO Rep. 9 377-383 (2008) 

564. The programmed death-1 and interleukin-10 pathways play a down-modulatory role in LP-BM5 retrovirus-induced murine immunodeficiency syndrome. Green, K. A., Okazaki, T., Honjo, T., Cook, W. J. and Green, W. R. J. Virol. 82 2456-2469 (2008) 

565. Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers. Endo, Y., Marusawa, H., Kou, T., Nakase, H., Fujii, S., Fujimori, T., Kinoshita, K., Honjo, T. and Chiba, T. Gastroenterology 135 889-898 (2008) 

566. Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling. Kido, M., Watanabe, N., Okazaki, T., Akamatsu, T., Tanaka, J., Saga, K., Nishio, A., Honjo, T. and Chiba, T. Gastroenterology 135 1333-1343 (2008) 

567. Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression. Morisawa, T., Marusawa, H., Ueda, Y., Iwai, A., Okazaki, I., Honjo, T. and Chiba, T. Int. J. Cancer 123 2735-2740 (2008) 

568. Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cell is dependent on the PD-1/PD-L1 pathway. Haspot, F., Fehr, T., Gibbons, C., Zhao, G., Hogan, T., Honjo, T., Freeman, G. J. and Sykes, M. Blood 112 2149-2155 (2008) 

569. A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations. Takai, A., Toyoshima, T., Uemura, M., Kitawaki, Y., Marusawa, H., Hiai, H., Yamada, S., Okazaki, I., Honjo, T., Chiba, T. and Kinoshita, K. Oncogene 28 469-478 (2009) 

570. Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Carlen, M., Meletis, K., Goritz, C., Darsalia, V., Evergren, E., Tanigaki, K., Amendola, M., Barnabe-Heider, F., Yeung, M. S. Y., Naldini, L., Honjo, T., Kokaia, Z., Shupliakov, O., Cassidy, R. M., Lindvall, O. and Frisen, J. Nat. Neurosci. 12 259-267 (2009) 

571. Carboxy-terminal domain of AID required for its mRNA complex formation in vivo. Nonaka, T., Doi, T., Toyoshima, T., Muramatsu, M., Honjo, T. and Kinoshita, K. Proc. Natl. Acad. Sci. USA 106 2747-2751 (2009) 

572. Further evidence for involvement of a non-canonical function of uracil DNA glycosylase in class switch recombination. Begum, N. A., Stanlie, A., Doi, T., Sasaki, Y., Jin, H. W., Kim, Y.S., Nagaoka, H. and Honjo, T. Proc. Natl. Acad. Sci. USA 106 2752-2757 (2009) 

573. The C-terminal region of AID is responsible for a novel function other than DNA cleavage in class switch recombination. Doi, T., Kato, L., Ito, S., Shinkura, R., Wei, M., Nagaoka, H., Wang, J. and Honjo, T. Proc. Natl. Acad. Sci. USA 106 2758-2763 (2009) 

574. Molecular mechanism for generation of antibody memory. Shivarov, V., Shinkura, R., Doi, T., Begum, N. A., Nagaoka, H., Okazaki, I., Ito, S., Nonaka, T., Kinoshita, K. and Honjo, T. Phil. Trans. R. Soc. B 364 569-575 (2009) 

575. Preferential generation of follicular B helper T (TFH) cells from Foxp3+ T cells in gut Peyer’s patches. Tsuji, M., Komatsu, N., Kawamoto, S., Suzuki, K., Kanagawa, O., Honjo, T., Hori, S and Fagarasan, S. Science 323 1488-1492 (2009) 

576. Identification of QTLs that modify peripheral neuropathy in NOD.H2b-Pdcd1-/-mice. Jiang, F., Yoshida, T., Nakaki, F., Terawaki, S., Chikuma, S., Kato, Y., Okazaki, I., Honjo, T. and Okazaki, T. Int. Immunol. 21 499-509 (2009) 

577. Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus. Wojciechowski, W., Harris, D. P., Sprague F., Mousseau, B., Makris, M., Kusser, K., Honjo, T., Mohrs, K., Mohrs, M., Randall, T. and Lund, F. E. Immunity 30 421-433 (2009) 

578. PD-1-mediated suppression of IL-2 production induces CD8+ T-cell anergy in vivo. Chikuma, S., Terawaki, S., Hayashi, T., Nabeshima, R., Yoshida, T., Shibayama, S., Okazaki, T and Honjo, T. J. Immunol. 182 6682-6689 (2009) 

579. Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes. Sabouri, Z., Okazaki, I., Shinkura, R., Begum, N. A., Nagaoka, H., Tsuchimoto, D., Nakabeppu, Y. and Honjo, T. Int. Immunol. 21 947-955 (2009) 

C-4. Letters to the Editor-in-Chief: The role of Apex2 in class-switch recombination of immunoglobulin genes. Guikema, J. E. J., Stavnezer, J. and Schrader, C. E. Int. Immunol. 22 213 (2010) 

C-5. Author’s reply: Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes. Sabouri, Z., Okazaki, I., Shinkura, R., Begum, N. A., Nagaoka, H., Tsuchimoto, D., Nakabeppu, Y. and Honjo, T. Int. Immunol. 22 213-214 (2010) 

580. RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis. Fujimoto, M., Takagi, Y., Muraki, K., Nozaki, K., Yamamoto, N., Tsuji, M., Hashimoto, N., Honjo, T. and Tanigaki, K. Developmental Biology 332 339-350 (2009) 

581. AID-induced decrease in topoisomerase 1 induces DNA structural alteration　and DNA cleavage for class switch recombination. Kobayashi, M., Aida, M., Nagaoka, H., Begum, N. A., Kitawaki, Y., Nakata, M., Stanlie, A., Doi, T., Kato, L., Okazaki, I., Shinkura R., Muramatsu, M., Kinoshita, K. and Honjo, T. Proc. Natl. Acad. Sci. USA 106 22375-22380 (2009) 

582. B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers. Tran, T. H., Nakata, M., Suzuki, K., Begum, N. A., Shinkura, R., Fagarasan, S., Honjo, T. and Nagaoka, H. Nat. Immunol. 11 148-155 (2010) 

C-6. Walking the AID tightrope. Lee-Theilen, M. and Chaudhuri, J. Nat. Immunol. 11 107-109 (2010) 

583. Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice. Kasagi, S., Kawano, S., Okazaki, T., Honjo, T., Morinobu, A., Hatachi, S., Shimatani, K., Tanaka, Y., Minato, N. and Kumagai, S. J. Immunol. 184 2337-2347 (2010) 

584. Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma. Hino, R., Kabashima, K., Kato, Y., Yagi, H., Nakamura, M., Honjo, T., Okazaki, T. and Tokura, Y. Cancer 116 1757-1766 (2010) 

585. Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity. (Review) Nagaoka, H., Tran, T. H., Kobayashi, M., Aida, M. and Honjo, T. Int. Immunol. 22 227-235 (2010) 

586. RBPj{kappa}-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Dong, Y., Jesse, A. M., Kohn, A., Gunnell, L. M., Honjo, T., Zuscik, M. J., O’Keefe, R. J. and Hilton, M. J. Development 137 1461-1471 (2010) 

587. AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model. Komeno, Y., Kitaura, J., Watanabe-Okochi, N., Kato, N., Oki, T., Nakahara, F., Harada, Y., Harada, H., Shinkura, R., Nagaoka, H., Hayashi, Y., Honjo, T. and Kitamura, T. Leukemia 24 1018-1024 (2010) 

588. PD-1 deficiency results in the development of fatal myocarditis in MRL mice. Wang, J., Okazaki, I., Yoshida, T., Chikuma, S., Kato, Y., Nakaki, F., Hiai, H., Honjo, T. and Okazaki, T. Int. Immunol. 22 443-452 (2010) 

589. X4 and R5 HIV-1 have distinct post-entry requirements for uracil DNA glycosylase during infection of primary cells. Jones, K. L., Roche, M., Gantier, M. P., Begum, N. A., Honjo, T., Caradonna, S., Williams, B. R. G. and Mak, J. J. Biol. Chem. 285 18603-18614 (2010) 

590. Two opposing roles of RBP-J in Notch signaling. Tanigaki, K. and Honjo, T. Curr. Top. Dev. Biol. 92 231-252 (2010) 

591. Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL. Jeannet, R., Mastio, J., Macias-Garcia, A., Oravecz, A., Ashworth, T., Geimer Le Lay, A. S., Jost, B., Le Gras, S., Ghysdael, J., Gridley, T., Honjo, T., Radtke, F., Aster, J. C., Chan, S. and Kastner, P. Blood 116 5443-5454 (2010) 

592. Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination. Stanlie, A., Aida, M., Muramatsu, M., Honjo, T. and Begum, N. A. Proc. Natl. Acad. Sci. USA 107 22190-22195 (2010) 

2011-2016

593. Complex interplay between {beta}-catenin signalling and Notch effectors in intestinal tumorigenesis. Peignon, G., Durand, A., Cacheux, W., Ayrault, O., Terris, B., Laurent-Puig, P., Shroyer, N. F., Van Seuningen, I., Honjo, T., Perret, C. and Romagnolo, B. Gut 60 166-176 (2011) 

594. Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense. Wei, M., Shinkura, R., Doi, Y., Maruya, M., Fagarasan, S. and Honjo, T. Nat. Immunol. 12 264-270 (2011) 

C-7. AIDing the pursuit of IgA diversity. Chen, K. and Cerutti, A. Nat. Immunol. 12 197-198 (2011) 

595. IFN-{alpha} directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity. Terawaki, S., Chikuma, S., Shibayama, S., Hayashi, T., Yoshida, T., Okazaki, T. and Honjo, T. J. Immunol. 186 2772-2779 (2011) 

C-8. In this issue. J. Immunol. 186 2689-2690 (2011) 

596. PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice. Okazaki, T., Okazaki, I., Wang, J., Sugiura, D., Nakaki, F., Yoshida, T., Kato, Y., Fagarasan, S., Muramatsu, M., Eto, T., Hioki, K. and Honjo, T. J. Exp. Med. 208 395-407 (2011) 

597. Regulation of Trypanosoma cruzi-induced myocarditis by programmed death cell receptor 1 (PD-1). Gutierrez, F. R. S., Mariano, F. S., Oliveira, C. J. F., Pavanelli, W. R., Guedes, P. M. M., Silva, G. K., Campanelli, A. P., Milanezi, C. M., Azuma, M., Honjo, T., Teixeira, M. M., Aliberti, J. C. S. and Silva, J. S. Infect. Immun. 79 1873-1881 (2011) 

598. Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation. Okazaki, I., Okawa, K., Kobayashi, M., Yoshikawa, K., Kawamoto, S., Nagaoka, H., Shinkura, R., Kitawaki, Y., Taniguchi, H., Natsume, T., Iemura, S. and Honjo, T. Proc. Natl. Acad. Sci. USA 108 7920-7925 (2011) 

C-9. Highlights: Identification of a key player in the regulation of antibody production by B cells represents a significant advance in the understanding of the immune system. A-IMBN Research, Asia-Pacific International Molecular Biology Network and Nature Japan K.K., trading as NPG Nature Asia-Pacific (2011) 

599. Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation. Kobayashi, M., Sabouri, Z., Sabouri, S., Kitawaki, Y., Pommier, Y., Abe, T., Kiyonari, H. and Honjo, T. Proc. Natl. Acad. Sci. USA 108 19305-19310 (2011) 

600. Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age. Qin, H., Suzuki, K., Nakata, M., Chikuma, S., Izumi, N., Le, T. H., Maruya, M., Fagarasan, S., Busslinger, M., Honjo, T. and Nagaoka, H. PLoS One 6 e29141 (2011) 

601. Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes. Kato, L., Begum, N.A., Burroughs, A.M., Doi, T., Kawai, J., Daub, C.O., Kawaguchi, T., Matsuda, F., Hayashizaki, Y. and Honjo, T. Proc. Natl. Acad. Sci. USA 109 2479-2484 (2012) 

602. Cartilage-specific RBPj–dependent and -independent Notch signals regulate cartilage and bone development. Kohn, A., Dong, Y., Mirando, A.J., Jesse, A.M., Honjo, T., Zuscik, M.J., O’Keefe, R.J. and Hilton, M.J. Development 139 1198-212 (2012) 

603. The AID dilemma: infection, or cancer? Honjo, T., Kobayashi, M., Begum, N.A., Kotani, A., Sabouri, S. and Nagaoka, H. Adv. Cancer Res. 113 1-44 (2012) 

604. An evolutionary view of the mechanism for immune and genome diversity. Kato, L, Stanlie, A, Begum, N.A., Kobayashi, M., Aida, M. and Honjo, T. J. Immunol. 188 3559-3566 (2012) 

