CCII 京都大学大学院医学研究科附属 がん免疫総合研究センター

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  5. 杉浦 悠毅 特定准教授

杉浦悠毅 特定准教授
マルチオミクスプ・ラットフォーム

学歴

  • 2010: 東京工業大学院生命理工学研究科、博士課程卒業

職歴

  • 2011: JST さきがけ 専任研究員 (慢性炎症)
  • 2011: 慶應義塾大学 医学部 医化学教室、特任講師　
  • 2014: JST さきがけ 専任研究員 (疾患代謝)
  • 2015: 慶應義塾大学 医学部 医化学教室、専任講師
  • 2022~: 京都大学 大学院医学研究科附属　がん免疫総合研究センター マルチオミクスプ・ラットフォーム、特定准教授

研究内容

受賞歴

主な論文

Sone, M., Mitsuhashi, N., Sugiura, Y. et al. Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator. Cell Death Dis 15, 685 (2024). DOI: https://doi.org/10.1038/s41419-024-07059-w

Shintaro Watanuki, Hiroshi Kobayashi, Yuki Sugiura, Masamichi Yamamoto, Daiki Karigane, Kohei Shiroshita, Yuriko Sorimachi, Takayuki Morikawa, Shinya Fujita, Kotaro Shide, Miho Haraguchi, Shinpei Tamaki, Takumi Mikawa, Hiroshi Kondoh, Hiroyasu Nakano, Kenta Sumiyama, Go Nagamatsu, Nobuhito Goda, Shinichiri Okamoto, Ayako Nakamura-Ishizu, Kazuya Shimoda, Makoto Suematsu, Toshio Suda, Keiyo Takubo, SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production. Cell Stem Cell, Volume 31, Issue 8, 2024, Pages 1145-1161.e15, DOI: https://doi.org/10.1016/j.stem.2024.04.023.

Yamashita, Si., Sugiura, Y., Matsuoka, Y. et al. Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species.Cell Death Differ 31, 651–661 (2024). DOI: https://doi.org/10.1038/s41418-024-01280-y

Maeda, R., Seki, N., Uwamino, Y. et al. Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19. Nat Commun 14, 8469 (2023). DOI: https://doi.org/10.1038/s41467-023-44266-z

Nomura, M., Ohuchi, M., Sakamoto, Y. et al. Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma. Nat Commun 14, 8095 (2023). DOI: https://doi.org/10.1038/s41467-023-43630-3

Kazuya Nishio, Tomoyuki Kawarasaki, Yuki Sugiura, Shunsuke Matsumoto, Ayano Konoshima, Yuki Takano, Mayuko Hayashi, Fumihiko Okumura, Takumi Kamura, Tsunehiro Mizushima, Kunio Nakatsukasa. Defective import of mitochondrial metabolic elicits ectopic metabolic stress. Science advances, 9(15) eadf1956, Apr 14, 2023. DOI: https://doi.org/10.1126/sciadv.adf1956  

Hirona Kugo, Yuki Sugiura, Rena Fujishima, Shintou Jo, Hirotaka Mishima, Erina Sugamoto, Hiroki Tanaka, Satoshi Yamaguchi, Yoshihiko Ikeda, Ken-Ichi Hirano, Tatsuya Moriyama, Nobuhiro Zaima. Tricaprin can prevent the development of AAA by attenuating aortic degeneration. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 160 114299-114299, Apr, 2023. DOI: https://doi.org/10.1016/j.biopha.2023.114299  

Nourin Jahan, Hiroyuki Ohsaki, Kiyoko Kaneko, Asadur Rahman, Takeshi Nishiyama, Makoto Koizumi, Shuichiro Yamanaka, Kento Kitada, Yuki Sugiura, Kenji Matsui, Takashi Yokoo, Takayuki Hamano, Makoto Kuro-O, Takuya Itou, Miwa Suzuki, Keiichi Ueda, Akira Nishiyama. Possible contribution of phosphate to the pathogenesis of chronic kidney disease in dolphins. Scientific reports, 13(1) 5161-5161, Mar 29, 2023. DOI: https://doi.org/10.1038/s41598-023-32399-6  