605. The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombination. Stanlie, A., Begum, N.A., Akiyama, H. and Honjo, T. PLoS Genet. 8 e1002675 (2012) 

C-10. Highlights – Clarifying role changes in the immune system: Molecular manipulation reveals how antibodies can switch classes and effect a different type of immune response. A-IBMN Research, Asian-Pacific International Molecular Biology Network and Nature Japan K.K., trading as NPG Nature Asia-Pacific (2012) 

606. TRIM28 prevents autoinflammatory T cell development in vivo. Chikuma, S, Suita, N., Okazaki, I., Shibayama, S. and Honjo, T. Nat. Immunol. 13 596-603 (2012) 

C-11. Tumor immunotherapy directed at PD-1. Ribas, A. N. Engl. J. Med. 366 2517-2519 (2012) 

607. Evolutionary comparison of the mechanism of DNA cleavage with respect to immune diversity and genomic instability. Begum, N.A. and Honjo, T. Biochemistry 51 5243-5256 (2012) 

608. The histone chaperone SPT6 is required for Activation-induced Cytidine Deaminase target determination through H3K4me3 regulation. Begum, N.A., Stanlie, A., Nakata, M., Akiyama, H. and Honjo, T. J. Biol. Chem. 287 32415-32429 (2012) 

609. RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase. Liang, G., Kitamura, K., Wang, Z., Liu, G., Chowdhury, S., Fu, W., Koura, M., Wakae, K., Honjo, T. and Muramatsu, M. Proc. Natl. Acad. Sci. USA 110 2246-2251 (2013) 

610. Accumulation of the FACT complex as well as histone H3.3 serves as a target marker for somatic hypermutation. Aida, M., Hamad, N., Stanlie, A., Begum, N.A. and Honjo, T. Proc Natl Acad Sci U S A 110 7784-7789 (2013) 

611. In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression. Huong, L.T, Kobayashi, M., Nakata, M., Shioi, G., Miyachi, H., Honjo, T. and Nagaoka, H. PLoS One 8 e61433 (2013) 

612. FACT and H3.3: New markers for the somatic hypermutation. Aida, M. and Honjo, T. Cell Cycle 12 2923-2924 (2013) 

613. Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response. Rui, Y., Honjo, T. and Chikuma, S. Proc. Natl. Acad. Sci. USA 110 16073-16078 (2013) 

614. A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application. Okazaki, T., Chikuma, S., Iwai, Y., Fagarasan, S. and Honjo, T. Nat. Immunol. 14 1212-1218 (2013) 

C-12. Cancer immunotherapy. Couzin-Frankel, J. Science 342 1432 (2013) 

615. Low-affinity IgM antibodies lacking somatic hypermutations are produced in the secondary response of C57BL/6 mice to (4-hydroxy-3-nitrophenyl)acetyl hapten. Murakami, A., Moriyama, H., Osako-Kabasawa, M., Endo, K., Nishimura, M., Udaka, K., Muramatsu, M., Honjo, T., Azuma, T. and Shimizu, T. Int. Immunol. 26 195-208 (2014) 

616. The C-terminal region of AID is required for efficient class switch recombination and gene conversion. Sabouri, S., Kobayashi, M., Begum, N.A., Xu, J., Hirota, K. and Honjo, T. Proc. Natl. Acad. Sci. USA 111 2253-2258 (2014) 

617. Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models. Nguyen, T., Xu, J., Chikuma, S., Hiai, H., Kinoshita, K., Moriya, K., Koike, K., Marcuzzi, G. P., Pfister, H., Honjo, T. and Kobayashi, M. Int. Immunol. 26 397-406 (2014) 

618. Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase. Yousif, A. S., Stanlie, A., Mondal, S., Honjo, T. and Begum, N. A. Proc. Natl. Acad. Sci. USA 111 E1016-E1024 (2014) 

619. Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining Stanlie, A.,Yousif, A. S., Akiyama, H., Honjo, T. and Begum, N. A. Mol.Cell 55, 97-110 (2014) 

620. Opinion:uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination. Yousif, A. S., Stanlie, A., Begum, N. A. and Honjo, T. Int. Immunol. 26 575-578 (2014) 

621. APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination.
Xu, J., Husain, A., Hu, W., Honjo, T. and Kobayashi, M. Proc. Natl. Acad. Sci. USA 111 17242-17247 (2014) 

622. Molecular Mechanisms of AID Function. Begum, N.A., Nagaoka, H., M. Kobayashi and Honjo, T.
Chapter 18, Molecular Biology of B Cells Second Edition, Elsevier (2015) 

623. Identification of DNA cleavage- and recombination-specific hnRNP co-factors for Activation-induced cytidine deaminase. Hu, W., Begum, N. A., Mondal, S., Stanlie, A. and Honjo, T. Proc. Natl. Acad. Sci. USA 112 5791-5796 (2015)

624. Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer. Hamanishi, J., Mandai, M., Ikeda, T., Minami, M., Kawaguchi, A., Murayama, T., Kanai, M., Mori, Y., Matsumoto, S., Chikuma, S., Matsumura, N., Abiko, K., Baba, T., Yamaguchi, K., Ueda, A., Hosoe, Y., Morita, S., Yokode, M., Shimizu, A., Honjo, T. and Konishi, I. J. Clin. Oncol., Vol. 33, No. 34, 4015-4022, Dec. 1, 2015 (2015) 

625. Chromatin remodeler SMARCA4 recruits topoisomerase 1 and suppresses transcription associated genomic instability. Husain, A. Begum, N. A., Kobayashi, M. and Honjo, T. Nature Communications DOI: 10.10 38/ncomms10549 (2016) 

626. Functional requirements of AID’s higher order structure and interaction with RNA-binding proteins.
Mondal, S., Begum, N. A., Hu, W. and Honjo, T. PNAS E1545-E1554, Feb. 29, 2016 (2016) 

627. Cancer Immunotherapy by Checkpoint Blockade. Minato, N. and Honjo, T. Chapter 29 Second Edition of theVaccine Book, Academic Press, 2016 

628. Non-overlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model. Zhang, B., Chikuma, S., Hori, S., Fagarasan, S. and Honjo, T. PNAS, Vol. 113, No. 30 8490-8495, July 26, 2016 (2016) 

2017~現在

629. Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity. Chamoto, K., Chowdhury, P. S., Kumar, A., Sonomura, K., Matsuda, F., Fagarasan, S. and Honjo, T. PNAS, 2017 January 31; 114(5) E761-E770 (2017) 

630. The novel activation-induced deoxycytidine deaminase (AID) mutants, AIDv and AIDvΔ15 are defective in SHM and CSR. Kobayashi, M., Takemoto, M. and Honjo, T. DNA Repair 53 (2017) 1-3 

631. Cancer immunotherapies targeting the PD-1 signaling pathway. Iwai, Y., Hamanishi, J., Chamoto, K. and Honjo, T.  Journal of Biomedical Science (2017) 24:26 

632. Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi a Mouse Model of Systemic Lupus with Knocked-in Heavy and Light Chain Genes. McDonald, G., Medina, C., Pilichowska, M., Kearney, J., Shinkura, R., Selsing, E., Wortis, H., Honjo, T. and Imanishi-Kari, T.  Frontiers in Immunology, September 2017, Volume 8, Article 1094 

633. Role of PD-1 in Immunity and Diseases. Chamoto, K., Al-Habsi, M. and Honjo, T. Current Topics in Microbiology and Immunology 82 2017, Chapter 67 

634. Depletion of recombination specific co-factors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination. Ismail, A., Husain, A., Kobayashi, M., Honjo, T. and Begum, N. International Immunology 29 11 525-537 doi:10.1093/intimm/dxx061 (2017) 

635. Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior. Miyajima, M., Zhang, B., Sugiura, Y., Sonomura, K., Guerrini, M., Tsutsui, Y., Maruya, M., Vogelzang, A., Chamoto, K., Honda, K., Hikida, T., Ito, S., Qin, H., Sunai, R., Suzuki, K., Furukawa, T., Ishihama, Y., Matsuda, F., Suematsu, M., Honjo, T. and Fagrasan, S. Nat. Immunol. 18 12 1342-1352 doi:10.1038/ni.3867 (2017) 

636. Combination therapy strategies for improving PD-1 blockade efficiency: A new era in cancer imunotherapy. Chowdhury, P., Chamoto, K. and Honjo, T. Journal of Internal Medicine 283 110-120 (2018) 

637. PPAR-induced fatty acid oxidation in T cells increases the number of tumor-reactive CD8+ T cells and facilitates anti-PD-1 therapy. Chowdhury, P., Chamoto, K., Kumar A. and Honjo, T. Cancer Immunol. Res. DOI: 10.1158/2326-6066.CIR-18-0095 (2018) 