Yu Nakagama, Katherine Candray, Natsuko Kaku, Yuko Komase, Maria-Virginia Rodriguez-Funes, Rhina Dominguez, Tomoya Tsuchida, Hiroyuki Kunishima, Etsuko Nagai, Eisuke Adachi, Dieudonné Mumba Ngoyi, Mari Yamasue, Kosaku Komiya, Kazufumi Hiramatsu, Naoto Uemura, Yuki Sugiura, Mayo Yasugi, Yuka Yamagishi, Hiroshige Mikamo, Satoshi Shiraishi, Takehiro Izumo, Sachie Nakagama, Chihiro Watanabe, Yuko Nitahara, Evariste Tshibangu-Kabamba, Hiroshi Kakeya, Yasutoshi Kido. Antibody Avidity Maturation Following Recovery From Infection or the Booster Vaccination Grants Breadth of SARS-CoV-2 Neutralizing Capacity. The Journal of infectious diseases, 227(6) 780-787, Mar 28, 2023. DOI: https://doi.org/10.1093/infdis/jiac492  

Shintaro Watanuki, Hiroshi Kobayashi, Yuki Sugiura, Masamichi Yamamoto, Daiki Karigane, Kohei Shiroshita, Yuriko Sorimachi, Shuhei Koide, Motohiko Oshima, Akira Nishiyama, Koichi Murakami, Miho Haraguchi, Shinpei Tamaki, Takehiro Yamamoto, Tomohiro Yabushita, Yosuke Tanaka, Hiroaki Honda, Shinichiro Okamoto, Nobuhito Goda, Tomohiko Tamura, Ayako Nakamura-Ishizu, Makoto Suematsu, Atsushi Iwama, Toshio Suda, Keiyo Takubo. Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis. bioRxiv, Mar 16, 2023. DOI: https://doi.org/10.1101/2023.03.16.532898 

Xiaoxiao Liu, Naru Sato, Tomohiro Yabushita, Jingmei Li, Yuhan Jia, Moe Tamura, Shuhei Asada, Takeshi Fujino, Tsuyoshi Fukushima, Taishi Yonezawa, Yosuke Tanaka, Tomofusa Fukuyama, Akiho Tsuchiya, Shiori Shikata, Hiroyuki Iwamura, Chieko Kinouchi, Kensuke Komatsu, Satoshi Yamasaki, Tatsuhiro Shibata, Atsuo T Sasaki, Janet Schibler, Mark Wunderlich, Eric O’Brien, Benjamin Mizukawa, James C Mulloy, Yuki Sugiura, Hitoshi Takizawa, Takuma Shibata, Kensuke Miyake, Toshio Kitamura, Susumu Goyama. IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia. EMBO molecular medicine, 15(1) e15631, Jan 11, 2023. DOI: https://doi.org/10.15252/emmm.202115631  

Kenji Morino, Kazufumi Kunimura, Yuki Sugiura, Yoshihiro Izumi, Keisuke Matsubara, Sayaka Akiyoshi, Rae Maeda, Kenichiro Hirotani, Daiji Sakata, Seiya Mizuno, Satoru Takahashi, Takeshi Bamba, Takehito Uruno, Yoshinori Fukui. Cholesterol sulfate limits neutrophil recruitment and gut inflammation during mucosal injury. Frontiers in immunology, 14 1131146-1131146, 2023. DOI: https://doi.org/10.3389/fimmu.2023.1131146  

Muna Al-Habsi, Kenji Chamoto, Ken Matsumoto, Norimichi Nomura, Baihao Zhang, Yuki Sugiura, Kazuhiro Sonomura, Aprilia Maharani, Yuka Nakajima, Yibo Wu, Yayoi Nomura, Rosemary Menzies, Masaki Tajima, Koji Kitaoka, Yasuharu Haku, Sara Delghandi, Keiko Yurimoto, Fumihiko Matsuda, So Iwata, Toshihiko Ogura, Sidonia Fagarasan, Tasuku Honjo. Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice. Science (New York, N.Y.), 378(6618) eabj3510, Oct 28, 2022. DOI: https://doi.org/10.1126/science.abj3510  

Shota Yamauchi, Yuki Sugiura, Junji Yamaguchi, Xiangyu Zhou, Takeru Odawara, Shunsuke Fukaya, Isao Naguro, Yasuo Uchiyama, Hidenori Ichijo. DNA damage response signaling to mitochondria drives senescence. bioRxiv, Sep 22, 2022. DOI: https://doi.org/10.1101/2022.09.22.509001  

Natsumi Seki, Tatsuki Kimizuka, Monica Gondo, Genki Yamaguchi, Yuki Sugiura, Masahiro Akiyama, Kyosuke Yakabe, Jun Uchiyama, Seiichiro Higashi, Takeshi Haneda, Makoto Suematsu, Koji Hase, Yun-Gi Kimi. D-Tryptophan suppresses enteric pathogen and pathobionts and prevents colitis by modulating microbial tryptophan metabolism. Science, 25(8) 104838-104838, Aug 19, 2022. DOI: https://doi.org/10.1016/j.isci.2022.104838  

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