638. Apurinic/apyrimidinic endonuclease 1 (APE1) is dispensable for activation-induced cytidine
deaminase (AID)-dependent somatic hypermutation in the immunoglobulin gene.Islam, H., Kobayashi, M. and Honjo, T. International Immunology, doi:10.1093/intimm/dxz028 (2019) 

639. Analytical performance of a new automated chemiluminescent magnetic immunoassays for solubel PD-1. PD-L1, and CTLA-4 in human plasma.Goto, M., Chamoto, K., Higuchi1, K., Yamashita, S., Noda, K., Iino, T., Miura, M., Yamasaki, T., Ogawa, O., Sonobe, M., Date, H., Hamanishi, J., Mandai, M., Tanaka, Y., Chikuma, S., Hatae, R., Muto, M., Minamiguchi, S., Minato, N. and Honjo, T. Scientific Reports (2019) 9:10144 , doi:10.1038/s41598-019-46548-3 (2019) 

640. Current issues and perspectives in PD‐1 blockade cancer immunotherapy. Kenji Chamoto, Ryusuke Hatae, Tasuku Honjo. International Journal of Clinical Oncology, 2020 Jan 3, doi:10.1007/s10147-019-01588-7 (2020) 

641. Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy
Ryusuke Hatae, Kenji Chamoto, Young Hak Kim, Kazuhiro Sonomura, Kei Taneishi, Shuji Kawaguchi, Hironori Yoshida, Hiroaki Ozasa, Yuichi Sakamori, Maryam Akrami, Sidonia Fagarasan, Izuru Masuda, Yasushi Okuno, Fumihiko Matsuda, Toyohiro Hirai, and Tasuku Honjo. JCI Insight. 2020;5(2):e133501. doi:10.1172/jci.insight.133501 (2020) 

642. Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy
Alok Kumar, Kenji Chamoto, Partha S Chowdhury, Tasuku Honjo, Kumar et al. eLife 2020;9:e52330. doi:10.7554/eLife.52330 (2020) 

643. RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase. Yin, Z., Kobayashi, M., Hu, W., Higashi, K., Begum, N.A., Kurokawa, K., and Honjo, T. PNAS May 26, 2020 117 (21) 11624-11635 doi:10.1073/pnas.1921115117 (2020) 

644. SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination. Afzal Husain, Jiangliang Xu, Hodaka Fujii, Mikiyo Nakata, Maki Kobayashi, Ji-Yang Wang, Tasuku Honjo, & Nasim A Begum. The EMBO Journal e102931 2020, doi:10.15252/embj.2019102931 (2020) 

645. Circulation of gut-preactivated naïve CD8+ T cells enhances antitumor immunity in B cell-defective mice. Maryam Akrami, Rosemary Menzies, Kenji Chamoto, Michio Miyajima, Ryuji Suzuki, Hiroyuki Sato, Akiko Nishii, Michio Tomura, Sidonia Fagarasan, Tasuku Honjo. PNAS September 22, 2020 117 (38) 23674-23683, doi:10.1073/pnas.2010981117 (2020) 

646. Inactivation of the PD-1-Dependent Immunoregulation in Mice Exacerbates Contact Hypersensitivity
Resembling Immune-Related Adverse Events.Matin Dokht Ashoori, Kensuke Suzuki, Yosuke Tokumaru, Naoko Ikuta, Masaki Tajima, Tasuku Honjo and Akio Ohta. Front. Immunol., 27 January 2021, doi:10.3389/fimmu.2020.618711 (2021) 

Hayashi H, Chamoto K (Co-corresponding author), Hatae R, Kurosaki T, Togashi Y, Fukuoka K, Goto M, Chiba Y, Tomida S, Ota T, Haratani K, Takahama T, Tanizaki J, Yoshida T, Iwasa T, Tanaka K, Takeda M, Hirano T, Yoshida H, Ozasa H, Sakamori Y, Sakai K, Higuchi K, Uga H, Suminaka C, Hirai T, Nishio K, Nakagawa K, Honjo T. Soluble immune checkpoint factors reflect exhaustion of antitumor immunity and response to PD-1 blockade. (2024) J Clin Invest. 134(7):e168318. doi: 10.1172/JCI168318